GREMLIN Database
DUF1525 - Protein of unknown function (DUF1525)
PFAM: PF07511 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 113 (110)
Sequences: 831 (593)
Seq/√Len: 56.5
META: 0.65

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_D11_H4.0821.00
27_P69_Y3.9871.00
5_V13_V3.7141.00
39_P48_I3.5071.00
46_K50_Q3.4171.00
39_P45_A3.1931.00
97_V102_R2.6101.00
41_D44_Q2.2731.00
88_F107_Y2.0931.00
38_L45_A2.0181.00
86_V103_A1.9851.00
27_P72_V1.9491.00
35_S38_L1.8540.99
23_E29_R1.8530.99
7_T12_P1.6930.99
57_G61_L1.6000.98
92_Y107_Y1.5740.98
6_F22_Y1.5650.98
37_G52_R1.5630.98
22_Y71_G1.5610.98
85_A95_Y1.4960.98
93_V96_G1.4820.97
7_T11_H1.4370.97
108_E112_R1.4340.97
16_P19_V1.4290.97
43_E46_K1.4200.97
92_Y110_W1.3920.96
88_F92_Y1.3800.96
57_G64_R1.3080.95
78_L87_V1.2960.95
106_R110_W1.2730.94
5_V100_V1.2300.93
85_A93_V1.2260.93
78_L107_Y1.1830.91
91_R101_A1.1820.91
49_A53_L1.1820.91
48_I52_R1.1800.91
102_R105_A1.1530.90
73_A77_Q1.1440.90
60_A63_Q1.1280.89
47_A63_Q1.0990.88
6_F10_A1.0950.88
80_I83_Y1.0910.88
54_Q80_I1.0750.87
56_P72_V1.0670.86
4_E78_L1.0610.86
49_A52_R1.0580.86
50_Q54_Q1.0430.85
38_L41_D1.0340.85
77_Q81_D1.0260.84
88_F97_V1.0220.84
4_E90_G0.9940.82
6_F87_V0.9580.80
56_P82_K0.9500.79
2_E90_G0.9470.79
27_P31_E0.9470.79
74_D78_L0.9420.79
82_K103_A0.9410.79
31_E35_S0.9410.79
75_A85_A0.9400.78
64_R79_G0.9400.78
3_V6_F0.9360.78
48_I51_Q0.9010.75
105_A108_E0.8820.74
81_D97_V0.8750.73
101_A108_E0.8690.73
94_V106_R0.8660.73
35_S52_R0.8510.71
9_S26_A0.8470.71
15_A19_V0.8450.71
33_E48_I0.8310.69
105_A111_R0.8300.69
101_A104_L0.8260.69
65_L98_T0.8230.69
35_S45_A0.8130.68
24_L72_V0.8120.68
88_F110_W0.8100.67
83_Y88_F0.8070.67
42_P54_Q0.8030.67
4_E87_V0.7940.66
33_E64_R0.7860.65
20_R65_L0.7790.64
46_K86_V0.7790.64
102_R109_Q0.7750.64
19_V60_A0.7670.63
82_K100_V0.7590.62
22_Y76_W0.7510.62
5_V16_P0.7460.61
73_A76_W0.7450.61
106_R109_Q0.7410.60
45_A82_K0.7300.59
76_W79_G0.7270.59
47_A67_Q0.7260.59
102_R106_R0.7240.59
38_L42_P0.7210.58
30_L39_P0.7190.58
14_T33_E0.7160.58
9_S37_G0.7100.57
43_E71_G0.7050.57
28_E51_Q0.7020.56
47_A51_Q0.6940.55
10_A14_T0.6900.55
77_Q90_G0.6880.55
104_L108_E0.6830.54
25_D86_V0.6830.54
86_V98_T0.6820.54
55_S61_L0.6820.54
32_A89_D0.6800.54
8_D83_Y0.6770.54
45_A49_A0.6730.53
94_V103_A0.6720.53
2_E6_F0.6720.53
39_P97_V0.6720.53
4_E35_S0.6650.52
4_E20_R0.6610.52
44_Q48_I0.6540.51
86_V94_V0.6500.51
29_R32_A0.6490.51
40_A101_A0.6440.50
30_L60_A0.6400.50
74_D77_Q0.6390.50
49_A88_F0.6380.49
67_Q77_Q0.6370.49
41_D45_A0.6360.49
14_T19_V0.6350.49
39_P100_V0.6330.49
89_D107_Y0.6310.49
17_A100_V0.6290.48
63_Q67_Q0.6210.48
30_L65_L0.6180.47
25_D72_V0.6080.46
38_L52_R0.6040.46
56_P59_A0.5980.45
31_E74_D0.5960.45
40_A43_E0.5940.45
107_Y110_W0.5940.45
52_R90_G0.5880.44
15_A63_Q0.5830.43
75_A94_V0.5810.43
10_A17_A0.5730.42
47_A60_A0.5640.41
4_E11_H0.5630.41
14_T104_L0.5600.41
55_S94_V0.5590.41
12_P24_L0.5580.41
53_L56_P0.5570.41
67_Q70_Q0.5530.40
6_F20_R0.5490.40
34_L49_A0.5360.38
50_Q69_Y0.5360.38
42_P45_A0.5350.38
63_Q66_A0.5350.38
70_Q74_D0.5340.38
62_Q112_R0.5290.38
88_F94_V0.5280.38
68_A72_V0.5270.38
23_E73_A0.5260.37
88_F104_L0.5240.37
29_R40_A0.5180.37
20_R24_L0.5130.36
56_P61_L0.5030.35
70_Q77_Q0.5010.35
10_A15_A0.5010.35
70_Q73_A0.5000.35
96_G99_D0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ktbA 5 0.8496 85.8 0.855 Contact Map
3kgkA 2 0.7965 84.3 0.858 Contact Map
3gl5A 2 0.9027 81.5 0.862 Contact Map
3c7mA 1 0.9115 75 0.87 Contact Map
3gv1A 2 0.9912 73.2 0.872 Contact Map
4p3yB 1 0.9115 72.7 0.872 Contact Map
3ghaA 1 0.9292 71.7 0.873 Contact Map
1un2A 1 0.708 71.3 0.874 Contact Map
4od7A 1 0.9469 71.2 0.874 Contact Map
2znmA 3 0.9204 71.2 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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