GREMLIN Database
PPI_Ypi1 - Protein phosphatase inhibitor
PFAM: PF07491 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (53)
Sequences: 582 (378)
Seq/√Len: 52.0
META: 0.321

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_Y46_P6.8441.00
23_T26_V3.8841.00
39_I44_H2.9681.00
28_D32_M2.5591.00
52_S55_E2.4111.00
36_K39_I1.9240.99
33_G36_K1.8350.99
54_S57_S1.7290.99
36_K53_S1.5340.97
13_K16_P1.3410.94
39_I58_S1.3250.94
52_S56_S1.3040.93
47_R51_E1.2930.93
24_E35_K1.2430.92
28_D31_G1.2290.91
22_W47_R1.2170.91
47_R50_D1.1470.88
29_N32_M1.0600.83
35_K38_K1.0600.83
24_E39_I1.0400.82
27_V35_K1.0140.81
27_V51_E0.9790.78
44_H58_S0.9620.77
47_R54_S0.9540.76
43_Y48_A0.9380.75
13_K19_R0.9270.74
38_K55_E0.9220.74
38_K57_S0.8750.70
3_R47_R0.8550.68
29_N34_K0.8460.67
15_R18_R0.8310.66
26_V44_H0.8250.65
29_N42_I0.8160.65
3_R19_R0.7840.61
45_K48_A0.7820.61
29_N36_K0.7820.61
16_P34_K0.7730.60
12_A37_S0.7560.59
20_V24_E0.7460.58
26_V50_D0.7450.57
45_K52_S0.7330.56
39_I59_S0.7190.55
38_K49_F0.7160.54
39_I43_Y0.7100.54
39_I42_I0.7100.54
31_G34_K0.7060.53
6_G39_I0.6900.52
22_W57_S0.6780.51
26_V47_R0.6710.50
3_R15_R0.6620.49
31_G48_A0.6500.48
49_F53_S0.6500.48
36_K46_P0.6390.46
12_A58_S0.6390.46
45_K54_S0.6340.46
21_Q48_A0.6150.44
37_S47_R0.6130.44
18_R24_E0.5920.42
45_K49_F0.5840.41
42_I58_S0.5830.41
6_G43_Y0.5800.40
49_F52_S0.5750.40
3_R6_G0.5710.40
14_P45_K0.5680.39
41_C45_K0.5630.39
14_P24_E0.5630.39
13_K20_V0.5480.37
37_S45_K0.5460.37
15_R19_R0.5430.37
41_C44_H0.5400.36
17_R21_Q0.5360.36
54_S59_S0.5240.35
18_R37_S0.5240.35
16_P56_S0.5240.35
12_A20_V0.5180.34
12_A23_T0.5130.34
44_H55_E0.5060.33
16_P31_G0.5040.33
12_A17_R0.5040.33
35_K39_I0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bovA 1 0.15 4.8 0.91 Contact Map
1se9A 1 0.1833 3.5 0.916 Contact Map
4m6tA 5 0.6167 3.2 0.918 Contact Map
2bcgY 1 0.4833 2.9 0.919 Contact Map
1svcP 2 0.3833 2.9 0.919 Contact Map
2gowA 1 0.4667 2.6 0.922 Contact Map
3m7aA 1 0.3667 2.5 0.922 Contact Map
3v4yB 1 0.25 2.5 0.922 Contact Map
3odnA 1 0.3667 1.9 0.927 Contact Map
4uxaA 6 0.4333 1.9 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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