GREMLIN Database
DUF1542 - Domain of Unknown Function (DUF1542)
PFAM: PF07564 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (67)
Sequences: 3612 (1983)
Seq/√Len: 242.2
META: 0.501

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_D20_K2.7931.00
13_D17_A2.1551.00
26_A57_V1.9351.00
2_K24_D1.9121.00
27_A31_K1.8711.00
17_A21_A1.8191.00
12_T15_E1.7811.00
39_T42_A1.7611.00
41_D45_Q1.5981.00
3_A7_A1.5931.00
28_D32_A1.5781.00
26_A29_A1.4921.00
21_A25_A1.4641.00
47_K51_I1.4591.00
45_Q49_N1.4581.00
30_A50_G1.4441.00
33_A36_N1.3971.00
32_A36_N1.3971.00
18_A22_E1.3471.00
52_T56_A1.3341.00
24_D28_D1.3221.00
48_T52_T1.2681.00
46_A50_G1.2341.00
46_A49_N1.2321.00
49_N53_A1.2001.00
25_A29_A1.1861.00
37_A46_A1.1761.00
1_K4_E1.1601.00
40_N44_D1.0901.00
53_A56_A1.0891.00
62_V65_P1.0641.00
38_T42_A1.0551.00
22_E25_A1.0461.00
29_A33_A1.0081.00
8_D11_L1.0071.00
40_N43_V0.9991.00
43_V47_K0.9771.00
44_D48_T0.9771.00
19_A59_P0.9661.00
44_D47_K0.9631.00
31_K35_D0.9471.00
62_V66_A0.9381.00
30_A33_A0.9331.00
5_I23_V0.9251.00
4_E58_N0.9181.00
52_T55_N0.9061.00
28_D31_K0.9051.00
3_A6_D0.8971.00
29_A32_A0.8971.00
63_A66_A0.8841.00
26_A53_A0.8810.99
18_A21_A0.8730.99
8_D61_A0.8650.99
21_A24_D0.8640.99
23_V27_A0.8540.99
20_K24_D0.8480.99
42_A45_Q0.8420.99
58_N61_A0.8370.99
2_K20_K0.8360.99
2_K6_D0.8330.99
32_A35_D0.8320.99
22_E26_A0.8270.99
6_D16_K0.8200.99
11_L19_A0.8090.99
5_I16_K0.8030.99
19_A22_E0.7900.99
2_K23_V0.7830.99
8_D19_A0.7770.99
19_A57_V0.7760.99
19_A58_N0.7650.99
25_A28_D0.7540.98
26_A30_A0.7390.98
49_N52_T0.7360.98
61_A65_P0.7260.98
14_E17_A0.7260.98
20_K23_V0.7240.98
14_E18_A0.7180.98
1_K11_L0.6980.97
51_I55_N0.6690.97
1_K58_N0.6680.97
4_E7_A0.6610.96
45_Q48_T0.6580.96
41_D44_D0.6540.96
8_D58_N0.6510.96
19_A60_P0.6370.96
33_A46_A0.6200.95
23_V57_V0.5850.93
15_E18_A0.5710.92
37_A43_V0.5640.92
24_D27_A0.5620.92
11_L61_A0.5620.92
11_L15_E0.5530.91
22_E57_V0.5510.91
13_D16_K0.5490.91
1_K59_P0.5470.90
1_K57_V0.5460.90
27_A34_I0.5390.90
9_P16_K0.5330.89
37_A42_A0.5260.89
48_T51_I0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dgjA 4 0.6324 38.7 0.726 Contact Map
2ynqA 2 0.6029 34.8 0.733 Contact Map
4kjmA 4 0.6471 29.6 0.742 Contact Map
4gwpC 1 0 18.7 0.765 Contact Map
1zdaA 1 0.3824 5.7 0.814 Contact Map
2marA 1 0.6471 5.5 0.815 Contact Map
2j5yA 1 0.7647 5.5 0.816 Contact Map
1l6xB 1 0.3971 4.1 0.827 Contact Map
1gjsA 1 0.7941 3.6 0.832 Contact Map
2fs1A 1 0.7941 3.5 0.832 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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