GREMLIN Database
DUF1576 - Protein of unknown function (DUF1576)
PFAM: PF07613 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 175 (172)
Sequences: 2429 (1727)
Seq/√Len: 131.7
META: 0.847

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_A162_A5.0351.00
38_L77_I3.8041.00
42_S64_V3.4851.00
38_L68_S3.2521.00
90_L137_F3.1711.00
8_L12_L3.0011.00
86_L133_I2.9961.00
39_G65_V2.7991.00
80_I105_G2.5611.00
4_I33_I2.4321.00
23_I28_I2.4061.00
84_V102_A2.3511.00
60_G104_F2.2651.00
36_G40_L2.1981.00
20_T25_L2.1651.00
51_G99_I2.1491.00
35_M65_V2.1441.00
105_G139_H2.1231.00
9_K13_K2.0811.00
14_S26_G2.0691.00
11_I26_G2.0071.00
75_L116_A1.9881.00
82_L133_I1.9551.00
31_T69_A1.8751.00
72_K106_T1.7321.00
11_I30_A1.7191.00
22_Y73_N1.7181.00
139_H158_N1.6931.00
10_K26_G1.6811.00
38_L74_L1.6161.00
8_L33_I1.5921.00
42_S103_L1.5901.00
35_M69_A1.5631.00
87_Y137_F1.5331.00
93_E98_Y1.5281.00
146_V161_A1.5251.00
16_G22_Y1.4961.00
143_A161_A1.4521.00
142_L161_A1.4481.00
19_I70_F1.4471.00
42_S81_M1.4101.00
68_S77_I1.3991.00
130_L134_L1.3661.00
145_H148_K1.3501.00
41_I74_L1.3451.00
14_S20_T1.3351.00
44_L48_L1.3321.00
4_I30_A1.3311.00
12_L74_L1.3271.00
38_L64_V1.3191.00
81_M102_A1.3061.00
31_T35_M1.3041.00
56_P100_L1.2931.00
112_V132_G1.2711.00
93_E97_G1.2701.00
46_V61_I1.2671.00
131_A173_L1.2631.00
59_A104_F1.2561.00
98_Y140_P1.2551.00
131_A134_L1.2401.00
116_A128_G1.2361.00
14_S25_L1.2141.00
84_V105_G1.2091.00
7_G30_A1.2020.99
45_L49_L1.1930.99
6_K10_K1.1840.99
8_L37_L1.1660.99
111_I135_A1.1630.99
145_H149_L1.1580.99
46_V99_I1.1360.99
63_T107_A1.1260.99
102_A105_G1.1120.99
23_I31_T1.1100.99
6_K9_K1.0910.99
88_A98_Y1.0900.99
5_L9_K1.0890.99
72_K103_L1.0860.99
101_A139_H1.0720.99
16_G113_G1.0650.99
44_L47_L1.0480.99
4_I7_G1.0420.99
92_K95_F1.0170.98
49_L99_I1.0120.98
10_K13_K1.0080.98
148_K151_G0.9930.98
146_V164_L0.9780.98
40_L44_L0.9640.98
8_L30_A0.9600.97
18_L70_F0.9540.97
142_L146_V0.9530.97
59_A63_T0.9500.97
164_L167_T0.9460.97
67_F72_K0.9310.97
124_G128_G0.9290.97
46_V57_T0.9230.97
115_F174_R0.9080.96
65_V103_L0.9070.96
76_N113_G0.8990.96
57_T100_L0.8970.96
65_V93_E0.8900.96
11_I14_S0.8870.96
82_L86_L0.8860.96
17_R114_E0.8840.96
26_G30_A0.8720.96
121_L124_G0.8680.95
7_G29_G0.8640.95
27_G30_A0.8630.95
28_I32_L0.8610.95
146_V149_L0.8590.95
20_T70_F0.8550.95
68_S72_K0.8540.95
7_G10_K0.8520.95
41_I78_L0.8490.95
120_G124_G0.8480.95
45_L102_A0.8470.95
114_E167_T0.8400.95
59_A62_F0.8380.94
45_L95_F0.8360.94
79_P129_I0.8250.94
87_Y141_P0.8210.94
73_N113_G0.8190.94
145_H153_Y0.8160.94
108_L162_A0.8110.93
52_D96_P0.8080.93
46_V51_G0.8030.93
50_G94_P0.8010.93
73_N76_N0.7910.93
84_V150_H0.7910.93
7_G27_G0.7830.92
108_L111_I0.7760.92
100_L113_G0.7720.92
111_I166_A0.7680.91
93_E102_A0.7650.91
138_L165_V0.7580.91
120_G123_L0.7570.91
62_F65_V0.7450.90
56_P59_A0.7360.90
33_I37_L0.7350.90
145_H151_G0.7350.90
56_P62_F0.7310.89
41_I77_I0.7260.89
116_A123_L0.7260.89
159_G163_G0.7220.89
80_I106_T0.7200.89
12_L73_N0.7180.89
91_K141_P0.7110.88
60_G103_L0.7060.88
145_H150_H0.6990.87
167_T171_P0.6960.87
30_A33_I0.6960.87
8_L74_L0.6900.86
124_G127_L0.6880.86
23_I32_L0.6870.86
49_L102_A0.6790.86
144_A148_K0.6760.85
78_L81_M0.6730.85
39_G61_I0.6670.85
48_L134_L0.6670.85
64_V72_K0.6660.85
79_P112_V0.6650.84
45_L98_Y0.6650.84
85_Y102_A0.6600.84
45_L81_M0.6590.84
115_F131_A0.6590.84
77_I109_A0.6530.83
143_A158_N0.6520.83
62_F104_F0.6520.83
70_F114_E0.6480.83
119_L123_L0.6480.83
85_Y93_E0.6460.83
119_L126_P0.6410.82
63_T149_L0.6330.81
169_L173_L0.6280.81
170_V174_R0.6250.81
123_L126_P0.6240.80
165_V168_F0.6240.80
144_A153_Y0.6240.80
51_G100_L0.6200.80
37_L74_L0.6190.80
111_I169_L0.6190.80
36_G148_K0.6170.80
116_A125_I0.6130.79
9_K12_L0.6130.79
158_N161_A0.6100.79
116_A120_G0.6090.79
63_T104_F0.6060.79
42_S105_G0.6050.78
41_I81_M0.6050.78
114_E162_A0.6040.78
95_F98_Y0.6020.78
113_G132_G0.6000.78
20_T26_G0.5990.78
146_V150_H0.5980.78
78_L82_L0.5950.77
82_L85_Y0.5940.77
125_I128_G0.5930.77
23_I69_A0.5910.77
5_L8_L0.5900.77
42_S61_I0.5860.76
67_F70_F0.5860.76
119_L124_G0.5840.76
46_V103_L0.5810.76
155_L162_A0.5800.75
7_G26_G0.5690.74
43_L53_L0.5680.74
85_Y88_A0.5670.74
102_A140_P0.5650.74
38_L72_K0.5650.74
49_L100_L0.5620.73
116_A124_G0.5580.73
98_Y144_A0.5550.72
51_G56_P0.5540.72
147_G151_G0.5530.72
88_A102_A0.5510.72
60_G84_V0.5500.72
38_L42_S0.5480.71
6_K86_L0.5460.71
95_F99_I0.5460.71
43_L61_I0.5440.71
7_G94_P0.5420.71
167_T174_R0.5380.70
65_V68_S0.5380.70
89_L92_K0.5380.70
79_P132_G0.5380.70
18_L25_L0.5370.70
135_A169_L0.5360.70
72_K77_I0.5330.69
160_F164_L0.5320.69
38_L103_L0.5320.69
85_Y129_I0.5310.69
85_Y89_L0.5310.69
87_Y140_P0.5310.69
11_I91_K0.5300.69
62_F107_A0.5300.69
123_L127_L0.5260.68
27_G32_L0.5260.68
66_G155_L0.5250.68
10_K25_L0.5250.68
13_K16_G0.5240.68
14_S22_Y0.5230.68
86_L174_R0.5220.68
111_I124_G0.5200.67
19_I24_A0.5190.67
5_L10_K0.5190.67
33_I146_V0.5180.67
120_G126_P0.5160.67
122_P127_L0.5160.67
119_L127_L0.5130.66
5_L130_L0.5100.66
112_V129_I0.5090.66
9_K24_A0.5080.66
118_G121_L0.5060.65
118_G149_L0.5030.65
86_L137_F0.5020.65
105_G150_H0.5010.65
83_G132_G0.5010.65
115_F128_G0.5000.64
91_K98_Y0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m5bA 1 0.8114 19.2 0.948 Contact Map
2gfpA 2 0.8971 7.4 0.957 Contact Map
3o7qA 1 0.8914 7.2 0.957 Contact Map
4w252 1 0.3257 6.1 0.958 Contact Map
2nwlA 3 0.3143 4.9 0.96 Contact Map
2ww9B 1 0.3143 3.4 0.963 Contact Map
2cfqA 1 0.8914 3.2 0.964 Contact Map
3wdoA 1 0.8857 2.3 0.966 Contact Map
2kluA 1 0.1943 2.1 0.967 Contact Map
4e17B 1 0.1371 2 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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