GREMLIN Database
Big_4 - Bacterial Ig-like domain (group 4)
PFAM: PF07532 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 59 (54)
Sequences: 6087 (5007)
Seq/√Len: 681.3
META: 0.77

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_T31_E3.6091.00
24_Y30_G3.2071.00
22_V32_V2.9311.00
19_T31_E2.8111.00
21_T29_T2.3241.00
20_V34_V2.0801.00
23_T29_T1.9431.00
10_V47_P1.8531.00
19_T33_P1.8401.00
13_A44_Y1.6531.00
40_D43_D1.6471.00
9_T12_T1.4771.00
8_T12_T1.4371.00
24_Y32_V1.3411.00
16_L52_V1.2711.00
8_T14_P1.2651.00
35_T57_A1.2111.00
22_V56_V1.1971.00
34_V54_G1.1551.00
37_D55_T1.1461.00
39_I50_Y1.1451.00
37_D53_T1.1381.00
43_D46_K1.1231.00
24_Y28_S1.0761.00
32_V56_V1.0721.00
39_I44_Y1.0461.00
14_P52_V1.0401.00
44_Y50_Y1.0151.00
38_P52_V0.9821.00
20_V54_G0.9611.00
14_P44_Y0.8901.00
33_P57_A0.8881.00
32_V57_A0.8701.00
42_S45_A0.8591.00
40_D44_Y0.8271.00
43_D50_Y0.8261.00
26_D29_T0.7881.00
39_I52_V0.7861.00
25_S28_S0.7841.00
25_S30_G0.7741.00
44_Y52_V0.7541.00
16_L38_P0.7431.00
40_D52_V0.7281.00
6_V14_P0.7061.00
49_T53_T0.6951.00
42_S50_Y0.6931.00
47_P50_Y0.6871.00
10_V44_Y0.6751.00
4_V7_T0.6631.00
15_V18_A0.6611.00
24_Y52_V0.6501.00
46_K50_Y0.6461.00
27_G30_G0.6411.00
24_Y27_G0.6211.00
42_S46_K0.6171.00
11_G14_P0.6161.00
35_T55_T0.6161.00
41_A45_A0.6111.00
39_I43_D0.6011.00
27_G35_T0.5931.00
11_G45_A0.5891.00
14_P42_S0.5871.00
25_S55_T0.5831.00
23_T27_G0.5821.00
4_V47_P0.5771.00
37_D52_V0.5751.00
42_S52_V0.5741.00
38_P41_A0.5671.00
18_A33_P0.5641.00
38_P42_S0.5561.00
23_T26_D0.5491.00
10_V45_A0.5441.00
15_V41_A0.5341.00
10_V46_K0.5341.00
18_A57_A0.5321.00
23_T47_P0.5311.00
19_T22_V0.5120.99
39_I42_S0.5040.99
12_T15_V0.5020.99
16_L36_W0.5010.99
26_D30_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mh4A 1 0.9661 46.3 0.754 Contact Map
2mogA 1 0.9661 33.2 0.772 Contact Map
4f8lA 1 0.9831 18.3 0.799 Contact Map
2kpnA 1 0.9492 16.3 0.804 Contact Map
4l3aA 1 0.9322 14.8 0.807 Contact Map
4mb4A 1 0.9661 14.6 0.808 Contact Map
2l7yA 1 1 14.3 0.809 Contact Map
4urtB 1 0.8305 12.9 0.813 Contact Map
4n68A 1 0.6102 12.8 0.813 Contact Map
3p4lA 1 0.8305 12.1 0.814 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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