GREMLIN Database
POX - Associated with HOX
PFAM: PF07526 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 136 (135)
Sequences: 763 (595)
Seq/√Len: 51.2
META: 0.018

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_L134_A2.9861.00
27_K30_S2.5551.00
37_K41_G2.4651.00
106_A132_R2.4631.00
103_S107_V2.3341.00
91_K108_A2.3321.00
53_S57_S2.2111.00
21_V84_D2.1811.00
36_K39_S2.1211.00
78_K85_E2.1031.00
22_G132_R2.0731.00
126_R132_R2.0161.00
75_K124_I2.0001.00
118_A122_K1.8740.99
26_K29_S1.8630.99
82_M97_M1.7870.99
95_H99_A1.7140.99
45_S48_G1.7060.99
41_G46_S1.7050.99
41_G44_E1.6300.98
25_G28_S1.6290.98
116_Y128_F1.6120.98
28_S33_K1.5460.97
29_S32_S1.5410.97
36_K40_S1.5390.97
84_D115_P1.5300.97
16_D22_G1.5110.97
82_M85_E1.4960.97
27_K31_A1.4680.96
51_S54_S1.4600.96
43_S46_S1.4470.96
27_K34_K1.4000.95
38_K42_S1.3870.95
93_Y128_F1.3710.95
34_K41_G1.3670.95
98_Q105_E1.3560.94
96_Q113_A1.3480.94
87_D132_R1.3380.94
7_Y40_S1.3360.94
43_S47_G1.3180.93
3_R92_Q1.2940.93
108_A120_A1.2900.93
3_R76_K1.2760.92
35_S38_K1.2650.92
39_S42_S1.2580.92
30_S33_K1.2530.92
77_A100_V1.2370.91
11_A17_E1.2170.90
83_L111_G1.2010.90
8_L121_L1.1910.89
3_R107_V1.1860.89
82_M130_C1.1750.89
109_G116_Y1.1650.88
57_S60_S1.1450.87
76_K107_V1.1360.87
4_N118_A1.1270.87
46_S53_S1.1080.86
27_K35_S1.1040.85
41_G45_S1.1000.85
31_A37_K1.0970.85
2_L88_R1.0970.85
54_S57_S1.0820.84
81_S103_S1.0740.84
69_R117_T1.0690.84
33_K40_S1.0560.83
8_L108_A1.0520.83
40_S44_E1.0490.82
105_E126_R1.0460.82
3_R12_Q1.0450.82
88_R127_H1.0380.82
25_G29_S1.0360.82
20_S95_H1.0250.81
22_G124_I1.0230.81
89_R105_E1.0130.80
33_K36_K1.0090.80
106_A112_A1.0020.79
34_K38_K1.0000.79
38_K41_G0.9920.79
44_E47_G0.9910.79
81_S98_Q0.9910.79
16_D98_Q0.9860.78
72_L133_D0.9700.77
53_S56_S0.9610.76
7_Y95_H0.9470.75
43_S48_G0.9460.75
52_S58_S0.9440.75
66_T69_R0.9350.74
68_E115_P0.9330.74
112_A116_Y0.9250.74
106_A114_K0.9250.74
80_L105_E0.9170.73
72_L117_T0.9140.73
66_T112_A0.9090.72
76_K106_A0.8940.71
77_A106_A0.8860.70
91_K110_L0.8810.70
54_S58_S0.8770.70
32_S47_G0.8760.69
35_S42_S0.8750.69
24_K28_S0.8730.69
51_S55_S0.8710.69
30_S34_K0.8670.69
40_S43_S0.8660.69
3_R106_A0.8570.68
26_K30_S0.8560.68
43_S51_S0.8550.68
109_G113_A0.8540.67
37_K44_E0.8500.67
52_S56_S0.8500.67
26_K44_E0.8470.67
22_G123_T0.8450.67
88_R130_C0.8380.66
109_G128_F0.8290.65
39_S45_S0.8210.64
37_K43_S0.8190.64
85_E128_F0.8170.64
98_Q115_P0.8150.64
7_Y111_G0.8130.64
34_K39_S0.8120.64
18_F92_Q0.8000.62
93_Y116_Y0.8000.62
77_A81_S0.7960.62
83_L123_T0.7960.62
125_S129_R0.7880.61
80_L85_E0.7800.60
6_K99_A0.7800.60
27_K33_K0.7720.60
45_S49_D0.7670.59
4_N119_L0.7670.59
29_S35_S0.7670.59
22_G80_L0.7670.59
18_F95_H0.7620.59
74_R124_I0.7580.58
9_K134_A0.7440.57
25_G32_S0.7340.56
87_D133_D0.7280.55
42_S53_S0.7120.54
83_L119_L0.7110.53
10_P127_H0.7060.53
31_A36_K0.7030.53
37_K42_S0.7010.52
124_I127_H0.6990.52
37_K56_S0.6900.51
76_K81_S0.6790.50
47_G53_S0.6720.49
31_A47_G0.6700.49
74_R88_R0.6690.49
28_S48_G0.6680.49
42_S50_G0.6640.49
31_A46_S0.6560.48
18_F75_K0.6450.47
2_L5_S0.6420.46
42_S60_S0.6290.45
48_G51_S0.6270.45
12_Q78_K0.6250.45
26_K40_S0.6240.44
33_K39_S0.6230.44
29_S43_S0.6160.44
76_K129_R0.6150.43
4_N73_Q0.6110.43
46_S49_D0.6110.43
88_R94_Y0.6100.43
37_K45_S0.6100.43
35_S46_S0.6090.43
26_K31_A0.6010.42
31_A35_S0.5990.42
108_A113_A0.5930.41
48_G61_S0.5890.41
19_C74_R0.5880.41
34_K40_S0.5870.41
36_K42_S0.5830.40
70_Q114_K0.5740.39
13_E97_M0.5730.39
46_S51_S0.5590.38
52_S55_S0.5580.38
101_V122_K0.5550.37
74_R87_D0.5540.37
37_K60_S0.5530.37
93_Y127_H0.5510.37
56_S59_K0.5500.37
63_E66_T0.5470.37
128_F134_A0.5420.36
27_K32_S0.5410.36
48_G53_S0.5400.36
4_N105_E0.5280.35
43_S49_D0.5270.35
55_S58_S0.5270.35
10_P105_E0.5240.35
10_P85_E0.5240.35
93_Y134_A0.5210.34
85_E93_Y0.5210.34
105_E115_P0.5180.34
100_V131_L0.5160.34
126_R133_D0.5150.34
83_L87_D0.5120.33
29_S34_K0.5090.33
105_E128_F0.5080.33
12_Q85_E0.5070.33
36_K48_G0.5070.33
2_L22_G0.5060.33
107_V115_P0.5010.32
20_S119_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ymyA 2 0.3015 10 0.945 Contact Map
1x8yA 2 0.4044 9.6 0.945 Contact Map
1we3A 5 0.9926 6.5 0.949 Contact Map
1p5sA 1 0.2941 6.5 0.949 Contact Map
2lyhA 1 0.3088 5.7 0.951 Contact Map
3hugA 3 0.5147 5.7 0.951 Contact Map
4aflA 2 0.5735 5 0.952 Contact Map
2noxA 6 0.6324 4.6 0.953 Contact Map
1iokA 5 0.9118 4.3 0.953 Contact Map
2qwoB 1 0.3824 4.2 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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