GREMLIN Database
DUF1523 - Protein of unknown function (DUF1523)
PFAM: PF07509 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 176 (173)
Sequences: 908 (660)
Seq/√Len: 50.2
META: 0.749

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_F157_F5.7701.00
27_H149_L4.5921.00
100_N128_E3.7581.00
150_I155_I3.0331.00
142_V147_V2.9491.00
169_W173_R2.9421.00
166_L170_R2.7101.00
26_Q122_H2.4501.00
158_L162_A2.4241.00
108_L118_V2.3891.00
119_A142_V2.3581.00
116_Q141_P2.3571.00
171_R174_R2.3271.00
119_A140_K2.2731.00
167_A171_R2.2211.00
34_G106_Q2.1251.00
70_N106_Q2.0981.00
71_T79_M1.9450.99
28_D122_H1.9330.99
10_L14_L1.9220.99
166_L171_R1.9130.99
3_Y6_W1.8150.99
143_D147_V1.7750.99
101_L136_A1.7470.99
119_A149_L1.7390.99
13_W17_A1.6550.98
19_F23_T1.6420.98
73_R79_M1.6330.98
163_A170_R1.6260.98
113_A116_Q1.6080.98
167_A170_R1.5850.98
170_R173_R1.5850.98
169_W172_W1.5650.97
28_D81_Y1.5520.97
27_H119_A1.5450.97
41_D63_T1.5250.97
72_V78_V1.5230.97
72_V107_D1.5160.97
33_T103_A1.5130.97
111_T115_P1.4880.96
110_S115_P1.4520.96
121_T137_V1.4510.96
49_W66_V1.4400.96
30_V120_V1.4350.96
67_R98_S1.4320.96
67_R70_N1.4270.95
121_T140_K1.4240.95
163_A167_A1.4100.95
70_N103_A1.3550.94
9_R13_W1.3480.94
163_A166_L1.3460.94
38_K67_R1.3270.93
21_H26_Q1.3000.93
119_A147_V1.2850.92
38_K68_F1.2810.92
80_V100_N1.2700.92
172_W175_F1.2550.91
151_P154_N1.2540.91
37_V70_N1.2480.91
38_K70_N1.2350.91
33_T78_V1.2230.90
167_A174_R1.2190.90
49_W68_F1.2150.90
170_R174_R1.2090.90
3_Y7_T1.2010.89
34_G70_N1.1830.89
31_R110_S1.1790.88
34_G109_A1.1770.88
36_E70_N1.1690.88
172_W176_R1.1680.88
42_F46_S1.1420.87
112_K116_Q1.1330.86
160_L164_L1.1270.86
80_V103_A1.1250.86
118_V139_I1.1110.85
26_Q79_M1.1040.85
23_T90_W1.0870.84
39_R63_T1.0830.84
20_L161_L1.0700.83
119_A144_G1.0600.82
40_V131_S1.0490.82
154_N157_F1.0440.81
38_K66_V1.0360.81
168_I172_W1.0310.81
167_A173_R1.0180.80
46_S49_W1.0030.79
86_T91_P0.9990.78
120_V139_I0.9970.78
33_T133_F0.9960.78
67_R99_S0.9950.78
165_L169_W0.9860.77
89_G96_F0.9850.77
127_I130_L0.9820.77
37_V67_R0.9770.77
29_I119_A0.9500.75
38_K49_W0.9370.74
163_A171_R0.9260.73
121_T153_F0.9200.72
40_V66_V0.9190.72
42_F47_I0.9190.72
34_G37_V0.8950.70
6_W10_L0.8820.69
72_V76_G0.8670.68
121_T138_S0.8610.67
156_V159_T0.8570.67
127_I132_I0.8520.66
67_R133_F0.8520.66
40_V67_R0.8420.66
36_E98_S0.8380.65
44_G49_W0.8330.65
21_H122_H0.8280.64
73_R81_Y0.8260.64
36_E109_A0.8230.64
12_L81_Y0.8170.63
108_L116_Q0.8120.63
146_D149_L0.8110.63
106_Q109_A0.8090.62
45_N50_A0.8070.62
57_G60_T0.8050.62
32_I71_T0.8040.62
40_V68_F0.7940.61
34_G38_K0.7940.61
47_I51_Q0.7860.60
66_V133_F0.7860.60
7_T11_L0.7800.60
2_R176_R0.7790.60
31_R107_D0.7780.59
40_V63_T0.7710.59
19_F92_P0.7700.59
69_I136_A0.7700.59
45_N67_R0.7630.58
23_T92_P0.7600.58
46_S50_A0.7530.57
147_V151_P0.7520.57
9_R169_W0.7450.56
43_G46_S0.7450.56
157_F160_L0.7390.55
27_H121_T0.7350.55
70_N98_S0.7320.55
57_G63_T0.7280.54
37_V96_F0.7250.54
99_S131_S0.7140.53
17_A20_L0.7110.53
165_L170_R0.7090.52
27_H154_N0.7090.52
42_F67_R0.7060.52
159_T166_L0.7020.52
64_R84_E0.7010.52
43_G66_V0.7010.52
109_A112_K0.7000.52
166_L169_W0.6950.51
107_D112_K0.6900.50
78_V104_E0.6870.50
111_T114_A0.6840.50
7_T10_L0.6810.50
37_V68_F0.6780.49
99_S115_P0.6750.49
119_A143_D0.6730.49
98_S107_D0.6720.49
78_V100_N0.6700.48
39_R89_G0.6670.48
81_Y122_H0.6660.48
30_V81_Y0.6600.47
9_R12_L0.6590.47
24_L30_V0.6550.47
8_F14_L0.6550.47
37_V41_D0.6550.47
159_T176_R0.6520.47
97_D100_N0.6490.46
40_V44_G0.6480.46
102_Q106_Q0.6420.46
4_V7_T0.6380.45
167_A172_W0.6380.45
38_K133_F0.6370.45
29_I149_L0.6350.45
20_L158_L0.6350.45
33_T38_K0.6270.44
42_F45_N0.6260.44
162_A170_R0.6250.44
161_L164_L0.6210.43
169_W176_R0.6160.43
16_V120_V0.6150.43
45_N49_W0.6150.43
35_T39_R0.6130.43
29_I147_V0.6090.42
100_N103_A0.6090.42
137_V154_N0.6080.42
8_F81_Y0.6060.42
40_V58_T0.6050.42
2_R5_K0.6040.42
51_Q59_A0.6030.42
28_D136_A0.6020.42
162_A165_L0.6010.41
149_L152_W0.6010.41
169_W174_R0.6000.41
76_G118_V0.6000.41
166_L174_R0.5990.41
20_L24_L0.5990.41
49_W89_G0.5940.41
166_L173_R0.5900.40
111_T116_Q0.5880.40
48_F152_W0.5870.40
149_L155_I0.5850.40
164_L168_I0.5830.40
33_T72_V0.5770.39
11_L77_K0.5750.39
67_R102_Q0.5750.39
78_V137_V0.5740.39
38_K57_G0.5740.39
52_P60_T0.5730.39
143_D148_R0.5730.39
104_E133_F0.5680.38
43_G68_F0.5670.38
142_V146_D0.5640.38
20_L168_I0.5620.38
147_V150_I0.5600.37
105_A139_I0.5570.37
93_Y137_V0.5550.37
45_N51_Q0.5540.37
63_T100_N0.5520.37
24_L90_W0.5510.37
21_H125_W0.5490.36
47_I77_K0.5460.36
154_N159_T0.5460.36
46_S60_T0.5460.36
8_F16_V0.5450.36
40_V49_W0.5440.36
70_N102_Q0.5440.36
162_A169_W0.5420.36
68_F133_F0.5410.36
51_Q57_G0.5390.35
30_V118_V0.5360.35
40_V43_G0.5360.35
91_P96_F0.5350.35
37_V43_G0.5340.35
51_Q60_T0.5310.35
29_I98_S0.5300.35
43_G67_R0.5270.34
66_V103_A0.5250.34
140_K147_V0.5240.34
156_V160_L0.5240.34
49_W133_F0.5220.34
24_L27_H0.5210.34
36_E67_R0.5200.34
109_A115_P0.5170.33
150_I163_A0.5130.33
28_D64_R0.5120.33
15_L139_I0.5120.33
96_F100_N0.5110.33
37_V40_V0.5110.33
38_K99_S0.5110.33
50_A100_N0.5100.33
37_V98_S0.5090.33
20_L148_R0.5080.33
44_G66_V0.5080.33
53_D63_T0.5070.32
100_N104_E0.5060.32
38_K43_G0.5030.32
4_V11_L0.5000.32
38_K46_S0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kncB 1 0.2216 6.8 0.968 Contact Map
1pfiA 7 0.1591 6.5 0.968 Contact Map
1m56D 1 0.1307 4 0.971 Contact Map
4m64A 1 0.2159 3.2 0.972 Contact Map
1t0fC 1 0.2727 3.2 0.972 Contact Map
4ymkA 1 0.4489 3.2 0.973 Contact Map
4tphA 2 0.1705 3.1 0.973 Contact Map
1qleD 1 0.1307 2.9 0.973 Contact Map
2ww9C 1 0.1136 2.7 0.973 Contact Map
2kncA 1 0.2045 2.4 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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