GREMLIN Database
DUF1533 - Protein of unknown function (DUF1533)
PFAM: PF07550 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 65 (59)
Sequences: 1328 (1136)
Seq/√Len: 147.9
META: 0.787

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_K60_D3.4661.00
10_S54_K2.6271.00
10_S17_A2.6121.00
14_N49_Y2.5581.00
8_I53_I2.3221.00
7_A55_A2.2701.00
43_F49_Y2.2491.00
48_D64_T2.0841.00
52_V60_D1.9631.00
14_N47_G1.9551.00
2_A6_N1.8331.00
12_T17_A1.8271.00
50_T62_T1.8211.00
24_T27_A1.7351.00
12_T54_K1.4811.00
32_S35_K1.3801.00
3_A7_A1.3681.00
25_A28_Y1.3541.00
13_V42_L1.3031.00
38_I42_L1.2801.00
12_T52_V1.2591.00
28_Y31_N1.2111.00
13_V49_Y1.2061.00
31_N34_G1.2031.00
2_A5_R1.1661.00
32_S37_T1.1451.00
5_R34_G1.1421.00
4_W61_A1.1100.99
13_V18_L1.0780.99
55_A58_Y0.9650.98
12_T15_G0.9290.98
7_A56_T0.9150.98
9_T56_T0.8890.97
13_V51_I0.8500.96
18_L49_Y0.8440.96
8_I36_I0.8070.95
18_L38_I0.7850.94
4_W11_V0.7640.93
28_Y36_I0.7330.92
24_T28_Y0.7250.92
36_I53_I0.7200.91
26_G33_A0.7120.91
30_V36_I0.7090.91
51_I65_Q0.7070.91
4_W58_Y0.6980.90
24_T44_T0.6910.90
7_A57_G0.6900.89
5_R18_L0.6870.89
25_A44_T0.6770.89
39_D42_L0.6700.88
50_T64_T0.6620.87
5_R33_A0.6570.87
46_A49_Y0.6540.87
16_T64_T0.6480.86
54_K59_K0.6340.85
15_G52_V0.6260.84
3_A6_N0.6230.84
18_L63_V0.6220.84
8_I30_V0.6220.84
27_A41_S0.6100.83
11_V61_A0.6080.83
11_V64_T0.6040.82
8_I31_N0.6000.82
32_S56_T0.5980.82
8_I12_T0.5960.81
38_I45_T0.5950.81
15_G42_L0.5950.81
61_A65_Q0.5950.81
17_A24_T0.5910.81
45_T49_Y0.5840.80
50_T60_D0.5700.78
25_A35_K0.5640.78
26_G30_V0.5590.77
37_T40_A0.5530.76
38_I41_S0.5520.76
41_S44_T0.5480.76
48_D52_V0.5450.75
11_V55_A0.5260.73
11_V36_I0.5260.73
40_A49_Y0.5190.72
41_S61_A0.5130.71
44_T49_Y0.5120.71
25_A48_D0.5090.70
27_A42_L0.5050.70
11_V54_K0.5020.69
9_T16_T0.5020.69
29_T39_D0.5010.69
29_T32_S0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o75A 2 0.9231 22.5 0.79 Contact Map
4l3aA 1 0.7692 20.3 0.794 Contact Map
1cvrA 1 0.8923 20 0.795 Contact Map
2nsmA 1 0.9385 9.8 0.821 Contact Map
3nqhA 2 0.8923 8.8 0.825 Contact Map
3kcpA 1 0.8308 8.4 0.827 Contact Map
4d6gA 1 0.9385 8 0.828 Contact Map
2vzsA 1 0 7.9 0.829 Contact Map
1uwyA 1 0.9231 7.5 0.83 Contact Map
1h8lA 1 0.9385 7.4 0.83 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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