GREMLIN Database
DUF1580 - Protein of unknown function (DUF1580)
PFAM: PF07618 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 57 (46)
Sequences: 2737 (2255)
Seq/√Len: 332.5
META: 0.988

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_A35_T3.4611.00
35_T42_R3.0821.00
34_E51_R2.7391.00
34_E48_A2.1471.00
50_Q54_E2.1101.00
37_R42_R1.9831.00
16_V20_W1.6751.00
46_R50_Q1.6321.00
20_W24_L1.6261.00
15_H18_T1.5871.00
47_E51_R1.5761.00
49_L53_I1.2761.00
45_S48_A1.2681.00
48_A51_R1.2221.00
20_W23_A1.1951.00
44_T48_A1.1481.00
38_V53_I1.1361.00
45_S51_R1.1131.00
26_G52_F1.0611.00
17_S20_W1.0251.00
36_V45_S1.0251.00
32_R35_T1.0241.00
23_A42_R1.0211.00
34_E52_F1.0031.00
15_H20_W0.9971.00
38_V43_Y0.9881.00
9_R49_L0.9411.00
36_V43_Y0.8851.00
14_P22_W0.8831.00
36_V53_I0.8811.00
22_W49_L0.8461.00
26_G30_G0.8361.00
18_T22_W0.8331.00
36_V48_A0.8291.00
27_V30_G0.8061.00
12_R41_R0.7921.00
14_P19_L0.7841.00
9_R12_R0.7761.00
43_Y53_I0.7520.99
24_L42_R0.7420.99
31_V55_A0.7310.99
28_R37_R0.7300.99
17_S21_R0.7210.99
31_V53_I0.7060.99
27_V52_F0.6700.99
47_E50_Q0.6520.99
20_W42_R0.6510.99
44_T49_L0.6470.98
27_V31_V0.6390.98
34_E45_S0.6380.98
19_L23_A0.6080.98
26_G32_R0.6080.98
37_R40_G0.6030.98
18_T39_G0.5940.97
9_R14_P0.5920.97
22_W27_V0.5740.97
27_V40_G0.5610.96
34_E44_T0.5570.96
13_R21_R0.5570.96
31_V52_F0.5570.96
50_Q53_I0.5490.96
10_P43_Y0.5360.95
10_P14_P0.5280.95
25_R33_L0.5270.95
11_G14_P0.5260.95
24_L37_R0.5220.95
28_R40_G0.5090.94
23_A37_R0.5020.93
36_V44_T0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y6uA 1 0.8772 94.7 0.691 Contact Map
4j2nA 4 0.8421 92.6 0.715 Contact Map
1z4hA 1 0.8596 91.4 0.725 Contact Map
1j9iA 2 0.8421 90.4 0.731 Contact Map
2og0A 1 0.8421 87.6 0.745 Contact Map
1pm6A 1 0.8947 79.4 0.769 Contact Map
2kfsA 1 0.8596 74.8 0.778 Contact Map
2ao9A 7 0.8947 55.3 0.805 Contact Map
2elhA 1 0.8421 46.8 0.815 Contact Map
2jmlA 1 0.8772 46.5 0.815 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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