GREMLIN Database
PSD1 - Protein of unknown function (DUF1553)
PFAM: PF07587 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 244 (242)
Sequences: 45286 (33498)
Seq/√Len: 2153.3
META: 0.961

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_H72_H3.7331.00
64_S70_A3.4031.00
221_E237_L3.0541.00
60_E70_A3.0131.00
60_E64_S2.9121.00
67_S70_A2.8781.00
36_E46_E2.7591.00
110_E113_V2.7581.00
59_V63_E2.7451.00
221_E231_P2.6941.00
60_E74_L2.6331.00
213_L223_A2.6271.00
21_I68_L2.5861.00
212_R226_L2.5111.00
32_R36_E2.4921.00
79_A83_Q2.3641.00
27_Q38_P2.1891.00
91_A102_A2.1821.00
60_E63_E2.1631.00
3_L7_R2.1461.00
22_V71_L2.1231.00
225_R231_P2.1001.00
73_R77_T2.0951.00
124_L205_A2.0791.00
88_T91_A2.0571.00
64_S74_L2.0481.00
87_A92_L1.9501.00
124_L208_A1.9221.00
29_H76_V1.9211.00
118_A202_V1.8841.00
222_R226_L1.8461.00
238_A242_A1.8221.00
221_E232_P1.8201.00
12_P62_V1.7841.00
25_V71_L1.7681.00
74_L77_T1.7051.00
146_S150_D1.7021.00
70_A74_L1.6771.00
209_L227_A1.6641.00
90_E93_E1.6371.00
56_W74_L1.6311.00
59_V62_V1.6291.00
230_R236_E1.6221.00
218_E221_E1.5901.00
216_E222_R1.5781.00
25_V72_H1.5391.00
90_E94_K1.5381.00
234_A238_A1.5281.00
61_F68_L1.5071.00
208_A211_E1.4981.00
224_Y232_P1.4951.00
220_I241_L1.4631.00
174_A177_R1.4471.00
32_R99_R1.4431.00
35_V41_F1.4421.00
56_W60_E1.4371.00
235_E238_A1.4251.00
109_L117_A1.4041.00
64_S67_S1.4021.00
117_A121_V1.3831.00
201_F205_A1.3801.00
124_L152_Y1.3691.00
4_A7_R1.3681.00
109_L113_V1.3601.00
22_V61_F1.3531.00
221_E225_R1.3401.00
18_A62_V1.3351.00
112_E184_R1.3351.00
237_L241_L1.3201.00
89_P93_E1.3171.00
126_D149_E1.3141.00
71_L75_I1.3101.00
49_S99_R1.2841.00
68_L72_H1.2831.00
29_H75_I1.2701.00
200_P204_E1.2681.00
222_R225_R1.2621.00
62_V66_W1.2581.00
213_L222_R1.2451.00
18_A66_W1.2391.00
12_P63_E1.2321.00
115_R155_S1.2261.00
211_E215_K1.2241.00
204_E207_R1.2201.00
72_H76_V1.2171.00
89_P92_L1.2111.00
140_P143_Y1.2081.00
232_P237_L1.1991.00
11_S14_N1.1951.00
128_K150_D1.1931.00
175_P184_R1.1911.00
80_T101_L1.1901.00
209_L223_A1.1881.00
98_N105_P1.1811.00
27_Q33_G1.1691.00
19_R55_D1.1611.00
39_D182_V1.1581.00
118_A205_A1.1561.00
25_V29_H1.1531.00
171_T195_F1.1511.00
207_R211_E1.1501.00
168_F195_F1.1391.00
46_E99_R1.1371.00
224_Y240_L1.1321.00
25_V68_L1.1241.00
135_K159_F1.1231.00
21_I25_V1.1211.00
205_A208_A1.1181.00
14_N17_T1.1141.00
36_E97_D1.1131.00
77_T82_R1.1061.00
217_A222_R1.1041.00
80_T83_Q1.0981.00
21_I61_F1.0911.00
220_I240_L1.0821.00
7_R10_T1.0811.00
141_R144_V1.0791.00
104_G107_R1.0691.00
9_L17_T1.0601.00
239_A242_A1.0561.00
206_A209_L1.0471.00
60_E71_L1.0431.00
107_R186_R1.0271.00
30_F75_I1.0111.00
120_A127_P1.0111.00
135_K146_S1.0071.00
121_V227_A0.9951.00
214_L219_R0.9951.00
128_K149_E0.9861.00
140_P144_V0.9721.00
5_L9_L0.9721.00
88_T102_A0.9681.00
166_P169_L0.9561.00
155_S158_T0.9481.00
40_D44_Q0.9471.00
27_Q183_R0.9471.00
76_V81_Y0.9441.00
29_H81_Y0.9431.00
95_D98_N0.9371.00
55_D58_A0.9371.00
238_A241_L0.9361.00
71_L74_L0.9321.00
219_R222_R0.9281.00
235_E239_A0.9191.00
20_V41_F0.9141.00
199_D202_V0.9141.00
234_A237_L0.9131.00
87_A102_A0.9121.00
101_L105_P0.9111.00
134_V158_T0.9081.00
137_Y151_L0.9071.00
32_R183_R0.9011.00
212_R216_E0.8961.00
10_T62_V0.8921.00
56_W59_V0.8851.00
39_D180_C0.8831.00
61_F71_L0.8731.00
214_L217_A0.8701.00
135_K138_Q0.8701.00
117_A120_A0.8671.00
58_A62_V0.8671.00
129_M156_L0.8641.00
146_S149_E0.8581.00
130_G153_R0.8551.00
79_A82_R0.8501.00
223_A226_L0.8421.00
173_D185_S0.8421.00
203_V207_R0.8401.00
36_E99_R0.8351.00
49_S101_L0.8271.00
25_V75_I0.8251.00
17_T66_W0.8251.00
64_S71_L0.8241.00
204_E208_A0.8211.00
176_D179_V0.8141.00
145_Q149_E0.8121.00
115_R119_L0.8111.00
224_Y228_L0.8101.00
91_A100_L0.8071.00
55_D59_V0.8041.00
39_D183_R0.8021.00
30_F101_L0.8011.00
129_M133_S0.7991.00
225_R229_S0.7991.00
160_W177_R0.7991.00
129_M153_R0.7981.00
160_W174_A0.7891.00
43_R47_P0.7861.00
169_L174_A0.7831.00
120_A125_L0.7801.00
32_R97_D0.7791.00
209_L213_L0.7791.00
37_T46_E0.7721.00
18_A58_A0.7671.00
138_Q164_V0.7661.00
209_L226_L0.7641.00
165_P170_E0.7641.00
70_A77_T0.7611.00
145_Q148_G0.7581.00
163_T178_E0.7581.00
129_M132_P0.7541.00
206_A210_A0.7541.00
136_P158_T0.7541.00
233_T237_L0.7531.00
135_K144_V0.7511.00
25_V28_H0.7481.00
65_G70_A0.7471.00
94_K102_A0.7471.00
83_Q91_A0.7401.00
231_P234_A0.7381.00
145_Q151_L0.7331.00
6_A10_T0.7291.00
128_K131_G0.7251.00
87_A103_R0.7241.00
121_V209_L0.7221.00
228_L231_P0.7191.00
10_T17_T0.7191.00
91_A94_K0.7161.00
147_T150_D0.7161.00
18_A21_I0.7151.00
154_R157_Y0.7141.00
224_Y236_E0.7101.00
231_P237_L0.7101.00
119_L125_L0.7061.00
72_H75_I0.7041.00
122_S205_A0.6981.00
111_A174_A0.6961.00
135_K139_P0.6961.00
133_S136_P0.6961.00
30_F80_T0.6961.00
155_S169_L0.6941.00
6_A9_L0.6931.00
237_L240_L0.6911.00
146_S151_L0.6901.00
211_E214_L0.6881.00
75_I78_S0.6791.00
51_P55_D0.6781.00
168_F171_T0.6781.00
172_F192_Q0.6761.00
220_I224_Y0.6751.00
168_F202_V0.6741.00
85_S104_G0.6731.00
161_K164_V0.6721.00
61_F65_G0.6711.00
25_V61_F0.6661.00
121_V226_L0.6661.00
70_A73_R0.6651.00
144_V147_T0.6631.00
27_Q32_R0.6571.00
145_Q150_D0.6571.00
50_H53_L0.6551.00
131_G153_R0.6541.00
122_S208_A0.6541.00
16_L20_V0.6521.00
22_V58_A0.6511.00
208_A212_R0.6511.00
10_T14_N0.6511.00
28_H110_E0.6461.00
113_V117_A0.6371.00
87_A91_A0.6331.00
21_I29_H0.6321.00
218_E222_R0.6311.00
158_T169_L0.6301.00
15_P19_R0.6291.00
126_D129_M0.6281.00
233_T236_E0.6281.00
136_P139_P0.6261.00
213_L219_R0.6211.00
33_G39_D0.6161.00
151_L158_T0.6151.00
137_Y145_Q0.6121.00
166_P201_F0.6121.00
161_K177_R0.6121.00
220_I237_L0.6101.00
48_P51_P0.6091.00
165_P174_A0.6081.00
107_R110_E0.6081.00
170_E176_D0.6041.00
9_L14_N0.6041.00
209_L212_R0.6041.00
28_H113_V0.6031.00
220_I232_P0.6031.00
114_I172_F0.6011.00
199_D203_V0.6001.00
62_V65_G0.5971.00
158_T166_P0.5961.00
45_G49_S0.5951.00
175_P181_T0.5921.00
213_L217_A0.5891.00
49_S52_E0.5881.00
152_Y205_A0.5871.00
213_L226_L0.5841.00
215_K218_E0.5821.00
196_L202_V0.5791.00
36_E183_R0.5791.00
111_A169_L0.5781.00
119_L126_D0.5781.00
17_T21_I0.5751.00
174_A178_E0.5741.00
112_E175_P0.5681.00
37_T45_G0.5671.00
164_V167_P0.5671.00
134_V137_Y0.5671.00
133_S159_F0.5671.00
15_P18_A0.5671.00
114_I117_A0.5671.00
33_G36_E0.5651.00
195_F199_D0.5611.00
212_R222_R0.5601.00
32_R105_P0.5581.00
153_R157_Y0.5561.00
110_E114_I0.5541.00
35_V46_E0.5521.00
167_P170_E0.5521.00
148_G151_L0.5521.00
239_A243_F0.5501.00
50_H101_L0.5481.00
38_P182_V0.5481.00
141_R164_V0.5471.00
170_E174_A0.5461.00
88_T92_L0.5431.00
46_E49_S0.5431.00
194_L198_N0.5421.00
134_V139_P0.5421.00
221_E234_A0.5421.00
160_W165_P0.5411.00
21_I24_R0.5411.00
128_K132_P0.5391.00
12_P65_G0.5391.00
210_A213_L0.5391.00
95_D103_R0.5381.00
160_W163_T0.5381.00
139_P143_Y0.5371.00
88_T94_K0.5351.00
28_H72_H0.5341.00
147_T151_L0.5341.00
50_H100_L0.5331.00
81_Y104_G0.5331.00
7_R11_S0.5281.00
126_D153_R0.5281.00
148_G152_Y0.5281.00
134_V151_L0.5271.00
52_E55_D0.5271.00
53_L56_W0.5241.00
14_N18_A0.5241.00
152_Y208_A0.5241.00
44_Q47_P0.5231.00
135_K145_Q0.5211.00
126_D150_D0.5211.00
36_E101_L0.5191.00
27_Q36_E0.5171.00
205_A209_L0.5161.00
118_A122_S0.5151.00
141_R161_K0.5141.00
60_E65_G0.5131.00
101_L104_G0.5121.00
114_I196_L0.5101.00
153_R158_T0.5081.00
76_V82_R0.5061.00
163_T166_P0.5051.00
152_Y204_E0.5011.00
195_F201_F0.5001.00
121_V228_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zc2A 1 0.1107 18.9 0.956 Contact Map
1h3lA 1 0.2664 12 0.96 Contact Map
2ysrA 1 0.2377 11.2 0.961 Contact Map
2maoA 1 0.3033 10.2 0.961 Contact Map
1or7A 2 0.3115 8.9 0.962 Contact Map
4cxfA 1 0.291 8.3 0.963 Contact Map
4qb3A 1 0.4303 7.7 0.963 Contact Map
1ufzA 1 0.2213 6.9 0.964 Contact Map
1o7xA 2 0.2664 6.7 0.964 Contact Map
2khvA 1 0.209 6.5 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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