GREMLIN Database
DUF1517 - Protein of unknown function (DUF1517)
PFAM: PF07466 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 288 (284)
Sequences: 690 (543)
Seq/√Len: 32.2
META: 0.646

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_F263_L3.7261.00
182_E185_K3.2831.00
225_V249_L3.1321.00
24_R27_G2.9941.00
191_L267_Q2.8961.00
26_S29_G2.8891.00
31_G34_G2.8761.00
174_T177_R2.8041.00
186_F265_T2.7931.00
236_I241_D2.7611.00
72_G76_G2.7461.00
21_S26_S2.6331.00
5_G9_G2.6161.00
25_S28_G2.6151.00
20_Y23_P2.6011.00
147_L151_R2.5731.00
172_E176_N2.5641.00
122_D125_R2.5531.00
30_G33_G2.3850.99
237_N241_D2.3600.99
108_L159_A2.2560.99
50_F53_L2.2180.99
132_T176_N2.1370.98
81_A85_A2.1180.98
132_T137_G2.0880.98
117_R120_Q2.0210.98
126_L141_V2.0140.98
122_D138_L2.0000.98
26_S30_G1.9850.98
146_T250_G1.9800.98
124_N267_Q1.9330.97
50_F56_F1.9260.97
18_R21_S1.8950.97
119_L155_Y1.8830.97
108_L161_A1.8740.96
258_L277_E1.8690.96
53_L56_F1.8540.96
48_F51_P1.8540.96
128_E200_Q1.8500.96
238_S241_D1.8450.96
221_V271_D1.7970.96
134_T229_G1.7930.95
27_G30_G1.7920.95
110_V242_L1.7760.95
135_P138_L1.7630.95
70_I74_I1.7530.95
164_Q174_T1.7410.95
40_G43_Y1.7370.95
125_R129_T1.7210.94
13_F172_E1.7050.94
179_S242_L1.7030.94
5_G10_G1.6880.94
80_N84_R1.6830.94
52_F55_P1.6650.93
268_A271_D1.6570.93
185_K263_L1.6490.93
275_E279_L1.6400.93
33_G36_G1.6400.93
7_R13_F1.6310.93
68_L72_G1.6280.92
52_F56_F1.6180.92
217_E271_D1.6170.92
182_E220_V1.6160.92
47_G52_F1.6150.92
24_R30_G1.5540.91
190_T267_Q1.5510.90
165_Q230_K1.5480.90
6_G10_G1.5440.90
121_R269_E1.5360.90
214_E271_D1.5270.90
143_Q180_L1.5110.89
134_T137_G1.5030.89
121_R125_R1.4940.89
143_Q176_N1.4910.89
24_R28_G1.4690.88
23_P27_G1.4660.88
263_L267_Q1.4460.87
41_G45_G1.4410.87
6_G9_G1.4340.87
7_R12_S1.4270.86
28_G31_G1.4150.86
51_P54_L1.4130.86
183_R189_E1.3900.85
275_E281_E1.3880.85
23_P29_G1.3830.85
63_G76_G1.3620.84
138_L260_L1.3590.83
39_Y43_Y1.3570.83
109_Q282_Y1.3060.81
67_G73_A1.2990.81
139_A179_S1.2800.80
122_D148_A1.2790.80
51_P55_P1.2630.79
8_I145_T1.2630.79
173_A251_S1.2560.78
19_S22_S1.2520.78
180_L250_G1.2490.78
107_K178_L1.2400.77
41_G44_G1.2350.77
109_Q182_E1.2320.77
136_E269_E1.2300.77
16_P23_P1.2230.76
32_G37_G1.2170.76
46_G50_F1.2120.76
115_S215_P1.2050.75
145_T262_V1.1930.75
132_T138_L1.1800.74
148_A271_D1.1780.74
42_G50_F1.1760.73
178_L182_E1.1760.73
221_V277_E1.1760.73
144_E148_A1.1550.72
29_G33_G1.1420.71
188_E204_A1.1420.71
36_G39_Y1.1420.71
170_S223_L1.1250.70
8_I141_V1.1210.70
111_G142_L1.1150.69
27_G32_G1.1030.69
110_V161_A1.1010.68
223_L249_L1.0980.68
134_T278_L1.0940.68
47_G50_F1.0900.68
181_A284_D1.0830.67
69_L73_A1.0660.66
100_N106_A1.0650.66
19_S25_S1.0560.65
108_L241_D1.0530.65
249_L271_D1.0460.64
135_P177_R1.0450.64
28_G37_G1.0430.64
179_S196_G1.0380.64
265_T287_L1.0330.63
21_S31_G1.0320.63
274_T279_L1.0320.63
218_Y273_L1.0270.63
24_R29_G1.0080.61
111_G119_L1.0030.61
273_L276_D0.9940.60
30_G34_G0.9890.60
207_L211_G0.9860.60
32_G35_S0.9830.59
75_A79_V0.9780.59
259_A272_T0.9780.59
70_I202_S0.9700.58
162_E284_D0.9690.58
109_Q178_L0.9640.58
66_F70_I0.9620.58
197_Q274_T0.9600.58
17_S20_Y0.9490.57
5_G11_G0.9460.56
226_A253_P0.9450.56
120_Q158_Y0.9430.56
70_I77_F0.9420.56
4_S271_D0.9410.56
218_Y276_D0.9390.56
265_T281_E0.9380.56
182_E222_T0.9370.56
21_S84_R0.9350.56
39_Y42_G0.9250.55
2_A8_I0.9240.55
138_L271_D0.9220.55
159_A242_L0.9190.54
152_H274_T0.9050.53
172_E226_A0.9020.53
204_A207_L0.8980.53
16_P25_S0.8930.52
225_V228_R0.8880.52
163_S286_K0.8870.52
155_Y192_S0.8870.52
144_E153_P0.8840.51
235_K241_D0.8830.51
34_G48_F0.8820.51
147_L180_L0.8800.51
70_I73_A0.8790.51
15_S25_S0.8760.51
144_E151_R0.8720.50
161_A236_I0.8710.50
140_Q199_R0.8680.50
15_S19_S0.8630.50
8_I262_V0.8600.49
93_G134_T0.8600.49
160_G284_D0.8590.49
105_V260_L0.8590.49
277_E287_L0.8570.49
163_S226_A0.8540.49
107_K160_G0.8530.49
21_S25_S0.8480.48
71_F75_A0.8420.48
118_S121_R0.8410.48
159_A234_P0.8370.48
158_Y275_E0.8310.47
22_S25_S0.8300.47
224_L278_L0.8280.47
147_L150_L0.8260.47
124_N159_A0.8240.46
208_P211_G0.8220.46
113_L218_Y0.8210.46
126_L242_L0.8180.46
22_S30_G0.8150.46
29_G32_G0.8140.46
119_L148_A0.8100.45
108_L154_E0.8060.45
142_L145_T0.8020.45
16_P190_T0.7980.44
101_P168_L0.7980.44
34_G37_G0.7960.44
54_L72_G0.7960.44
169_E271_D0.7910.44
54_L59_F0.7900.44
228_R252_I0.7900.44
28_G32_G0.7900.44
64_G68_L0.7810.43
58_G76_G0.7800.43
105_V202_S0.7780.43
123_L149_L0.7760.43
41_G46_G0.7750.43
108_L233_L0.7700.42
42_G45_G0.7670.42
7_R185_K0.7660.42
229_G232_K0.7600.41
33_G44_G0.7600.41
105_V169_E0.7590.41
33_G37_G0.7590.41
171_A261_E0.7540.41
276_D280_A0.7510.41
127_A283_P0.7500.41
42_G47_G0.7480.40
138_L275_E0.7480.40
22_S27_G0.7470.40
74_I78_L0.7440.40
85_A243_R0.7430.40
148_A153_P0.7430.40
114_A276_D0.7410.40
134_T258_L0.7400.40
107_K284_D0.7400.40
182_E224_L0.7380.40
132_T194_V0.7330.39
107_K162_E0.7330.39
247_R278_L0.7290.39
229_G263_L0.7280.39
30_G36_G0.7260.39
74_I85_A0.7260.39
273_L279_L0.7250.39
121_R223_L0.7220.38
230_K256_D0.7220.38
171_A221_V0.7220.38
218_Y275_E0.7210.38
226_A259_A0.7180.38
109_Q222_T0.7170.38
180_L263_L0.7160.38
31_G37_G0.7160.38
46_G52_F0.7140.38
131_D252_I0.7130.38
216_G271_D0.7100.37
173_A238_S0.7100.37
34_G38_G0.7080.37
225_V262_V0.7030.37
236_I245_A0.7010.37
148_A156_W0.6990.37
155_Y160_G0.6980.36
71_F79_V0.6960.36
228_R258_L0.6950.36
152_H155_Y0.6950.36
85_A88_G0.6930.36
202_S252_I0.6890.36
141_V182_E0.6890.36
57_F66_F0.6870.36
219_I273_L0.6860.36
269_E278_L0.6850.35
203_A243_R0.6850.35
182_E263_L0.6830.35
100_N103_V0.6830.35
34_G41_G0.6820.35
179_S182_E0.6810.35
106_A227_T0.6810.35
244_Q248_Q0.6750.35
79_V240_E0.6730.35
223_L260_L0.6720.34
25_S30_G0.6710.34
241_D255_D0.6690.34
16_P55_P0.6690.34
141_V237_N0.6670.34
111_G133_S0.6650.34
267_Q273_L0.6640.34
38_G42_G0.6630.34
33_G38_G0.6600.34
68_L76_G0.6540.33
25_S29_G0.6520.33
103_V280_A0.6510.33
177_R287_L0.6510.33
260_L263_L0.6490.33
35_S70_I0.6480.33
77_F88_G0.6470.33
50_F54_L0.6440.32
15_S20_Y0.6390.32
83_R86_G0.6370.32
126_L145_T0.6360.32
74_I99_S0.6360.32
192_S267_Q0.6360.32
145_T187_S0.6350.32
190_T271_D0.6340.32
73_A77_F0.6330.32
191_L263_L0.6330.32
260_L276_D0.6330.32
20_Y25_S0.6320.32
97_Y256_D0.6320.32
119_L245_A0.6280.31
141_V259_A0.6250.31
71_F257_L0.6250.31
19_S82_F0.6230.31
247_R253_P0.6230.31
84_R268_A0.6220.31
104_S279_L0.6220.31
53_L70_I0.6200.31
9_G132_T0.6140.30
133_S184_S0.6110.30
267_Q271_D0.6100.30
73_A95_G0.6070.30
14_R88_G0.6050.30
59_F82_F0.6050.30
270_G273_L0.6030.30
185_K282_Y0.5970.29
75_A229_G0.5950.29
153_P243_R0.5920.29
182_E282_Y0.5910.29
229_G234_P0.5900.29
25_S35_S0.5890.29
207_L249_L0.5870.28
74_I97_Y0.5840.28
27_G34_G0.5840.28
138_L220_V0.5840.28
146_T274_T0.5820.28
281_E287_L0.5820.28
193_N219_I0.5820.28
59_F62_G0.5800.28
142_L182_E0.5790.28
97_Y169_E0.5790.28
142_L147_L0.5780.28
188_E251_S0.5750.28
169_E231_L0.5730.28
147_L153_P0.5700.27
238_S253_P0.5690.27
107_K281_E0.5670.27
45_G51_P0.5660.27
91_G202_S0.5650.27
204_A239_A0.5650.27
220_V271_D0.5640.27
227_T260_L0.5630.27
107_K265_T0.5620.27
98_S232_K0.5610.27
38_G41_G0.5590.27
163_S220_V0.5580.27
175_F185_K0.5570.27
46_G51_P0.5570.27
108_L270_G0.5560.26
100_N218_Y0.5550.26
47_G51_P0.5530.26
29_G87_G0.5530.26
261_E266_P0.5530.26
178_L224_L0.5510.26
113_L217_E0.5510.26
185_K220_V0.5500.26
272_T279_L0.5490.26
216_G274_T0.5490.26
42_G51_P0.5490.26
242_L271_D0.5490.26
96_G100_N0.5490.26
93_G97_Y0.5480.26
77_F81_A0.5460.26
65_L82_F0.5450.26
127_A172_E0.5440.26
144_E175_F0.5420.26
142_L249_L0.5410.25
4_S56_F0.5400.25
156_W243_R0.5390.25
22_S26_S0.5390.25
218_Y279_L0.5390.25
42_G46_G0.5380.25
46_G69_L0.5380.25
75_A78_L0.5370.25
47_G55_P0.5370.25
276_D281_E0.5360.25
267_Q272_T0.5350.25
111_G153_P0.5350.25
135_P226_A0.5340.25
212_S276_D0.5340.25
64_G69_L0.5340.25
33_G40_G0.5340.25
145_T226_A0.5330.25
109_Q112_L0.5320.25
120_Q127_A0.5300.25
241_D248_Q0.5290.25
35_S43_Y0.5290.25
261_E264_W0.5250.25
174_T257_L0.5230.24
278_L282_Y0.5210.24
67_G72_G0.5210.24
92_G262_V0.5210.24
23_P33_G0.5200.24
78_L202_S0.5190.24
29_G205_A0.5180.24
46_G60_G0.5170.24
8_I13_F0.5160.24
37_G41_G0.5150.24
178_L194_V0.5150.24
156_W287_L0.5150.24
156_W184_S0.5140.24
103_V275_E0.5140.24
2_A281_E0.5130.24
103_V156_W0.5130.24
110_V191_L0.5120.24
4_S15_S0.5120.24
43_Y46_G0.5100.24
19_S28_G0.5100.24
112_L116_A0.5090.24
218_Y223_L0.5090.24
78_L178_L0.5080.23
188_E271_D0.5060.23
75_A125_R0.5060.23
280_A283_P0.5050.23
134_T138_L0.5040.23
53_L76_G0.5030.23
247_R279_L0.5030.23
150_L233_L0.5020.23
50_F61_G0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rfyA 2 0.6146 16.9 0.965 Contact Map
3ajiB 1 0.2535 15.7 0.966 Contact Map
4ml2A 1 0.0938 13.9 0.966 Contact Map
2pk2A 3 0 11.4 0.968 Contact Map
2z86A 2 0.4514 8.7 0.969 Contact Map
4m9rA 2 0.3125 7.9 0.97 Contact Map
2krkA 1 0.2917 7.5 0.97 Contact Map
2mu3A 1 0.2257 7.4 0.97 Contact Map
3k9dA 2 0.5694 6.8 0.971 Contact Map
2ga1A 2 0.1736 6.8 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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