GREMLIN Database
BCNT - Bucentaur or craniofacial development
PFAM: PF07572 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (71)
Sequences: 577 (409)
Seq/√Len: 48.5
META: 0.423

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_Q59_Q3.2131.00
61_V65_R2.7581.00
52_L56_D2.6471.00
66_F69_E2.4711.00
23_K27_D2.0601.00
31_F37_I1.9930.99
66_F70_R1.9660.99
70_R73_R1.9200.99
70_R74_L1.8710.99
21_L45_N1.8200.99
42_E45_N1.7660.99
29_A32_K1.7370.99
3_G6_S1.6760.98
24_S50_G1.4910.96
44_H54_K1.4800.96
9_A13_A1.4580.96
29_A33_D1.4480.95
58_L62_D1.4320.95
71_D74_L1.3250.93
39_D42_E1.3030.92
33_D38_K1.2910.92
69_E73_R1.2900.92
32_K66_F1.2880.92
21_L69_E1.2580.91
24_S72_A1.2170.89
18_L26_L1.1890.88
40_E47_G1.1330.85
62_D69_E1.1260.85
32_K65_R1.1130.84
59_Q62_D1.0850.83
37_I41_L1.0820.83
3_G11_L1.0700.82
49_D54_K1.0670.82
50_G53_E1.0530.81
43_A46_K1.0430.80
63_A67_E1.0280.79
19_S52_L1.0260.79
47_G53_E1.0020.77
54_K74_L0.9950.77
18_L23_K0.9620.74
60_R64_R0.9600.74
65_R68_E0.9590.74
24_S35_E0.9560.74
14_K21_L0.9370.72
8_L32_K0.9350.72
33_D36_G0.9330.72
67_E71_D0.9230.71
20_T65_R0.8990.69
22_E38_K0.8940.69
68_E71_D0.8770.67
62_D66_F0.8700.67
7_L63_A0.8520.65
4_L7_L0.8460.65
15_K21_L0.8450.64
19_S68_E0.8350.64
25_K31_F0.8190.62
32_K41_L0.8160.62
22_E25_K0.8110.61
59_Q63_A0.7730.58
45_N50_G0.7530.56
20_T29_A0.7520.55
5_D35_E0.7440.55
21_L26_L0.7330.54
61_V64_R0.7230.53
8_L11_L0.7120.51
49_D63_A0.7090.51
19_S62_D0.7070.51
25_K61_V0.7070.51
37_I45_N0.6780.48
64_R68_E0.6740.48
3_G7_L0.6740.48
20_T60_R0.6710.47
21_L24_S0.6700.47
38_K43_A0.6610.46
32_K37_I0.6560.46
38_K42_E0.6520.45
19_S29_A0.6520.45
42_E46_K0.6510.45
10_Q56_D0.6450.45
31_F34_K0.6260.43
19_S67_E0.6230.43
23_K26_L0.6210.42
39_D60_R0.6170.42
62_D65_R0.6110.41
32_K45_N0.6060.41
43_A48_K0.5980.40
10_Q49_D0.5910.39
17_K41_L0.5860.39
20_T53_E0.5800.38
55_Q61_V0.5670.37
19_S60_R0.5670.37
9_A48_K0.5650.37
24_S52_L0.5640.37
26_L31_F0.5630.37
38_K67_E0.5610.37
64_R67_E0.5610.37
66_F74_L0.5600.36
32_K44_H0.5600.36
17_K22_E0.5540.36
30_S38_K0.5390.34
24_S27_D0.5210.33
6_S40_E0.5170.33
36_G73_R0.5160.32
3_G35_E0.5060.32
31_F64_R0.5020.31
61_V66_F0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ejfA 1 0.4133 4.4 0.907 Contact Map
3s4rA 2 0.5733 2.8 0.916 Contact Map
3aa0A 1 0.44 2.7 0.917 Contact Map
3q3wA 1 0.12 2.6 0.917 Contact Map
3h4sE 1 0.6 2.5 0.918 Contact Map
4mspA 2 0.76 2.3 0.92 Contact Map
1r9dA 2 0.6533 2.3 0.92 Contact Map
4twcA 1 0.44 2 0.921 Contact Map
1y1xA 2 0.8533 1.9 0.923 Contact Map
4mzjA 1 0.9867 1.9 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0048 seconds.