HXXSHH - PFAM28P - GREMLIN Contacts

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HXXSHH - Protein of unknown function (DUF1552)

PFAM:	PF07586	Sequences: RFGFVYVPNGVIPDRWTPKGGEGADFELSPILKPLEPFRDDLTVLSGLDHPNAEAGGGHARGSAAFLTGAHPKKTEGADIRAGISIDQVAAQKIGQDTRFPSLELGVEGGGGYSCAYTNTISWRSPTTPLPPEINPRAVFERLFGDGDPGPGTPAARAARLRRRRSILDSVLEDAKRLQRRLGAADRAKLDEYLTSVREIERRIQRAEAWADTPKPLPDAPAPPGIPPEDFEEHVRLMFDLLALAFQTDLTRVATFMLGREGSNRTYPELGVPDGHHPLSHHGNDPEKIAKLAKINRYHVEQFA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	304 (300)
Sequences:	20672 (13242)
Seq/√Len:	764.5
META:	0.967

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_K	36_E	3.472	1.00
242_L	254_A	3.389	1.00
191_D	195_T	3.246	1.00
2_F	90_A	3.023	1.00
36_E	39_R	3.004	1.00
84_I	92_Q	2.950	1.00
68_T	85_S	2.847	1.00
105_L	139_V	2.809	1.00
230_D	233_E	2.768	1.00
249_D	252_R	2.679	1.00
179_Q	187_R	2.676	1.00
175_A	194_L	2.649	1.00
21_G	27_E	2.640	1.00
236_R	302_Q	2.482	1.00
297_R	301_E	2.377	1.00
195_T	199_E	2.316	1.00
172_L	176_K	2.316	1.00
3_G	246_F	2.286	1.00
133_E	138_A	2.181	1.00
176_K	179_Q	2.156	1.00
15_R	293_A	2.136	1.00
33_K	297_R	2.078	1.00
179_Q	191_D	2.071	1.00
285_D	288_K	2.025	1.00
213_T	216_P	2.007	1.00
184_A	187_R	1.999	1.00
166_S	198_R	1.997	1.00
133_E	142_R	1.986	1.00
286_P	290_A	1.981	1.00
29_S	32_L	1.968	1.00
274_D	291_K	1.949	1.00
198_R	201_E	1.931	1.00
290_A	294_K	1.888	1.00
32_L	44_V	1.855	1.00
235_V	258_L	1.839	1.00
21_G	25_D	1.826	1.00
139_V	241_L	1.813	1.00
124_R	128_T	1.787	1.00
106_G	132_P	1.777	1.00
38_F	42_L	1.766	1.00
184_A	188_A	1.752	1.00
90_A	253_V	1.732	1.00
12_I	15_R	1.723	1.00
158_A	162_R	1.721	1.00
92_Q	125_S	1.712	1.00
206_R	209_A	1.701	1.00
232_E	269_E	1.688	1.00
280_S	292_L	1.673	1.00
15_R	30_P	1.666	1.00
215_K	218_P	1.661	1.00
287_E	290_A	1.615	1.00
214_P	217_L	1.602	1.00
84_I	89_V	1.589	1.00
38_F	41_D	1.585	1.00
153_T	156_A	1.580	1.00
125_S	128_T	1.576	1.00
104_E	130_L	1.573	1.00
107_V	235_V	1.568	1.00
246_F	254_A	1.550	1.00
17_T	46_S	1.532	1.00
137_R	141_E	1.532	1.00
12_I	289_I	1.516	1.00
30_P	33_K	1.515	1.00
174_D	177_R	1.506	1.00
89_V	93_K	1.498	1.00
19_K	29_S	1.494	1.00
19_K	27_E	1.489	1.00
220_A	223_P	1.488	1.00
93_K	96_Q	1.483	1.00
177_R	180_R	1.477	1.00
292_L	296_N	1.469	1.00
23_G	26_F	1.460	1.00
4_F	86_I	1.452	1.00
239_F	258_L	1.449	1.00
182_L	190_L	1.447	1.00
92_Q	101_P	1.436	1.00
166_S	201_E	1.425	1.00
13_P	17_T	1.421	1.00
5_V	239_F	1.412	1.00
202_R	206_R	1.408	1.00
51_P	54_E	1.405	1.00
100_F	250_L	1.400	1.00
28_L	42_L	1.396	1.00
216_P	219_D	1.395	1.00
24_A	40_D	1.390	1.00
135_N	138_A	1.388	1.00
7_V	11_V	1.364	1.00
185_A	188_A	1.340	1.00
233_E	236_R	1.300	1.00
52_N	71_H	1.293	1.00
232_E	301_E	1.290	1.00
45_L	48_L	1.289	1.00
122_S	130_L	1.284	1.00
200_I	244_L	1.280	1.00
86_I	90_A	1.280	1.00
293_A	297_R	1.280	1.00
294_K	297_R	1.275	1.00
84_I	126_P	1.268	1.00
88_Q	102_S	1.267	1.00
159_A	163_R	1.245	1.00
199_E	202_R	1.239	1.00
158_A	161_L	1.236	1.00
103_L	143_L	1.232	1.00
269_E	298_Y	1.230	1.00
210_W	213_T	1.227	1.00
30_P	297_R	1.215	1.00
92_Q	124_R	1.205	1.00
243_A	247_Q	1.199	1.00
34_P	297_R	1.190	1.00
173_E	176_K	1.184	1.00
223_P	226_I	1.181	1.00
28_L	39_R	1.170	1.00
90_A	94_I	1.165	1.00
34_P	37_P	1.140	1.00
166_S	169_D	1.139	1.00
133_E	139_V	1.138	1.00
205_Q	208_E	1.138	1.00
25_D	39_R	1.134	1.00
81_R	126_P	1.131	1.00
139_V	238_M	1.128	1.00
75_T	79_D	1.128	1.00
73_K	79_D	1.127	1.00
239_F	243_A	1.124	1.00
212_D	215_K	1.124	1.00
35_L	42_L	1.121	1.00
26_F	39_R	1.113	1.00
50_H	65_A	1.111	1.00
291_K	294_K	1.103	1.00
155_A	159_A	1.101	1.00
188_A	192_E	1.087	1.00
160_R	163_R	1.087	1.00
287_E	291_K	1.084	1.00
27_E	36_E	1.083	1.00
211_A	214_P	1.082	1.00
195_T	202_R	1.082	1.00
203_R	240_D	1.076	1.00
232_E	236_R	1.076	1.00
27_E	33_K	1.075	1.00
28_L	36_E	1.068	1.00
138_A	141_E	1.065	1.00
40_D	43_T	1.062	1.00
240_D	243_A	1.046	1.00
155_A	158_A	1.042	1.00
221_P	224_P	1.039	1.00
154_P	158_A	1.036	1.00
199_E	203_R	1.029	1.00
5_V	303_F	1.028	1.00
30_P	290_A	1.024	1.00
3_G	254_A	1.020	1.00
176_K	180_R	1.011	1.00
90_A	93_K	1.007	1.00
31_I	296_N	1.002	1.00
3_G	242_L	0.998	1.00
275_G	278_P	0.996	1.00
297_R	300_V	0.986	1.00
156_A	159_A	0.985	1.00
205_Q	209_A	0.976	1.00
22_E	25_D	0.975	1.00
279_L	291_K	0.974	1.00
213_T	217_L	0.970	1.00
236_R	240_D	0.969	1.00
175_A	179_Q	0.968	1.00
94_I	253_V	0.964	1.00
179_Q	194_L	0.964	1.00
242_L	256_F	0.964	1.00
214_P	218_P	0.963	1.00
26_F	42_L	0.959	1.00
276_H	280_S	0.957	1.00
105_L	242_L	0.955	1.00
95_G	98_T	0.952	1.00
57_G	60_A	0.952	1.00
211_A	215_K	0.946	1.00
21_G	29_S	0.945	1.00
107_V	238_M	0.944	1.00
179_Q	195_T	0.942	1.00
34_P	301_E	0.939	1.00
274_D	278_P	0.936	1.00
213_T	218_P	0.936	1.00
271_G	294_K	0.933	1.00
124_R	130_L	0.926	1.00
230_D	269_E	0.925	1.00
120_T	132_P	0.923	1.00
272_V	279_L	0.922	1.00
70_A	83_G	0.917	1.00
188_A	191_D	0.916	1.00
296_N	299_H	0.915	1.00
143_L	250_L	0.915	1.00
211_A	217_L	0.915	1.00
279_L	295_I	0.914	1.00
223_P	227_P	0.910	1.00
172_L	175_A	0.908	1.00
91_A	102_S	0.908	1.00
224_P	227_P	0.907	1.00
103_L	254_A	0.907	1.00
267_Y	299_H	0.906	1.00
234_H	238_M	0.904	1.00
290_A	293_A	0.904	1.00
30_P	293_A	0.892	1.00
222_A	226_I	0.892	1.00
170_S	174_D	0.890	1.00
283_G	288_K	0.888	1.00
264_N	278_P	0.885	1.00
31_I	34_P	0.884	1.00
282_H	288_K	0.884	1.00
104_E	255_T	0.871	1.00
162_R	165_R	0.866	1.00
217_L	220_A	0.865	1.00
4_F	67_L	0.865	1.00
264_N	275_G	0.861	1.00
100_F	105_L	0.859	1.00
4_F	66_F	0.850	1.00
157_R	161_L	0.846	1.00
58_G	61_R	0.840	1.00
31_I	293_A	0.840	1.00
31_I	297_R	0.838	1.00
35_L	300_V	0.836	1.00
298_Y	302_Q	0.834	1.00
221_P	227_P	0.829	1.00
274_D	279_L	0.829	1.00
178_L	190_L	0.827	1.00
104_E	142_R	0.827	1.00
74_K	77_G	0.823	1.00
27_E	39_R	0.822	1.00
84_I	125_S	0.821	1.00
273_P	291_K	0.819	1.00
218_P	221_P	0.818	1.00
50_H	69_G	0.816	1.00
239_F	256_F	0.814	1.00
122_S	255_T	0.814	1.00
22_E	26_F	0.811	1.00
245_A	251_T	0.807	1.00
209_A	213_T	0.806	1.00
11_V	31_I	0.803	1.00
179_Q	190_L	0.800	1.00
88_Q	91_A	0.797	1.00
159_A	162_R	0.796	1.00
140_F	167_I	0.796	1.00
222_A	227_P	0.795	1.00
99_R	250_L	0.795	1.00
143_L	241_L	0.793	1.00
242_L	246_F	0.780	1.00
156_A	160_R	0.776	1.00
137_R	208_E	0.776	1.00
235_V	239_F	0.776	1.00
49_D	54_E	0.775	1.00
279_L	292_L	0.775	1.00
73_K	77_G	0.774	1.00
289_I	293_A	0.772	1.00
68_T	82_A	0.770	1.00
35_L	303_F	0.770	1.00
75_T	78_A	0.767	1.00
14_D	19_K	0.764	1.00
266_T	275_G	0.764	1.00
210_W	215_K	0.761	1.00
219_D	222_A	0.761	1.00
89_V	92_Q	0.759	1.00
244_L	247_Q	0.757	1.00
286_P	289_I	0.755	1.00
277_H	281_H	0.755	1.00
70_A	82_A	0.755	1.00
202_R	205_Q	0.755	1.00
93_K	97_D	0.754	1.00
188_A	195_T	0.751	1.00
104_E	122_S	0.744	1.00
195_T	198_R	0.743	1.00
15_R	31_I	0.741	1.00
152_G	156_A	0.740	1.00
169_D	198_R	0.739	1.00
208_E	211_A	0.736	1.00
210_W	214_P	0.734	1.00
14_D	289_I	0.732	1.00
192_E	247_Q	0.731	1.00
52_N	65_A	0.731	1.00
105_L	238_M	0.731	1.00
35_L	38_F	0.731	1.00
210_W	216_P	0.730	1.00
94_I	97_D	0.730	1.00
282_H	289_I	0.730	1.00
196_S	200_I	0.729	1.00
192_E	195_T	0.721	1.00
207_A	210_W	0.720	1.00
141_E	145_G	0.720	1.00
73_K	76_E	0.717	1.00
292_L	295_I	0.715	1.00
216_P	221_P	0.715	1.00
282_H	285_D	0.710	1.00
198_R	202_R	0.707	1.00
272_V	294_K	0.707	1.00
19_K	23_G	0.706	1.00
168_L	197_V	0.706	1.00
53_A	65_A	0.706	1.00
154_P	157_R	0.704	1.00
268_P	273_P	0.702	1.00
299_H	302_Q	0.702	1.00
279_L	288_K	0.701	1.00
289_I	292_L	0.699	1.00
74_K	78_A	0.692	1.00
34_P	300_V	0.690	1.00
178_L	181_R	0.689	1.00
232_E	298_Y	0.688	1.00
21_G	26_F	0.687	1.00
233_E	237_L	0.685	1.00
220_A	226_I	0.684	1.00
4_F	90_A	0.684	1.00
259_G	263_S	0.684	1.00
225_G	228_P	0.683	1.00
120_T	129_P	0.682	1.00
167_I	170_S	0.681	1.00
28_L	33_K	0.680	1.00
98_T	249_D	0.675	1.00
189_K	192_E	0.674	1.00
239_F	242_L	0.673	1.00
106_G	134_I	0.672	1.00
36_E	40_D	0.672	1.00
172_L	179_Q	0.671	1.00
149_P	153_T	0.669	1.00
203_R	233_E	0.667	1.00
272_V	291_K	0.667	1.00
63_S	261_E	0.666	1.00
157_R	160_R	0.665	1.00
100_F	104_E	0.663	1.00
288_K	291_K	0.659	1.00
15_R	290_A	0.658	1.00
206_R	210_W	0.658	1.00
212_D	216_P	0.655	1.00
294_K	301_E	0.653	1.00
232_E	302_Q	0.653	1.00
186_D	189_K	0.651	1.00
173_E	177_R	0.648	1.00
215_K	219_D	0.646	1.00
211_A	216_P	0.643	1.00
141_E	222_A	0.643	1.00
37_P	40_D	0.636	1.00
26_F	29_S	0.636	1.00
274_D	288_K	0.635	1.00
137_R	140_F	0.634	1.00
272_V	295_I	0.633	1.00
12_I	31_I	0.632	1.00
293_A	296_N	0.631	1.00
193_Y	196_S	0.630	1.00
105_L	256_F	0.630	1.00
171_V	175_A	0.628	1.00
64_A	82_A	0.625	1.00
63_S	257_M	0.625	1.00
207_A	211_A	0.623	1.00
16_W	29_S	0.622	1.00
21_G	24_A	0.622	1.00
6_Y	62_G	0.622	1.00
11_V	17_T	0.615	1.00
59_H	281_H	0.614	1.00
136_P	237_L	0.612	1.00
88_Q	130_L	0.612	1.00
189_K	196_S	0.611	1.00
97_D	101_P	0.610	1.00
223_P	228_P	0.608	1.00
212_D	218_P	0.608	1.00
56_G	61_R	0.608	1.00
149_P	152_G	0.608	1.00
128_T	192_E	0.608	1.00
103_L	139_V	0.607	1.00
222_A	225_G	0.604	1.00
29_S	44_V	0.604	1.00
43_T	46_S	0.601	1.00
213_T	219_D	0.600	1.00
175_A	193_Y	0.598	1.00
108_E	259_G	0.598	1.00
278_P	282_H	0.589	1.00
182_L	194_L	0.589	1.00
169_D	201_E	0.588	1.00
265_R	269_E	0.586	1.00
231_F	235_V	0.586	1.00
162_R	208_E	0.584	1.00
224_P	228_P	0.584	1.00
152_G	155_A	0.583	1.00
219_D	223_P	0.582	1.00
217_L	223_P	0.577	1.00
132_P	260_R	0.577	1.00
67_L	255_T	0.576	1.00
100_F	139_V	0.576	1.00
116_A	119_N	0.573	1.00
18_P	46_S	0.573	1.00
298_Y	301_E	0.572	1.00
138_A	142_R	0.572	1.00
57_G	61_R	0.570	1.00
9_N	12_I	0.570	1.00
218_P	222_A	0.570	1.00
61_R	71_H	0.570	1.00
192_E	196_S	0.569	1.00
103_L	245_A	0.567	1.00
153_T	157_R	0.564	1.00
71_H	74_K	0.563	1.00
179_Q	182_L	0.560	1.00
98_T	252_R	0.559	1.00
120_T	130_L	0.558	1.00
2_F	86_I	0.557	1.00
117_Y	123_W	0.557	1.00
300_V	303_F	0.557	1.00
107_V	234_H	0.556	1.00
6_Y	9_N	0.555	1.00
217_L	221_P	0.554	1.00
9_N	280_S	0.553	1.00
276_H	295_I	0.552	1.00
25_D	40_D	0.550	1.00
165_R	205_Q	0.548	1.00
168_L	194_L	0.548	1.00
231_F	265_R	0.548	1.00
168_L	198_R	0.547	1.00
269_E	302_Q	0.546	1.00
73_K	81_R	0.546	1.00
173_E	180_R	0.544	1.00
101_P	104_E	0.541	1.00
218_P	224_P	0.539	1.00
177_R	181_R	0.539	1.00
42_L	300_V	0.538	1.00
5_V	258_L	0.538	1.00
148_D	152_G	0.537	1.00
81_R	127_T	0.536	1.00
180_R	183_G	0.536	1.00
50_H	53_A	0.534	1.00
213_T	248_T	0.534	1.00
215_K	220_A	0.534	1.00
235_V	302_Q	0.531	1.00
28_L	38_F	0.531	1.00
221_P	226_I	0.530	1.00
63_S	121_I	0.528	1.00
165_R	208_E	0.526	1.00
175_A	190_L	0.524	1.00
243_A	246_F	0.523	1.00
172_L	194_L	0.521	1.00
198_R	205_Q	0.521	1.00
285_D	290_A	0.520	1.00
12_I	292_L	0.519	1.00
168_L	172_L	0.519	1.00
246_F	251_T	0.519	1.00
19_K	22_E	0.516	1.00
95_G	101_P	0.514	1.00
183_G	186_D	0.514	1.00
97_D	206_R	0.513	1.00
91_A	253_V	0.509	1.00
143_L	245_A	0.508	1.00
193_Y	197_V	0.507	1.00
67_L	121_I	0.505	1.00
54_E	62_G	0.504	1.00
276_H	299_H	0.503	1.00
4_F	255_T	0.502	1.00
53_A	58_G	0.501	1.00
216_P	248_T	0.500	1.00
209_A	212_D	0.500	1.00
267_Y	270_L	0.500	1.00
72_P	82_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2h54A	1	0.1941	26.2	0.952	Contact Map
1uujA	2	0.1941	26	0.952	Contact Map
3zifN	3	0.352	17.9	0.956	Contact Map
4djgA	2	0.1711	17.5	0.956	Contact Map
2akfA	3	0.1053	14.2	0.958	Contact Map
1hulA	2	0.3355	11.6	0.959	Contact Map
2kwhA	1	0.1842	11.5	0.959	Contact Map
1txpA	3	0.0921	11.1	0.96	Contact Map
4n78F	1	0.3487	8.1	0.962	Contact Map
3vp9A	3	0.148	7.5	0.962	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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