GREMLIN Database
DUF1522 - Domain of Unknown Function (DUF1522)
PFAM: PF07482 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 110 (110)
Sequences: 795 (394)
Seq/√Len: 37.6
META: 0.883

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_T76_T4.7501.00
27_S34_V3.1821.00
55_T75_L3.1031.00
69_A74_T3.0121.00
64_Q75_L2.7321.00
78_A81_Q2.6531.00
34_V42_T2.5411.00
55_T64_Q2.4771.00
67_T74_T2.2951.00
33_V41_S2.2260.99
100_A103_S2.2140.99
68_I72_A2.1950.99
5_V10_I2.1230.99
51_G55_T1.8360.98
59_L66_A1.7420.97
37_G59_L1.7370.97
3_L12_F1.6400.95
30_S72_A1.5850.94
23_V34_V1.5800.94
19_A22_A1.5500.94
26_G34_V1.5410.93
23_V27_S1.5000.92
1_S4_T1.4860.92
100_A105_T1.4630.91
17_A47_T1.4350.91
23_V26_G1.4300.90
64_Q83_A1.4290.90
30_S75_L1.4070.90
99_G109_D1.3860.89
24_P27_S1.3860.89
81_Q84_S1.3600.88
6_N9_T1.3330.87
88_A93_T1.3250.87
28_G66_A1.3200.86
45_L110_A1.3070.86
77_T83_A1.3010.86
53_V57_I1.2990.86
15_A46_G1.2660.84
65_T78_A1.2430.83
12_F57_I1.1990.81
87_I91_A1.1970.80
17_A29_V1.1650.79
98_T101_D1.1320.77
96_T104_I1.1170.76
14_N48_G1.0640.72
99_G108_A1.0490.71
47_T53_V1.0460.71
37_G66_A1.0420.70
33_V75_L1.0390.70
64_Q77_T1.0280.69
59_L73_A1.0130.68
95_S104_I1.0040.67
61_S97_G0.9980.67
18_P43_V0.9980.67
66_A73_A0.9780.65
68_I71_G0.9570.64
92_L104_I0.9560.64
18_P44_Y0.9540.63
27_S42_T0.9500.63
16_A19_A0.9410.62
63_V81_Q0.9310.62
69_A73_A0.9200.61
20_A23_V0.9060.59
61_S99_G0.9000.59
45_L96_T0.8860.58
93_T99_G0.8740.57
54_L92_L0.8640.56
15_A43_V0.8530.55
46_G93_T0.8370.53
97_G102_L0.8320.53
33_V42_T0.8190.52
93_T97_G0.8100.51
30_S74_T0.8090.51
1_S15_A0.8060.51
4_T15_A0.8000.50
6_N14_N0.7910.49
72_A76_T0.7840.49
28_G73_A0.7810.48
27_S71_G0.7790.48
51_G65_T0.7720.48
88_A106_G0.7680.47
35_T68_I0.7680.47
65_T77_T0.7630.47
28_G68_I0.7620.47
4_T9_T0.7590.46
31_G55_T0.7550.46
77_T84_S0.7370.45
61_S96_T0.7360.44
23_V72_A0.7350.44
91_A106_G0.7330.44
23_V28_G0.7270.44
46_G53_V0.7250.43
72_A104_I0.7250.43
48_G53_V0.7180.43
61_S106_G0.7080.42
4_T100_A0.7070.42
86_I89_S0.7030.42
86_I93_T0.7020.41
65_T68_I0.6970.41
35_T52_D0.6970.41
6_N22_A0.6880.40
3_L57_I0.6870.40
26_G68_I0.6820.40
64_Q76_T0.6800.40
15_A49_T0.6760.39
16_A48_G0.6760.39
8_K91_A0.6750.39
26_G30_S0.6740.39
97_G108_A0.6690.39
84_S104_I0.6650.38
77_T82_T0.6640.38
47_T50_V0.6600.38
33_V64_Q0.6590.38
92_L95_S0.6520.37
50_V68_I0.6510.37
6_N63_V0.6460.37
14_N46_G0.6430.36
95_S108_A0.6380.36
16_A63_V0.6380.36
7_G10_I0.6360.36
43_V64_Q0.6330.36
50_V53_V0.6320.36
30_S33_V0.6300.35
6_N40_N0.6270.35
9_T13_K0.6230.35
34_V68_I0.6200.35
93_T98_T0.6110.34
82_T106_G0.6070.34
43_V78_A0.6060.33
89_S98_T0.6060.33
91_A105_T0.5990.33
97_G101_D0.5950.33
10_I24_P0.5940.33
29_V32_N0.5930.32
40_N53_V0.5920.32
28_G76_T0.5860.32
107_K110_A0.5820.32
19_A27_S0.5810.32
99_G105_T0.5780.31
79_S82_T0.5760.31
98_T102_L0.5680.31
29_V34_V0.5640.30
9_T14_N0.5530.29
99_G106_G0.5440.29
92_L97_G0.5440.29
4_T46_G0.5370.28
33_V65_T0.5330.28
24_P28_G0.5320.28
27_S68_I0.5260.27
3_L13_K0.5260.27
94_L106_G0.5250.27
106_G109_D0.5230.27
33_V66_A0.5150.27
50_V87_I0.5140.27
68_I73_A0.5120.26
18_P63_V0.5100.26
48_G107_K0.5090.26
21_A32_N0.5070.26
95_S109_D0.5070.26
4_T14_N0.5070.26
87_I93_T0.5070.26
2_T38_N0.5060.26
20_A72_A0.5020.26
2_T8_K0.5010.26
33_V72_A0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4peuA 1 0.8636 13.7 0.933 Contact Map
1b5fA 2 0.4091 4.4 0.946 Contact Map
1yduA 1 0.3091 3.8 0.948 Contact Map
4mtkA 4 0.8 3.1 0.95 Contact Map
1qcxA 1 0.7455 2.9 0.951 Contact Map
1lmiA 1 0.5091 2.5 0.952 Contact Map
1pclA 1 0.8 2.5 0.953 Contact Map
2l7yA 1 0.2273 2.2 0.954 Contact Map
3syjA 2 0.8 2 0.955 Contact Map
3szeA 1 0.8 1.9 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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