GREMLIN Database
NOC3p - Nucleolar complex-associated protein
PFAM: PF07540 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 93 (92)
Sequences: 672 (475)
Seq/√Len: 49.6
META: 0.363

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_S76_V4.3101.00
6_I46_S3.8281.00
24_L54_I3.5031.00
63_L72_V3.3351.00
28_L47_L3.2931.00
64_T67_E2.8061.00
10_A46_S2.7821.00
47_L51_F2.5241.00
48_L93_Y2.1401.00
38_T41_K2.0391.00
31_A43_A1.8570.99
64_T72_V1.6570.98
68_K72_V1.5630.97
47_L93_Y1.5630.97
22_G26_R1.5400.97
41_K93_Y1.5390.97
12_A20_N1.5180.97
23_L77_K1.4370.95
61_R67_E1.4130.95
84_Q87_L1.3470.94
49_A53_D1.3100.93
15_E19_E1.2740.92
67_E72_V1.2640.91
13_I21_I1.2210.90
27_L58_Y1.2090.89
28_L89_G1.2040.89
10_A42_L1.1520.87
21_I24_L1.1500.87
10_A50_V1.1360.86
71_K75_E1.1170.85
33_S87_L1.1150.85
6_I43_A1.1060.85
63_L68_K1.0890.84
84_Q89_G1.0860.83
16_D78_K1.0620.82
5_E70_E1.0610.82
76_V80_R1.0590.82
14_L28_L1.0470.81
63_L87_L1.0420.81
16_D19_E1.0190.79
27_L47_L1.0150.79
65_E68_K1.0000.78
6_I27_L0.9990.78
85_A89_G0.9890.77
3_K14_L0.9820.77
73_S80_R0.9800.77
52_K93_Y0.9750.76
65_E69_A0.9660.76
18_E52_K0.9650.75
75_E79_L0.9500.74
11_S43_A0.9480.74
14_L54_I0.9410.74
72_V76_V0.9300.73
9_L27_L0.9080.71
18_E78_K0.8990.70
11_S30_L0.8940.70
41_K55_I0.8620.67
10_A28_L0.8570.66
66_K70_E0.8560.66
24_L34_K0.8530.66
43_A50_V0.8340.64
61_R68_K0.8310.64
61_R64_T0.8250.63
75_E78_K0.8170.63
35_D39_V0.8140.62
30_L48_L0.8090.62
2_A39_V0.8050.62
63_L70_E0.8000.61
66_K69_A0.7870.60
29_E34_K0.7850.60
61_R80_R0.7840.59
7_A20_N0.7790.59
28_L92_A0.7690.58
63_L80_R0.7650.58
50_V93_Y0.7620.57
12_A81_D0.7390.55
82_Y86_L0.7370.55
6_I30_L0.7360.55
5_E26_R0.7360.55
48_L52_K0.7340.54
6_I10_A0.7320.54
33_S39_V0.7290.54
31_A87_L0.7230.53
65_E80_R0.7170.53
31_A44_L0.7070.52
76_V83_E0.7040.51
64_T68_K0.7020.51
70_E84_Q0.6960.51
31_A47_L0.6770.49
32_E39_V0.6770.49
3_K45_L0.6760.49
14_L55_I0.6710.48
67_E75_E0.6600.47
21_I89_G0.6510.46
13_I23_L0.6500.46
7_A15_E0.6450.45
60_I71_K0.6380.45
7_A44_L0.6350.44
50_V88_S0.6320.44
25_K87_L0.6310.44
40_R50_V0.6270.44
35_D48_L0.6200.43
23_L44_L0.6120.42
39_V71_K0.6080.42
46_S49_A0.6050.41
72_V78_K0.6030.41
2_A14_L0.5990.41
31_A35_D0.5980.41
15_E52_K0.5970.41
45_L48_L0.5950.40
7_A49_A0.5930.40
45_L76_V0.5850.39
41_K45_L0.5800.39
48_L70_E0.5770.39
28_L91_Q0.5760.39
62_P84_Q0.5730.38
32_E69_A0.5730.38
63_L84_Q0.5660.38
27_L31_A0.5610.37
8_E12_A0.5600.37
13_I69_A0.5580.37
8_E20_N0.5520.36
28_L77_K0.5490.36
37_P89_G0.5440.36
58_Y79_L0.5370.35
22_G43_A0.5360.35
89_G92_A0.5330.35
54_I86_L0.5310.34
67_E70_E0.5300.34
27_L46_S0.5300.34
3_K74_K0.5230.34
10_A17_P0.5220.34
10_A27_L0.5190.33
8_E77_K0.5180.33
11_S14_L0.5090.32
89_G93_Y0.5080.32
64_T78_K0.5050.32
8_E40_R0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ovjA 1 0.957 20.1 0.894 Contact Map
4ev8A 1 0.5269 6 0.916 Contact Map
3u0rA 1 0.9355 5.9 0.917 Contact Map
4db6A 1 0.5484 5.6 0.918 Contact Map
5aj3J 1 0.3548 4.8 0.92 Contact Map
3o2tA 1 0.8925 4.3 0.922 Contact Map
4hxtA 2 0.6129 3.9 0.924 Contact Map
3cxlA 1 0.9355 3.4 0.926 Contact Map
2yinA 1 0.9355 3.2 0.927 Contact Map
4rv1A 1 0.6129 3.2 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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