GREMLIN Database
UnbV_ASPIC - ASPIC and UnbV
PFAM: PF07593 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (67)
Sequences: 84743 (50746)
Seq/√Len: 6199.6
META: 0.977

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_S57_T2.7551.00
9_T45_S2.6361.00
7_T49_R2.3371.00
9_T14_T2.1671.00
47_E55_V2.1331.00
7_T14_T2.1201.00
7_T47_E2.1011.00
49_R55_V1.9801.00
47_E57_T1.8831.00
42_K60_N1.6901.00
9_T47_E1.6641.00
6_V33_L1.6621.00
17_R35_F1.6591.00
7_T16_V1.6581.00
5_R18_E1.6001.00
45_S59_T1.5961.00
10_A15_Q1.4911.00
5_R16_V1.4301.00
17_R33_L1.3961.00
19_V33_L1.3961.00
50_W56_Q1.3261.00
8_V35_F1.2951.00
32_R66_I1.2791.00
11_G40_A1.2621.00
13_G40_A1.2601.00
11_G44_D1.2481.00
23_S29_S1.1991.00
62_A65_Q1.1841.00
61_V67_L1.1681.00
9_T44_D1.1181.00
5_R49_R1.1091.00
12_G40_A1.1051.00
46_V61_V1.0961.00
10_A40_A1.0931.00
37_L63_A1.0521.00
58_L61_V1.0521.00
4_A48_V1.0371.00
20_R23_S1.0051.00
28_Q31_L0.9941.00
30_D34_H0.9671.00
37_L43_V0.9481.00
42_K62_A0.9431.00
10_A13_G0.9331.00
22_G28_Q0.9241.00
23_S26_L0.8961.00
43_V63_A0.8721.00
8_V37_L0.8641.00
21_S28_Q0.8411.00
34_H66_I0.8371.00
19_V31_L0.8201.00
23_S30_D0.8181.00
40_A44_D0.8101.00
2_I21_S0.8091.00
8_V43_V0.7641.00
8_V46_V0.7441.00
15_Q35_F0.7441.00
2_I31_L0.7371.00
23_S27_S0.7301.00
19_V30_D0.7261.00
20_R26_L0.7111.00
22_G29_S0.7101.00
21_S31_L0.7011.00
17_R20_R0.6951.00
19_V32_R0.6931.00
4_A51_P0.6881.00
21_S29_S0.6671.00
41_T62_A0.6461.00
25_Y28_Q0.6381.00
1_A4_A0.6301.00
6_V46_V0.6271.00
2_I22_G0.6211.00
2_I19_V0.6201.00
17_R22_G0.6061.00
48_V58_L0.6031.00
20_R29_S0.6031.00
23_S28_Q0.6001.00
19_V22_G0.5891.00
11_G42_K0.5811.00
63_A67_L0.5731.00
2_I20_R0.5731.00
1_A19_V0.5691.00
31_L34_H0.5681.00
19_V24_G0.5671.00
46_V67_L0.5581.00
24_G30_D0.5571.00
24_G29_S0.5471.00
1_A56_Q0.5441.00
6_V48_V0.5411.00
10_A44_D0.5401.00
26_L30_D0.5381.00
4_A19_V0.5331.00
44_D59_T0.5211.00
62_A67_L0.5181.00
17_R34_H0.5171.00
61_V65_Q0.5141.00
18_E23_S0.5131.00
24_G36_G0.5091.00
58_L67_L0.5061.00
6_V35_F0.5031.00
52_S55_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qqrA 1 0.9706 36.6 0.817 Contact Map
4a7kA 2 0.9559 22.4 0.835 Contact Map
2xdpA 2 0.9706 19.3 0.84 Contact Map
3ujzA 2 0.4118 16.1 0.846 Contact Map
2mamA 1 0.9412 12.6 0.853 Contact Map
3dmqA 1 0.7206 11.1 0.856 Contact Map
2mcaA 1 0.6765 9.6 0.861 Contact Map
1nc7A 3 0.9265 8.7 0.863 Contact Map
2e5pA 1 0.5588 8.2 0.864 Contact Map
2iiaA 3 0.7941 6.4 0.871 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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