GREMLIN Database
HXXSHH - Protein of unknown function (DUF1552)
PFAM: PF07586 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 304 (300)
Sequences: 20672 (13242)
Seq/√Len: 764.5
META: 0.967

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_K36_E3.4721.00
242_L254_A3.3891.00
191_D195_T3.2461.00
2_F90_A3.0231.00
36_E39_R3.0041.00
84_I92_Q2.9501.00
68_T85_S2.8471.00
105_L139_V2.8091.00
230_D233_E2.7681.00
249_D252_R2.6791.00
179_Q187_R2.6761.00
175_A194_L2.6491.00
21_G27_E2.6401.00
236_R302_Q2.4821.00
297_R301_E2.3771.00
195_T199_E2.3161.00
172_L176_K2.3161.00
3_G246_F2.2861.00
133_E138_A2.1811.00
176_K179_Q2.1561.00
15_R293_A2.1361.00
33_K297_R2.0781.00
179_Q191_D2.0711.00
285_D288_K2.0251.00
213_T216_P2.0071.00
184_A187_R1.9991.00
166_S198_R1.9971.00
133_E142_R1.9861.00
286_P290_A1.9811.00
29_S32_L1.9681.00
274_D291_K1.9491.00
198_R201_E1.9311.00
290_A294_K1.8881.00
32_L44_V1.8551.00
235_V258_L1.8391.00
21_G25_D1.8261.00
139_V241_L1.8131.00
124_R128_T1.7871.00
106_G132_P1.7771.00
38_F42_L1.7661.00
184_A188_A1.7521.00
90_A253_V1.7321.00
12_I15_R1.7231.00
158_A162_R1.7211.00
92_Q125_S1.7121.00
206_R209_A1.7011.00
232_E269_E1.6881.00
280_S292_L1.6731.00
15_R30_P1.6661.00
215_K218_P1.6611.00
287_E290_A1.6151.00
214_P217_L1.6021.00
84_I89_V1.5891.00
38_F41_D1.5851.00
153_T156_A1.5801.00
125_S128_T1.5761.00
104_E130_L1.5731.00
107_V235_V1.5681.00
246_F254_A1.5501.00
17_T46_S1.5321.00
137_R141_E1.5321.00
12_I289_I1.5161.00
30_P33_K1.5151.00
174_D177_R1.5061.00
89_V93_K1.4981.00
19_K29_S1.4941.00
19_K27_E1.4891.00
220_A223_P1.4881.00
93_K96_Q1.4831.00
177_R180_R1.4771.00
292_L296_N1.4691.00
23_G26_F1.4601.00
4_F86_I1.4521.00
239_F258_L1.4491.00
182_L190_L1.4471.00
92_Q101_P1.4361.00
166_S201_E1.4251.00
13_P17_T1.4211.00
5_V239_F1.4121.00
202_R206_R1.4081.00
51_P54_E1.4051.00
100_F250_L1.4001.00
28_L42_L1.3961.00
216_P219_D1.3951.00
24_A40_D1.3901.00
135_N138_A1.3881.00
7_V11_V1.3641.00
185_A188_A1.3401.00
233_E236_R1.3001.00
52_N71_H1.2931.00
232_E301_E1.2901.00
45_L48_L1.2891.00
122_S130_L1.2841.00
200_I244_L1.2801.00
86_I90_A1.2801.00
293_A297_R1.2801.00
294_K297_R1.2751.00
84_I126_P1.2681.00
88_Q102_S1.2671.00
159_A163_R1.2451.00
199_E202_R1.2391.00
158_A161_L1.2361.00
103_L143_L1.2321.00
269_E298_Y1.2301.00
210_W213_T1.2271.00
30_P297_R1.2151.00
92_Q124_R1.2051.00
243_A247_Q1.1991.00
34_P297_R1.1901.00
173_E176_K1.1841.00
223_P226_I1.1811.00
28_L39_R1.1701.00
90_A94_I1.1651.00
34_P37_P1.1401.00
166_S169_D1.1391.00
133_E139_V1.1381.00
205_Q208_E1.1381.00
25_D39_R1.1341.00
81_R126_P1.1311.00
139_V238_M1.1281.00
75_T79_D1.1281.00
73_K79_D1.1271.00
239_F243_A1.1241.00
212_D215_K1.1241.00
35_L42_L1.1211.00
26_F39_R1.1131.00
50_H65_A1.1111.00
291_K294_K1.1031.00
155_A159_A1.1011.00
188_A192_E1.0871.00
160_R163_R1.0871.00
287_E291_K1.0841.00
27_E36_E1.0831.00
211_A214_P1.0821.00
195_T202_R1.0821.00
203_R240_D1.0761.00
232_E236_R1.0761.00
27_E33_K1.0751.00
28_L36_E1.0681.00
138_A141_E1.0651.00
40_D43_T1.0621.00
240_D243_A1.0461.00
155_A158_A1.0421.00
221_P224_P1.0391.00
154_P158_A1.0361.00
199_E203_R1.0291.00
5_V303_F1.0281.00
30_P290_A1.0241.00
3_G254_A1.0201.00
176_K180_R1.0111.00
90_A93_K1.0071.00
31_I296_N1.0021.00
3_G242_L0.9981.00
275_G278_P0.9961.00
297_R300_V0.9861.00
156_A159_A0.9851.00
205_Q209_A0.9761.00
22_E25_D0.9751.00
279_L291_K0.9741.00
213_T217_L0.9701.00
236_R240_D0.9691.00
175_A179_Q0.9681.00
94_I253_V0.9641.00
179_Q194_L0.9641.00
242_L256_F0.9641.00
214_P218_P0.9631.00
26_F42_L0.9591.00
276_H280_S0.9571.00
105_L242_L0.9551.00
95_G98_T0.9521.00
57_G60_A0.9521.00
211_A215_K0.9461.00
21_G29_S0.9451.00
107_V238_M0.9441.00
179_Q195_T0.9421.00
34_P301_E0.9391.00
274_D278_P0.9361.00
213_T218_P0.9361.00
271_G294_K0.9331.00
124_R130_L0.9261.00
230_D269_E0.9251.00
120_T132_P0.9231.00
272_V279_L0.9221.00
70_A83_G0.9171.00
188_A191_D0.9161.00
296_N299_H0.9151.00
143_L250_L0.9151.00
211_A217_L0.9151.00
279_L295_I0.9141.00
223_P227_P0.9101.00
172_L175_A0.9081.00
91_A102_S0.9081.00
224_P227_P0.9071.00
103_L254_A0.9071.00
267_Y299_H0.9061.00
234_H238_M0.9041.00
290_A293_A0.9041.00
30_P293_A0.8921.00
222_A226_I0.8921.00
170_S174_D0.8901.00
283_G288_K0.8881.00
264_N278_P0.8851.00
31_I34_P0.8841.00
282_H288_K0.8841.00
104_E255_T0.8711.00
162_R165_R0.8661.00
217_L220_A0.8651.00
4_F67_L0.8651.00
264_N275_G0.8611.00
100_F105_L0.8591.00
4_F66_F0.8501.00
157_R161_L0.8461.00
58_G61_R0.8401.00
31_I293_A0.8401.00
31_I297_R0.8381.00
35_L300_V0.8361.00
298_Y302_Q0.8341.00
221_P227_P0.8291.00
274_D279_L0.8291.00
178_L190_L0.8271.00
104_E142_R0.8271.00
74_K77_G0.8231.00
27_E39_R0.8221.00
84_I125_S0.8211.00
273_P291_K0.8191.00
218_P221_P0.8181.00
50_H69_G0.8161.00
239_F256_F0.8141.00
122_S255_T0.8141.00
22_E26_F0.8111.00
245_A251_T0.8071.00
209_A213_T0.8061.00
11_V31_I0.8031.00
179_Q190_L0.8001.00
88_Q91_A0.7971.00
159_A162_R0.7961.00
140_F167_I0.7961.00
222_A227_P0.7951.00
99_R250_L0.7951.00
143_L241_L0.7931.00
242_L246_F0.7801.00
156_A160_R0.7761.00
137_R208_E0.7761.00
235_V239_F0.7761.00
49_D54_E0.7751.00
279_L292_L0.7751.00
73_K77_G0.7741.00
289_I293_A0.7721.00
68_T82_A0.7701.00
35_L303_F0.7701.00
75_T78_A0.7671.00
14_D19_K0.7641.00
266_T275_G0.7641.00
210_W215_K0.7611.00
219_D222_A0.7611.00
89_V92_Q0.7591.00
244_L247_Q0.7571.00
286_P289_I0.7551.00
277_H281_H0.7551.00
70_A82_A0.7551.00
202_R205_Q0.7551.00
93_K97_D0.7541.00
188_A195_T0.7511.00
104_E122_S0.7441.00
195_T198_R0.7431.00
15_R31_I0.7411.00
152_G156_A0.7401.00
169_D198_R0.7391.00
208_E211_A0.7361.00
210_W214_P0.7341.00
14_D289_I0.7321.00
192_E247_Q0.7311.00
52_N65_A0.7311.00
105_L238_M0.7311.00
35_L38_F0.7311.00
210_W216_P0.7301.00
94_I97_D0.7301.00
282_H289_I0.7301.00
196_S200_I0.7291.00
192_E195_T0.7211.00
207_A210_W0.7201.00
141_E145_G0.7201.00
73_K76_E0.7171.00
292_L295_I0.7151.00
216_P221_P0.7151.00
282_H285_D0.7101.00
198_R202_R0.7071.00
272_V294_K0.7071.00
19_K23_G0.7061.00
168_L197_V0.7061.00
53_A65_A0.7061.00
154_P157_R0.7041.00
268_P273_P0.7021.00
299_H302_Q0.7021.00
279_L288_K0.7011.00
289_I292_L0.6991.00
74_K78_A0.6921.00
34_P300_V0.6901.00
178_L181_R0.6891.00
232_E298_Y0.6881.00
21_G26_F0.6871.00
233_E237_L0.6851.00
220_A226_I0.6841.00
4_F90_A0.6841.00
259_G263_S0.6841.00
225_G228_P0.6831.00
120_T129_P0.6821.00
167_I170_S0.6811.00
28_L33_K0.6801.00
98_T249_D0.6751.00
189_K192_E0.6741.00
239_F242_L0.6731.00
106_G134_I0.6721.00
36_E40_D0.6721.00
172_L179_Q0.6711.00
149_P153_T0.6691.00
203_R233_E0.6671.00
272_V291_K0.6671.00
63_S261_E0.6661.00
157_R160_R0.6651.00
100_F104_E0.6631.00
288_K291_K0.6591.00
15_R290_A0.6581.00
206_R210_W0.6581.00
212_D216_P0.6551.00
294_K301_E0.6531.00
232_E302_Q0.6531.00
186_D189_K0.6511.00
173_E177_R0.6481.00
215_K219_D0.6461.00
211_A216_P0.6431.00
141_E222_A0.6431.00
37_P40_D0.6361.00
26_F29_S0.6361.00
274_D288_K0.6351.00
137_R140_F0.6341.00
272_V295_I0.6331.00
12_I31_I0.6321.00
293_A296_N0.6311.00
193_Y196_S0.6301.00
105_L256_F0.6301.00
171_V175_A0.6281.00
64_A82_A0.6251.00
63_S257_M0.6251.00
207_A211_A0.6231.00
16_W29_S0.6221.00
21_G24_A0.6221.00
6_Y62_G0.6221.00
11_V17_T0.6151.00
59_H281_H0.6141.00
136_P237_L0.6121.00
88_Q130_L0.6121.00
189_K196_S0.6111.00
97_D101_P0.6101.00
223_P228_P0.6081.00
212_D218_P0.6081.00
56_G61_R0.6081.00
149_P152_G0.6081.00
128_T192_E0.6081.00
103_L139_V0.6071.00
222_A225_G0.6041.00
29_S44_V0.6041.00
43_T46_S0.6011.00
213_T219_D0.6001.00
175_A193_Y0.5981.00
108_E259_G0.5981.00
278_P282_H0.5891.00
182_L194_L0.5891.00
169_D201_E0.5881.00
265_R269_E0.5861.00
231_F235_V0.5861.00
162_R208_E0.5841.00
224_P228_P0.5841.00
152_G155_A0.5831.00
219_D223_P0.5821.00
217_L223_P0.5771.00
132_P260_R0.5771.00
67_L255_T0.5761.00
100_F139_V0.5761.00
116_A119_N0.5731.00
18_P46_S0.5731.00
298_Y301_E0.5721.00
138_A142_R0.5721.00
57_G61_R0.5701.00
9_N12_I0.5701.00
218_P222_A0.5701.00
61_R71_H0.5701.00
192_E196_S0.5691.00
103_L245_A0.5671.00
153_T157_R0.5641.00
71_H74_K0.5631.00
179_Q182_L0.5601.00
98_T252_R0.5591.00
120_T130_L0.5581.00
2_F86_I0.5571.00
117_Y123_W0.5571.00
300_V303_F0.5571.00
107_V234_H0.5561.00
6_Y9_N0.5551.00
217_L221_P0.5541.00
9_N280_S0.5531.00
276_H295_I0.5521.00
25_D40_D0.5501.00
165_R205_Q0.5481.00
168_L194_L0.5481.00
231_F265_R0.5481.00
168_L198_R0.5471.00
269_E302_Q0.5461.00
73_K81_R0.5461.00
173_E180_R0.5441.00
101_P104_E0.5411.00
218_P224_P0.5391.00
177_R181_R0.5391.00
42_L300_V0.5381.00
5_V258_L0.5381.00
148_D152_G0.5371.00
81_R127_T0.5361.00
180_R183_G0.5361.00
50_H53_A0.5341.00
213_T248_T0.5341.00
215_K220_A0.5341.00
235_V302_Q0.5311.00
28_L38_F0.5311.00
221_P226_I0.5301.00
63_S121_I0.5281.00
165_R208_E0.5261.00
175_A190_L0.5241.00
243_A246_F0.5231.00
172_L194_L0.5211.00
198_R205_Q0.5211.00
285_D290_A0.5201.00
12_I292_L0.5191.00
168_L172_L0.5191.00
246_F251_T0.5191.00
19_K22_E0.5161.00
95_G101_P0.5141.00
183_G186_D0.5141.00
97_D206_R0.5131.00
91_A253_V0.5091.00
143_L245_A0.5081.00
193_Y197_V0.5071.00
67_L121_I0.5051.00
54_E62_G0.5041.00
276_H299_H0.5031.00
4_F255_T0.5021.00
53_A58_G0.5011.00
216_P248_T0.5001.00
209_A212_D0.5001.00
267_Y270_L0.5001.00
72_P82_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2h54A 1 0.1941 26.2 0.952 Contact Map
1uujA 2 0.1941 26 0.952 Contact Map
3zifN 3 0.352 17.9 0.956 Contact Map
4djgA 2 0.1711 17.5 0.956 Contact Map
2akfA 3 0.1053 14.2 0.958 Contact Map
1hulA 2 0.3355 11.6 0.959 Contact Map
2kwhA 1 0.1842 11.5 0.959 Contact Map
1txpA 3 0.0921 11.1 0.96 Contact Map
4n78F 1 0.3487 8.1 0.962 Contact Map
3vp9A 3 0.148 7.5 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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