GREMLIN Database
PRE_C2HC - Associated with zinc fingers
PFAM: PF07530 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (65)
Sequences: 912 (585)
Seq/√Len: 72.5
META: 0.83

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_E10_E3.5181.00
20_N33_F3.2791.00
16_R38_E2.8461.00
51_A56_K2.6671.00
5_K9_E2.4691.00
45_D48_K2.2241.00
42_N45_D1.9671.00
36_D39_P1.8301.00
7_E11_L1.6901.00
21_I34_F1.6381.00
49_I57_I1.5040.99
36_D62_P1.4850.99
49_I59_V1.4840.99
47_Y61_P1.4530.99
2_E6_Q1.4510.99
21_I31_P1.3000.97
13_H43_N1.2920.97
37_L43_N1.2790.97
14_K35_V1.2370.97
6_Q9_E1.2240.96
19_T53_L1.2140.96
19_T22_K1.1950.96
39_P62_P1.1500.95
2_E5_K1.1490.95
6_Q10_E1.1360.94
50_T56_K1.0930.93
30_L55_T1.0930.93
9_E15_V1.0540.92
4_I8_L1.0540.92
16_R39_P1.0490.92
55_T64_K1.0450.91
14_K38_E1.0120.90
50_T58_K1.0090.90
35_V59_V1.0030.90
20_N36_D1.0010.90
31_P65_K0.9890.89
18_V23_H0.9820.89
3_D47_Y0.9630.88
51_A55_T0.9450.87
25_V50_T0.9450.87
47_Y53_L0.9430.87
13_H42_N0.9330.86
17_N36_D0.9040.84
59_V64_K0.8960.84
22_K37_L0.8850.83
34_F39_P0.8840.83
23_H26_T0.8690.82
44_K48_K0.8480.80
3_D6_Q0.8270.79
31_P55_T0.8110.77
22_K27_K0.7990.76
7_E53_L0.7760.74
19_T28_E0.7740.74
34_F55_T0.7690.73
2_E25_V0.7690.73
11_L52_L0.7500.71
6_Q32_L0.7340.70
13_H49_I0.7330.70
28_E51_A0.7310.70
13_H40_A0.7290.69
23_H30_L0.7280.69
17_N34_F0.7240.69
13_H45_D0.7220.69
31_P54_N0.7110.67
7_E52_L0.6940.66
41_E49_I0.6860.65
25_V52_L0.6830.64
31_P56_K0.6810.64
8_L15_V0.6800.64
56_K64_K0.6780.64
28_E32_L0.6690.63
11_L26_T0.6480.60
9_E50_T0.6210.57
28_E31_P0.6090.56
12_G17_N0.6080.55
61_P64_K0.5960.54
23_H55_T0.5910.53
31_P66_K0.5890.53
50_T57_I0.5860.53
27_K62_P0.5850.53
17_N20_N0.5820.52
23_H28_E0.5720.51
2_E41_E0.5660.50
58_K64_K0.5610.50
32_L58_K0.5510.48
48_K65_K0.5490.48
26_T29_P0.5410.47
21_I32_L0.5400.47
34_F43_N0.5390.47
5_K56_K0.5330.46
23_H29_P0.5300.46
34_F52_L0.5250.45
11_L22_K0.5130.44
22_K28_E0.5070.43
7_E46_I0.5070.43
34_F62_P0.5050.43
12_G43_N0.5050.43
9_E48_K0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q2sC 1 1 62.7 0.806 Contact Map
1x4bA 1 0.9853 57 0.813 Contact Map
3n9uC 1 1 55.2 0.815 Contact Map
2dh8A 1 0.9853 53.9 0.817 Contact Map
1p27B 1 0.9853 53.7 0.817 Contact Map
2cqgA 1 0.9853 52.9 0.818 Contact Map
2cqdA 1 0.9853 52.8 0.818 Contact Map
1x5uA 1 0.9853 52.2 0.819 Contact Map
2lxiA 1 1 51.6 0.819 Contact Map
3pgwS 1 0.9559 51.6 0.819 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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