GREMLIN Database
DUF1529 - Domain of Unknown Function (DUF1259)
PFAM: PF07485 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 121 (118)
Sequences: 16627 (6674)
Seq/√Len: 614.4
META: 0.967

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_E96_R3.6571.00
79_N114_G2.8161.00
4_D18_Y2.7631.00
116_R120_D2.6731.00
107_D110_K2.6151.00
28_K35_T2.6061.00
11_G18_Y2.4781.00
2_A5_Q2.4061.00
75_A79_N2.3061.00
4_D20_V2.1091.00
73_M100_M1.9551.00
9_R22_I1.7921.00
74_K78_A1.7811.00
30_T35_T1.7621.00
110_K113_R1.7501.00
70_N74_K1.7131.00
77_R83_V1.6491.00
106_G110_K1.6391.00
55_K105_H1.6291.00
69_V91_L1.6291.00
4_D10_K1.6161.00
24_R68_E1.6101.00
109_V113_R1.5781.00
69_V86_L1.5681.00
13_V18_Y1.4931.00
70_N73_M1.4771.00
75_A78_A1.4471.00
104_G111_L1.4461.00
79_N117_A1.4061.00
88_N98_F1.3981.00
13_V16_G1.3891.00
64_L72_V1.3631.00
113_R117_A1.3601.00
27_L65_L1.3401.00
110_K114_G1.3361.00
73_M86_L1.3271.00
66_E94_Q1.3231.00
32_D92_G1.3151.00
64_L69_V1.3071.00
7_L20_V1.3061.00
108_A112_A1.2831.00
44_T62_F1.2481.00
86_L98_F1.2361.00
66_E96_R1.2301.00
58_V111_L1.2171.00
93_E97_V1.1951.00
46_A102_F1.1931.00
57_M103_W1.1851.00
67_D92_G1.1751.00
2_A6_A1.1621.00
66_E98_F1.1551.00
81_I104_G1.1521.00
90_M99_F1.1251.00
63_V97_V1.1141.00
64_L100_M1.1051.00
76_L81_I1.1041.00
72_V100_M1.1011.00
117_A120_D1.0821.00
51_T55_K1.0721.00
3_I20_V1.0621.00
22_I44_T1.0501.00
2_A109_V1.0331.00
91_L98_F1.0161.00
60_G102_F1.0071.00
31_V36_I1.0061.00
58_V102_F0.9931.00
75_A117_A0.9861.00
36_I40_M0.9861.00
19_K45_W0.9701.00
81_I114_G0.9571.00
65_L97_V0.9411.00
76_L118_A0.9301.00
49_Q57_M0.9241.00
51_T105_H0.9241.00
61_D87_H0.9191.00
114_G117_A0.9141.00
38_P42_L0.9111.00
48_F58_V0.8861.00
46_A115_L0.8801.00
70_N91_L0.8641.00
4_D13_V0.8621.00
46_A58_V0.8611.00
89_H101_H0.8601.00
86_L100_M0.8591.00
4_D11_G0.8491.00
13_V17_V0.8441.00
90_M93_E0.8251.00
56_A111_L0.8181.00
50_P55_K0.8151.00
14_N19_K0.8101.00
89_H99_F0.8031.00
79_N113_R0.8021.00
48_F56_A0.7931.00
87_H101_H0.7801.00
66_E92_G0.7801.00
62_F119_L0.7791.00
69_V98_F0.7771.00
7_L22_I0.7741.00
50_P56_A0.7601.00
36_I42_L0.7571.00
88_N93_E0.7501.00
9_R20_V0.7451.00
113_R120_D0.7431.00
72_V118_A0.7411.00
66_E91_L0.7391.00
21_T38_P0.7381.00
80_G110_K0.7361.00
27_L35_T0.7331.00
50_P53_G0.7301.00
31_V34_V0.7141.00
27_L30_T0.7071.00
19_K47_A0.6981.00
29_V36_I0.6851.00
76_L102_F0.6781.00
58_V115_L0.6781.00
21_T43_G0.6721.00
114_G118_A0.6681.00
22_I46_A0.6571.00
30_T33_G0.6551.00
50_P54_G0.6521.00
51_T54_G0.6501.00
31_V92_G0.6471.00
37_P40_M0.6461.00
77_R82_E0.6441.00
30_T94_Q0.6391.00
105_H108_A0.6371.00
106_G111_L0.6301.00
11_G20_V0.6301.00
61_D101_H0.6231.00
59_M84_T0.6231.00
78_A117_A0.6231.00
62_F72_V0.6181.00
102_F115_L0.6141.00
58_V104_G0.6131.00
110_K117_A0.6131.00
4_D12_K0.6131.00
85_A89_H0.6001.00
3_I108_A0.5981.00
6_A112_A0.5911.00
82_E103_W0.5821.00
56_A108_A0.5801.00
73_M77_R0.5781.00
12_K21_T0.5781.00
29_V97_V0.5731.00
50_P108_A0.5681.00
82_E105_H0.5661.00
63_V99_F0.5641.00
58_V81_I0.5631.00
74_K77_R0.5621.00
21_T45_W0.5581.00
71_P75_A0.5551.00
75_A114_G0.5521.00
48_F112_A0.5490.99
51_T57_M0.5490.99
25_S35_T0.5460.99
107_D113_R0.5360.99
77_R81_I0.5360.99
64_L71_P0.5310.99
17_V47_A0.5310.99
62_F76_L0.5290.99
3_I6_A0.5290.99
30_T34_V0.5230.99
5_Q10_K0.5210.99
62_F118_A0.5210.99
64_L86_L0.5180.99
29_V42_L0.5180.99
57_M105_H0.5140.99
65_L68_E0.5140.99
26_D97_V0.5130.99
67_D71_P0.5100.99
61_D89_H0.5080.99
4_D9_R0.5080.99
22_I119_L0.5060.99
54_G107_D0.5050.99
23_P43_G0.5030.99
41_G61_D0.5010.99
3_I112_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zwsA 2 0.8678 18.1 0.919 Contact Map
4x9tA 1 0.9752 15.9 0.921 Contact Map
2mdaA 2 0.6446 15.4 0.922 Contact Map
1sznA 1 0.6198 15.3 0.922 Contact Map
2jwkA 2 0.5537 14.8 0.922 Contact Map
4qq0A 1 0.8595 12.8 0.924 Contact Map
1ycgA 5 0.9339 11.8 0.926 Contact Map
1we3A 5 0.9339 10.2 0.927 Contact Map
4wgkA 2 0.9008 9.9 0.928 Contact Map
3qe2A 1 0.3223 8.7 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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