GREMLIN Database
PSCyt2 - Protein of unknown function (DUF1549)
PFAM: PF07583 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 208 (206)
Sequences: 52489 (29806)
Seq/√Len: 2076.7
META: 0.966

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_R111_A3.4711.00
119_V174_F3.0491.00
43_E62_R3.0391.00
27_L59_L3.0181.00
70_G110_N2.9901.00
22_D25_T2.9211.00
9_K13_E2.8591.00
113_K121_E2.8201.00
52_S58_K2.7491.00
54_D58_K2.4551.00
45_D49_A2.4231.00
40_T43_E2.3951.00
108_A113_K2.3871.00
30_V56_Y2.2771.00
31_Y63_L2.1251.00
26_L56_Y2.1191.00
23_R51_T2.0401.00
9_K12_A2.0271.00
7_L10_L1.9681.00
35_T63_L1.9671.00
117_Q121_E1.9191.00
196_D199_S1.9041.00
46_A62_R1.8911.00
117_Q120_R1.8701.00
50_D58_K1.8651.00
42_E46_A1.8521.00
27_L31_Y1.8411.00
24_R48_L1.8071.00
27_L44_V1.8031.00
171_G179_V1.7961.00
7_L11_E1.7861.00
59_L62_R1.7611.00
6_V10_L1.7471.00
31_Y35_T1.7411.00
41_P45_D1.7381.00
168_D180_G1.7211.00
121_E135_Q1.6911.00
35_T68_H1.6491.00
62_R66_S1.6461.00
47_F55_A1.6351.00
104_W121_E1.6231.00
7_L17_P1.6081.00
171_G175_L1.6051.00
107_R134_E1.5851.00
31_Y59_L1.5571.00
80_L173_V1.5491.00
78_L105_V1.5251.00
21_A25_T1.5071.00
54_D57_E1.4941.00
8_A12_A1.4931.00
113_K117_Q1.4661.00
32_L38_P1.4501.00
44_V48_L1.4461.00
168_D183_R1.4341.00
23_R55_A1.4181.00
195_K199_S1.4011.00
35_T66_S1.3761.00
201_A205_A1.3581.00
186_D194_Q1.3531.00
164_D168_D1.3471.00
132_T135_Q1.3391.00
153_A158_F1.3331.00
24_R44_V1.3191.00
30_V59_L1.3121.00
67_P110_N1.3021.00
133_P136_L1.2951.00
164_D183_R1.2911.00
45_D48_L1.2881.00
177_L192_I1.2761.00
30_V60_V1.2561.00
61_D65_A1.2551.00
26_L30_V1.2521.00
170_T173_V1.2371.00
10_L17_P1.2351.00
115_Y119_V1.2221.00
43_E66_S1.2201.00
87_N93_R1.2111.00
172_Q180_G1.2111.00
161_D183_R1.2061.00
170_T204_F1.2011.00
72_R76_H1.2001.00
68_H71_E1.1921.00
8_A11_E1.1921.00
157_E161_D1.1901.00
131_A136_L1.1801.00
31_Y43_E1.1741.00
168_D197_Y1.1721.00
105_V118_F1.1711.00
120_R128_L1.1671.00
23_R50_D1.1491.00
70_G74_A1.1371.00
158_F162_Y1.1211.00
160_V201_A1.1141.00
59_L63_L1.1061.00
71_E106_I1.0861.00
148_N153_A1.0721.00
56_Y60_V1.0721.00
104_W113_K1.0611.00
73_W76_H1.0471.00
113_K134_E1.0441.00
50_D53_P1.0201.00
41_P44_V1.0131.00
103_D107_R1.0091.00
69_Y73_W1.0081.00
91_K149_G1.0081.00
168_D172_Q1.0001.00
116_D120_R0.9911.00
50_D55_A0.9911.00
6_V17_P0.9841.00
142_L170_T0.9751.00
186_D193_T0.9711.00
159_R163_V0.9641.00
163_V201_A0.9551.00
94_P97_N0.9531.00
149_G158_F0.9491.00
4_R8_A0.9471.00
31_Y40_T0.9371.00
131_A135_Q0.9241.00
97_N100_R0.9241.00
156_E159_R0.9221.00
73_W109_F0.9121.00
118_F122_Q0.9111.00
129_P132_T0.8811.00
87_N147_T0.8801.00
121_E128_L0.8781.00
72_R75_R0.8771.00
50_D62_R0.8761.00
123_L174_F0.8751.00
149_G153_A0.8701.00
152_G155_P0.8651.00
155_P158_F0.8641.00
30_V63_L0.8631.00
43_E46_A0.8621.00
56_Y59_L0.8581.00
111_A134_E0.8541.00
158_F161_D0.8471.00
179_V182_A0.8461.00
154_D157_E0.8431.00
101_Y122_Q0.8431.00
51_T54_D0.8411.00
202_A206_N0.8371.00
156_E160_V0.8361.00
147_T158_F0.8351.00
42_E45_D0.8351.00
37_L68_H0.8301.00
31_Y62_R0.8291.00
87_N91_K0.8281.00
136_L139_T0.8261.00
81_A101_Y0.8211.00
43_E59_L0.8191.00
123_L170_T0.8181.00
149_G155_P0.8171.00
20_E56_Y0.8131.00
81_A141_F0.8121.00
171_G200_L0.8121.00
87_N149_G0.8071.00
106_I110_N0.8051.00
87_N90_E0.8021.00
87_N95_R0.7921.00
147_T151_G0.7901.00
10_L13_E0.7831.00
154_D158_F0.7761.00
186_D195_K0.7641.00
160_V164_D0.7631.00
23_R56_Y0.7621.00
91_K151_G0.7551.00
74_A105_V0.7551.00
74_A106_I0.7501.00
78_L83_Y0.7471.00
93_R149_G0.7471.00
21_A26_L0.7441.00
151_G154_D0.7431.00
114_P117_Q0.7411.00
91_K94_P0.7381.00
141_F169_T0.7371.00
23_R53_P0.7321.00
150_E155_P0.7291.00
179_V200_L0.7211.00
44_V47_F0.7201.00
150_E153_A0.7181.00
57_E61_D0.7171.00
150_E154_D0.7171.00
136_L140_G0.7151.00
163_V167_V0.7151.00
129_P135_Q0.7141.00
23_R47_F0.7081.00
200_L203_F0.7041.00
130_P135_Q0.6941.00
113_K118_F0.6911.00
44_V59_L0.6851.00
104_W108_A0.6821.00
90_E94_P0.6771.00
27_L47_F0.6771.00
91_K95_R0.6761.00
194_Q198_Y0.6741.00
151_G155_P0.6721.00
167_V200_L0.6711.00
148_N158_F0.6701.00
107_R137_I0.6681.00
70_G106_I0.6671.00
48_L51_T0.6661.00
166_R170_T0.6611.00
151_G158_F0.6601.00
182_A192_I0.6591.00
108_A118_F0.6581.00
77_W109_F0.6531.00
152_G158_F0.6461.00
108_A121_E0.6441.00
152_G156_E0.6391.00
147_T155_P0.6371.00
160_V163_V0.6341.00
48_L55_A0.6301.00
51_T56_Y0.6281.00
23_R48_L0.6281.00
117_Q135_Q0.6271.00
34_L63_L0.6241.00
5_F8_A0.6231.00
149_G154_D0.6231.00
100_R107_R0.6221.00
199_S202_A0.6221.00
27_L48_L0.6221.00
87_N94_P0.6211.00
139_T142_L0.6171.00
147_T153_A0.6171.00
161_D164_D0.6151.00
133_P137_I0.6131.00
164_D197_Y0.6121.00
154_D162_Y0.6111.00
11_E16_K0.6111.00
148_N162_Y0.6111.00
152_G157_E0.6071.00
146_P153_A0.6061.00
167_V201_A0.6031.00
167_V171_G0.6021.00
140_G144_L0.6001.00
115_Y118_F0.6001.00
93_R147_T0.5991.00
148_N152_G0.5981.00
10_L15_L0.5981.00
170_T174_F0.5961.00
46_A50_D0.5951.00
47_F56_Y0.5951.00
153_A156_E0.5951.00
47_F50_D0.5951.00
159_R162_Y0.5901.00
148_N151_G0.5891.00
37_L66_S0.5881.00
20_E26_L0.5871.00
62_R65_A0.5861.00
23_R54_D0.5861.00
91_K148_N0.5841.00
84_A88_G0.5821.00
82_R169_T0.5811.00
119_V173_V0.5811.00
157_E160_V0.5761.00
90_E147_T0.5751.00
148_N154_D0.5741.00
127_L130_P0.5721.00
85_D89_Y0.5721.00
162_Y165_D0.5711.00
193_T196_D0.5711.00
148_N155_P0.5671.00
146_P158_F0.5661.00
51_T55_A0.5641.00
60_V64_L0.5611.00
50_D54_D0.5601.00
89_Y158_F0.5591.00
35_T43_E0.5581.00
46_A59_L0.5581.00
153_A157_E0.5561.00
20_E23_R0.5561.00
31_Y34_L0.5491.00
55_A59_L0.5481.00
170_T200_L0.5471.00
91_K158_F0.5461.00
26_L59_L0.5441.00
87_N150_E0.5431.00
91_K146_P0.5431.00
51_T58_K0.5421.00
32_L72_R0.5421.00
52_S55_A0.5401.00
75_R79_D0.5391.00
24_R27_L0.5391.00
83_Y105_V0.5391.00
4_R7_L0.5381.00
115_Y174_F0.5371.00
6_V9_K0.5351.00
90_E93_R0.5351.00
146_P162_Y0.5321.00
58_K61_D0.5321.00
155_P159_R0.5301.00
134_E137_I0.5271.00
26_L60_V0.5271.00
23_R52_S0.5251.00
90_E153_A0.5241.00
105_V122_Q0.5221.00
24_R45_D0.5211.00
4_R11_E0.5181.00
147_T162_Y0.5171.00
136_L142_L0.5141.00
140_G143_R0.5141.00
147_T152_G0.5121.00
120_R129_P0.5111.00
79_D83_Y0.5091.00
70_G109_F0.5091.00
150_E158_F0.5081.00
99_W103_D0.5031.00
5_F9_K0.5011.00
23_R26_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3osjA 1 0.3942 51.6 0.942 Contact Map
3sjlA 1 0.7067 46.6 0.943 Contact Map
2c1vA 2 0.75 36 0.947 Contact Map
3hq9A 2 0.75 33.6 0.948 Contact Map
3nphB 1 0.3942 30.6 0.949 Contact Map
3ohwB 1 0.3942 30.1 0.949 Contact Map
3pruC 1 0.4519 27.1 0.95 Contact Map
1hroA 1 0.2163 26.4 0.951 Contact Map
4eieA 1 0.1827 20.3 0.953 Contact Map
4wqdA 1 0.2981 20.3 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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