GREMLIN Database
Coat_X - Spore Coat Protein X and V domain
PFAM: PF07552 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 58 (57)
Sequences: 549 (396)
Seq/√Len: 52.5
META: 0.463

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_S37_Q3.1631.00
23_I31_V2.9381.00
26_S29_V2.5911.00
45_L57_D1.9861.00
45_L49_L1.9050.99
19_Q33_T1.8940.99
8_L52_L1.6760.99
14_K21_I1.6440.98
33_T39_A1.6260.98
17_S35_D1.5630.98
39_A42_L1.5210.97
21_I41_N1.5200.97
20_K28_D1.4560.96
42_L55_S1.4400.96
46_L50_I1.4050.96
5_Q22_I1.2970.93
17_S50_I1.2970.93
20_K27_C1.2880.93
10_V29_V1.2300.91
9_Q15_Q1.1970.90
49_L57_D1.1400.88
15_Q19_Q1.1320.87
41_N45_L1.1140.87
29_V55_S1.0910.85
18_R37_Q1.0700.84
18_R23_I1.0560.84
23_I32_T1.0360.82
33_T36_T1.0100.81
37_Q49_L1.0000.80
43_Q47_Q0.9770.78
30_T44_A0.9660.78
50_I54_I0.9430.76
42_L54_I0.9410.76
21_I28_D0.9050.73
44_A53_V0.8980.72
18_R25_D0.8860.71
12_K23_I0.8850.71
38_A41_N0.8790.71
3_V32_T0.8630.69
38_A55_S0.8600.69
40_V44_A0.8590.69
19_Q31_V0.8420.67
24_K29_V0.8420.67
48_V52_L0.8270.66
4_T32_T0.8180.65
37_Q48_V0.8180.65
27_C58_I0.8130.65
6_E30_T0.8100.64
9_Q42_L0.7990.63
20_K52_L0.7960.63
36_T46_L0.7940.63
7_L25_D0.7840.62
19_Q37_Q0.7780.61
5_Q55_S0.7760.61
38_A48_V0.7600.59
32_T57_D0.7560.59
35_D52_L0.7490.58
4_T12_K0.7340.57
19_Q49_L0.7330.57
4_T13_T0.7240.56
7_L45_L0.7160.55
39_A51_A0.7100.54
21_I30_T0.6970.53
13_T30_T0.6920.52
3_V9_Q0.6910.52
25_D28_D0.6740.50
12_K41_N0.6720.50
34_T43_Q0.6630.49
38_A46_L0.6610.49
14_K22_I0.6600.49
28_D54_I0.6550.49
12_K21_I0.6520.48
33_T41_N0.6520.48
4_T7_L0.6380.47
10_V38_A0.6040.43
7_L54_I0.5780.41
40_V46_L0.5750.40
3_V57_D0.5750.40
2_D6_E0.5350.36
16_V29_V0.5280.36
15_Q33_T0.5270.35
12_K31_V0.5170.35
16_V30_T0.5160.34
3_V53_V0.5100.34
47_Q58_I0.5010.33
12_K22_I0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tafB 1 0.5172 0.9 0.909 Contact Map
4tq1B 1 0.3103 0.8 0.911 Contact Map
3g9xA 1 0.3103 0.8 0.912 Contact Map
2x3lA 2 0.3966 0.7 0.915 Contact Map
2k89A 1 0.6207 0.6 0.917 Contact Map
3r4vA 1 0.8966 0.6 0.917 Contact Map
1ffkF 1 0.5 0.6 0.918 Contact Map
1tafA 2 0.569 0.6 0.918 Contact Map
1vq8H 1 0.5 0.6 0.918 Contact Map
2pa2A 1 0.5345 0.6 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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