GREMLIN Database
DUF1538 - Protein of unknown function (DUF1538)
PFAM: PF07556 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 211 (210)
Sequences: 8850 (5037)
Seq/√Len: 347.6
META: 0.884

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_I131_L3.4931.00
135_G199_L3.3651.00
7_I11_F3.2471.00
69_G119_V3.1281.00
70_F116_A3.0831.00
161_T198_S3.0021.00
130_Y134_P2.8451.00
120_L124_F2.8281.00
66_L116_A2.8221.00
141_I145_F2.8111.00
142_L207_I2.6311.00
139_V199_L2.5691.00
63_W67_L2.4061.00
87_A103_L2.3931.00
101_K105_L2.3691.00
88_K100_A2.3211.00
127_P130_Y2.3211.00
83_L107_V2.2921.00
31_I35_T2.2491.00
202_I206_L2.1901.00
137_L141_I2.1001.00
146_A206_L2.0741.00
131_L196_L2.0051.00
74_F105_L1.9731.00
91_E100_A1.9691.00
8_F11_F1.9541.00
70_F112_G1.9511.00
166_T197_A1.9001.00
102_G208_L1.8921.00
117_L131_L1.8031.00
6_L10_L1.7911.00
2_V27_L1.7831.00
17_I21_L1.7751.00
129_H133_I1.7751.00
69_G115_I1.7321.00
90_V153_I1.7221.00
50_E54_S1.6941.00
99_P102_G1.6681.00
20_L24_L1.6551.00
21_L25_I1.6441.00
159_G198_S1.6241.00
24_L28_V1.6111.00
77_T198_S1.6081.00
132_L195_A1.5941.00
25_I29_L1.5941.00
146_A210_L1.5941.00
106_T204_A1.5731.00
55_Q58_K1.5351.00
134_P137_L1.5281.00
66_L120_L1.5171.00
77_T161_T1.4891.00
119_V177_L1.4821.00
140_L144_F1.4621.00
103_L205_V1.4411.00
122_I174_G1.4051.00
115_I170_V1.4041.00
19_N22_R1.3891.00
185_N188_I1.3881.00
90_V103_L1.3601.00
74_F112_G1.3561.00
143_T155_F1.3411.00
65_L177_L1.3341.00
87_A100_A1.3201.00
128_L132_L1.3161.00
87_A104_R1.3141.00
44_G47_P1.3031.00
3_L7_I1.2951.00
51_L55_Q1.2911.00
140_L143_T1.2791.00
9_Q16_P1.2701.00
102_G106_T1.2691.00
111_V166_T1.2461.00
84_I100_A1.2451.00
168_P172_A1.2281.00
82_A198_S1.2201.00
174_G193_L1.2051.00
138_L203_I1.2001.00
112_G116_A1.1981.00
39_L43_L1.1711.00
91_E99_P1.1471.00
11_F14_R1.1291.00
105_L109_I1.1261.00
161_T166_T1.1001.00
150_F209_G1.0961.00
70_F74_F1.0931.00
54_S179_S1.0801.00
122_I193_L1.0781.00
106_T208_L1.0741.00
35_T39_L1.0701.00
9_Q20_L1.0681.00
22_R25_I1.0631.00
134_P138_L1.0571.00
131_L135_G1.0501.00
160_V164_P1.0481.00
18_P21_L1.0411.00
9_Q14_R1.0341.00
141_I144_F1.0321.00
6_L20_L1.0291.00
116_A120_L1.0211.00
82_A161_T1.0191.00
51_L54_S1.0071.00
182_G185_N1.0001.00
43_L47_P1.0001.00
67_L71_L0.9951.00
62_L66_L0.9921.00
71_L75_G0.9911.00
107_V157_S0.9911.00
164_P194_I0.9901.00
16_P19_N0.9771.00
114_A200_G0.9761.00
59_K62_L0.9731.00
102_G105_L0.9701.00
120_L131_L0.9691.00
128_L195_A0.9631.00
200_G204_A0.9571.00
54_S180_A0.9571.00
66_L123_L0.9451.00
133_I137_L0.9421.00
5_V23_I0.9411.00
125_G185_N0.9401.00
89_Q92_E0.9281.00
139_V203_I0.9241.00
65_L123_L0.9091.00
56_L68_F0.9061.00
86_L157_S0.9021.00
185_N189_D0.8941.00
69_G116_A0.8941.00
198_S202_I0.8821.00
79_A165_V0.8811.00
175_L178_A0.8761.00
136_Y199_L0.8711.00
143_T206_L0.8701.00
115_I197_A0.8681.00
181_I184_R0.8651.00
82_A159_G0.8641.00
119_V174_G0.8511.00
5_V9_Q0.8471.00
159_G202_I0.8451.00
9_Q13_L0.8441.00
61_S64_L0.8371.00
62_L67_L0.8361.00
186_P189_D0.8331.00
50_E179_S0.8261.00
207_I210_L0.8251.00
77_T108_A0.8231.00
143_T151_V0.8191.00
78_I104_R0.8181.00
174_G201_P0.8171.00
146_A209_G0.8151.00
64_L67_L0.8131.00
111_V196_L0.8101.00
120_L126_I0.8081.00
82_A164_P0.8071.00
54_S58_K0.8041.00
77_T111_V0.8021.00
135_G139_V0.7951.00
159_G167_V0.7941.00
24_L27_L0.7841.00
88_K92_E0.7821.00
18_P22_R0.7721.00
84_I88_K0.7641.00
110_G200_G0.7621.00
146_A150_F0.7581.00
111_V197_A0.7561.00
59_K64_L0.7531.00
84_I104_R0.7481.00
82_A166_T0.7441.00
55_Q59_K0.7411.00
166_T198_S0.7411.00
17_I20_L0.7381.00
167_V175_L0.7371.00
110_G204_A0.7350.99
178_A184_R0.7340.99
118_G193_L0.7240.99
76_T111_V0.7240.99
63_W66_L0.7220.99
204_A207_I0.7220.99
70_F113_L0.7160.99
25_I28_V0.7150.99
12_V16_P0.7130.99
76_T112_G0.7050.99
100_A104_R0.7030.99
195_A200_G0.7020.99
159_G166_T0.6950.99
115_I173_L0.6930.99
204_A208_L0.6910.99
183_G186_P0.6900.99
5_V20_L0.6890.99
82_A160_V0.6860.99
23_I27_L0.6860.99
126_I134_P0.6860.99
129_H132_L0.6830.99
45_L48_L0.6830.99
181_I190_G0.6820.99
168_P174_G0.6820.99
63_W119_V0.6810.99
130_Y133_I0.6810.99
57_A181_I0.6700.99
156_D198_S0.6700.99
162_T202_I0.6700.99
62_L123_L0.6660.99
148_K151_V0.6660.99
158_G201_P0.6650.99
57_A180_A0.6590.99
174_G197_A0.6580.99
74_F108_A0.6560.99
3_L6_L0.6560.99
28_V32_I0.6560.99
165_V168_P0.6530.99
41_L45_L0.6490.99
153_I159_G0.6440.99
18_P28_V0.6410.99
114_A135_G0.6400.99
181_I187_L0.6390.99
91_E94_S0.6360.99
1_I9_Q0.6350.99
111_V198_S0.6340.99
53_G163_G0.6270.98
70_F109_I0.6270.98
2_V8_F0.6260.98
139_V202_I0.6260.98
48_L51_L0.6170.98
70_F77_T0.6150.98
178_A186_P0.6150.98
74_F109_I0.6110.98
181_I189_D0.6100.98
74_F78_I0.6090.98
58_K180_A0.6070.98
203_I206_L0.6060.98
8_F12_V0.6060.98
138_L141_I0.6050.98
49_G136_Y0.6030.98
145_F210_L0.6030.98
178_A194_I0.6010.98
32_I35_T0.6000.98
154_A206_L0.5980.98
48_L57_A0.5970.98
117_L135_G0.5950.98
47_P50_E0.5940.98
91_E98_I0.5930.98
42_E50_E0.5920.98
2_V7_I0.5910.98
6_L24_L0.5850.98
156_D166_T0.5800.97
82_A165_V0.5780.97
30_V34_L0.5750.97
178_A190_G0.5720.97
6_L17_I0.5720.97
2_V24_L0.5710.97
51_L59_K0.5700.97
142_L203_I0.5690.97
114_A132_L0.5680.97
97_A131_L0.5670.97
163_G171_L0.5660.97
86_L160_V0.5660.97
21_L24_L0.5630.97
114_A153_I0.5630.97
142_L210_L0.5630.97
9_Q15_L0.5620.97
13_L16_P0.5590.97
77_T162_T0.5580.97
54_S57_A0.5580.97
156_D159_G0.5570.97
184_R187_L0.5560.97
57_A177_L0.5540.97
48_L104_R0.5530.97
126_I130_Y0.5520.96
114_A196_L0.5520.96
125_G181_I0.5500.96
4_I9_Q0.5490.96
5_V10_L0.5490.96
77_T82_A0.5470.96
48_L168_P0.5460.96
17_I23_I0.5450.96
46_F175_L0.5450.96
87_A107_V0.5450.96
181_I186_P0.5440.96
122_I185_N0.5440.96
5_V15_L0.5430.96
119_V123_L0.5430.96
147_P210_L0.5380.96
175_L179_S0.5370.96
158_G196_L0.5360.96
78_I82_A0.5340.96
83_L161_T0.5340.96
198_S205_V0.5310.96
14_R17_I0.5310.96
95_G136_Y0.5310.96
5_V8_F0.5290.96
113_L200_G0.5280.95
18_P25_I0.5280.95
10_L14_R0.5240.95
37_F41_L0.5230.95
7_I12_V0.5230.95
144_F148_K0.5230.95
22_R29_L0.5220.95
38_L42_E0.5210.95
76_T164_P0.5200.95
180_A183_G0.5180.95
60_G64_L0.5150.95
202_I205_V0.5140.95
168_P173_L0.5130.95
125_G189_D0.5130.95
83_L177_L0.5130.95
15_L20_L0.5130.95
129_H188_I0.5110.95
155_F170_V0.5110.95
111_V155_F0.5100.95
15_L19_N0.5090.95
162_T174_G0.5080.94
56_L119_V0.5030.94
187_L190_G0.5030.94
139_V206_L0.5020.94
173_L194_I0.5010.94
84_I164_P0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a65A 2 0.7962 4.7 0.962 Contact Map
4xp4A 1 0.8389 3.8 0.964 Contact Map
2gfpA 2 0.6114 2.8 0.966 Contact Map
2cfqA 1 0.6967 2.2 0.968 Contact Map
4us3A 1 0.6588 1.9 0.969 Contact Map
3o7qA 1 0.872 1.7 0.97 Contact Map
4n7wA 2 0.3886 1.6 0.97 Contact Map
4f35D 2 0.7062 1.6 0.97 Contact Map
1pw4A 1 0.891 1.5 0.971 Contact Map
2kluA 1 0.1232 1.3 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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