GREMLIN Database
DUF1524 - Protein of unknown function (DUF1524)
PFAM: PF07510 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 139 (135)
Sequences: 19628 (15930)
Seq/√Len: 1371.0
META: 0.831

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_T128_E4.3701.00
80_R133_Q3.2121.00
98_K102_E2.7411.00
121_K128_E2.6131.00
77_Y130_E2.1931.00
88_S91_L2.1421.00
87_L95_L1.9991.00
99_P102_E1.9871.00
117_E135_A1.9801.00
100_F104_K1.9631.00
89_G93_S1.9061.00
106_G109_K1.8471.00
70_D73_E1.8231.00
77_Y80_R1.7801.00
85_T115_N1.7681.00
9_R13_T1.7001.00
113_Y116_R1.6771.00
126_E130_E1.6321.00
74_R78_L1.6061.00
73_E126_E1.5911.00
25_R29_E1.5871.00
123_E128_E1.5591.00
82_G129_I1.5581.00
12_K134_E1.4821.00
3_R6_E1.4791.00
57_Q78_L1.4711.00
8_R12_K1.4611.00
58_N97_N1.4591.00
5_D9_R1.4521.00
55_L74_R1.4171.00
8_R138_E1.3971.00
59_P63_W1.3921.00
77_Y126_E1.3921.00
133_Q137_A1.3811.00
53_H92_N1.3691.00
11_L137_A1.3681.00
52_E103_K1.3681.00
93_S96_S1.3571.00
79_H84_L1.3531.00
127_E131_A1.3511.00
57_Q79_H1.3141.00
33_E37_R1.2631.00
112_L115_N1.2621.00
59_P74_R1.2581.00
41_E44_F1.2551.00
95_L106_G1.2541.00
85_T114_L1.2281.00
55_L124_W1.2151.00
55_L129_I1.2121.00
26_Y31_R1.2021.00
59_P97_N1.1991.00
131_A135_A1.1981.00
115_N119_A1.1601.00
115_N118_L1.1551.00
51_I84_L1.1461.00
121_K131_A1.1291.00
80_R130_E1.1251.00
50_T93_S1.1131.00
15_D18_N1.1051.00
10_A13_T1.0881.00
72_E76_E1.0831.00
7_F11_L1.0711.00
128_E131_A1.0631.00
32_L36_L1.0561.00
87_L91_L1.0521.00
52_E95_L1.0381.00
40_E43_D1.0361.00
42_I45_D1.0321.00
24_L51_I1.0291.00
69_W73_E1.0251.00
117_E121_K1.0141.00
100_F121_K1.0041.00
46_P49_L1.0041.00
55_L59_P1.0041.00
114_L136_L1.0001.00
130_E134_E0.9951.00
34_N37_R0.9921.00
54_I100_F0.9891.00
105_K108_K0.9831.00
47_G50_T0.9741.00
91_L103_K0.9691.00
59_P62_E0.9641.00
46_P50_T0.9531.00
102_E105_K0.9481.00
6_E9_R0.9471.00
24_L28_L0.9461.00
69_W72_E0.9361.00
77_Y83_N0.9191.00
50_T89_G0.9011.00
132_R136_L0.9011.00
116_R119_A0.8991.00
9_R12_K0.8961.00
113_Y117_E0.8891.00
108_K119_A0.8851.00
5_D8_R0.8851.00
11_L81_L0.8791.00
85_T118_L0.8621.00
23_R26_Y0.8621.00
67_G70_D0.8571.00
114_L117_E0.8461.00
114_L118_L0.8451.00
71_E75_E0.8441.00
110_S115_N0.8341.00
62_E99_P0.8321.00
73_E77_Y0.8271.00
6_E10_A0.8221.00
131_A134_E0.8211.00
54_I85_T0.8151.00
17_Y79_H0.8101.00
88_S110_S0.8081.00
31_R34_N0.8071.00
37_R111_C0.8041.00
33_E36_L0.7951.00
82_G119_A0.7931.00
66_L69_W0.7921.00
36_L117_E0.7911.00
104_K122_D0.7911.00
82_G133_Q0.7881.00
19_G22_R0.7861.00
45_D49_L0.7831.00
65_G69_W0.7781.00
42_I46_P0.7761.00
25_R28_L0.7651.00
40_E44_F0.7631.00
112_L116_R0.7631.00
130_E133_Q0.7561.00
66_L70_D0.7561.00
23_R27_I0.7541.00
16_L19_G0.7521.00
101_L104_K0.7521.00
83_N129_I0.7451.00
90_S93_S0.7421.00
73_E76_E0.7371.00
8_R137_A0.7351.00
38_T91_L0.7341.00
41_E45_D0.7341.00
94_S106_G0.7311.00
110_S113_Y0.7271.00
12_K15_D0.7211.00
29_E34_N0.7171.00
20_R23_R0.7171.00
127_E130_E0.7131.00
111_C115_N0.7071.00
111_C116_R0.7051.00
14_K17_Y0.6941.00
118_L121_K0.6771.00
36_L39_G0.6741.00
64_E67_G0.6631.00
82_G123_E0.6611.00
101_L105_K0.6571.00
100_F103_K0.6571.00
77_Y129_I0.6561.00
26_Y29_E0.6561.00
65_G123_E0.6561.00
40_E45_D0.6561.00
111_C114_L0.6521.00
45_D48_K0.6491.00
14_K19_G0.6471.00
110_S114_L0.6461.00
34_N38_T0.6421.00
43_D46_P0.6411.00
75_E78_L0.6361.00
95_L103_K0.6341.00
23_R29_E0.6321.00
102_E106_G0.6291.00
18_N21_R0.6191.00
95_L107_Y0.6181.00
15_D20_R0.6131.00
134_E138_E0.6131.00
16_L21_R0.6101.00
8_R134_E0.6091.00
58_N62_E0.6071.00
81_L133_Q0.6051.00
95_L99_P0.6001.00
64_E68_E0.5971.00
18_N22_R0.5871.00
111_C117_E0.5811.00
129_I133_Q0.5781.00
135_A138_E0.5711.00
71_E74_R0.5651.00
76_E126_E0.5641.00
17_Y20_R0.5621.00
98_K106_G0.5551.00
56_P83_N0.5531.00
91_L95_L0.5471.00
74_R77_Y0.5471.00
70_D74_R0.5431.00
11_L14_K0.5431.00
54_I107_Y0.5421.00
12_K137_A0.5391.00
113_Y118_L0.5371.00
28_L86_L0.5351.00
44_F48_K0.5341.00
16_L20_R0.5261.00
24_L27_I0.5201.00
49_L112_L0.5181.00
61_W74_R0.5131.00
121_K135_A0.5081.00
4_D8_R0.5051.00
37_R41_E0.5031.00
55_L78_L0.5001.00
16_L81_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4un4B 1 0.7914 49 0.859 Contact Map
4ogeA 1 0.8633 39.6 0.867 Contact Map
4h9dA 3 0.6115 22.6 0.882 Contact Map
4uhqA 1 0.6331 13.3 0.894 Contact Map
7ceiB 1 0.5755 12.9 0.894 Contact Map
3m7kA 2 0.7986 5.5 0.91 Contact Map
1fr2B 1 0.554 5.3 0.911 Contact Map
3zfkA 1 0.5468 5.3 0.911 Contact Map
4qkoB 2 0.5683 3.1 0.921 Contact Map
2pu3A 1 0.9712 2.8 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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