GREMLIN Database
DUF1516 - Protein of unknown function (DUF1516)
PFAM: PF07457 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 108 (108)
Sequences: 542 (408)
Seq/√Len: 39.3
META: 0.288

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_W96_L3.7411.00
11_A44_I2.9811.00
35_M39_L2.6621.00
34_H82_V2.4021.00
10_L40_F2.3551.00
49_I53_I2.3461.00
32_I36_I2.3311.00
16_F20_F2.2791.00
80_I94_W2.2501.00
96_L100_A2.1750.99
73_V104_T2.1660.99
82_V86_K2.0220.99
3_L47_T2.0060.99
42_L46_I1.8920.98
70_G73_V1.8910.98
92_G96_L1.8430.98
75_G79_M1.7520.97
23_K84_K1.7450.97
17_V21_L1.7350.97
2_H6_T1.6680.96
62_L107_L1.6550.96
7_S43_L1.6540.96
14_L37_L1.5890.95
45_I75_G1.5630.95
80_I97_F1.5610.94
72_W76_L1.5350.94
4_H48_G1.4690.92
52_L67_G1.4600.92
94_W97_F1.4530.92
98_I102_I1.4400.92
91_K95_I1.3950.90
11_A37_L1.3800.90
18_A33_V1.3800.90
76_L93_F1.3090.87
45_I49_I1.2740.86
22_Y34_H1.2560.85
70_G104_T1.2310.84
65_L68_L1.2110.83
72_W100_A1.2050.82
83_R88_K1.2030.82
69_L104_T1.1900.82
46_I49_I1.1790.81
69_L103_L1.1660.80
52_L63_Y1.1490.79
5_I8_W1.1070.77
61_M64_I1.1060.77
52_L55_Y1.0620.74
56_F60_P1.0560.73
1_T5_I1.0520.73
5_I9_V1.0460.72
48_G66_K1.0400.72
64_I68_L1.0370.72
22_Y30_A1.0330.71
15_F77_M1.0320.71
18_A30_A1.0310.71
18_A81_L1.0300.71
76_L96_L1.0300.71
12_I105_L1.0210.71
3_L6_T1.0000.69
69_L107_L0.9710.67
76_L80_I0.9400.64
102_I106_Y0.9400.64
31_K35_M0.9300.63
25_G31_K0.9200.62
13_I17_V0.9180.62
61_M65_L0.9130.62
43_L47_T0.9080.61
76_L90_T0.9070.61
60_P65_L0.9000.61
19_L84_K0.8570.57
69_L72_W0.8530.57
31_K39_L0.8440.56
38_R78_E0.8390.55
34_H81_L0.8380.55
16_F86_K0.8240.54
29_G33_V0.8190.54
40_F46_I0.8160.53
56_F64_I0.8140.53
10_L71_L0.7890.51
4_H66_K0.7890.51
11_A73_V0.7830.50
12_I16_F0.7830.50
6_T10_L0.7400.46
90_T94_W0.7400.46
74_I80_I0.7320.46
5_I67_G0.7290.45
24_K33_V0.7280.45
41_Y74_I0.7270.45
92_G100_A0.7180.44
7_S19_L0.7160.44
59_F64_I0.6990.43
30_A39_L0.6980.43
19_L71_L0.6960.42
21_L33_V0.6890.42
49_I56_F0.6890.42
72_W79_M0.6870.42
44_I59_F0.6810.41
66_K78_E0.6790.41
7_S10_L0.6790.41
80_I93_F0.6770.41
50_G58_G0.6750.41
16_F106_Y0.6740.40
5_I70_G0.6710.40
70_G78_E0.6710.40
75_G82_V0.6690.40
93_F99_I0.6670.40
46_I50_G0.6630.39
77_M101_L0.6610.39
14_L40_F0.6550.39
86_K89_P0.6530.39
65_L93_F0.6520.39
69_L73_V0.6480.38
30_A34_H0.6460.38
52_L64_I0.6460.38
6_T9_V0.6440.38
13_I89_P0.6390.37
39_L42_L0.6370.37
92_G106_Y0.6370.37
16_F99_I0.6360.37
51_L66_K0.6340.37
66_K70_G0.6300.37
84_K98_I0.6220.36
29_G32_I0.6210.36
62_L103_L0.6200.36
53_I56_F0.6120.35
68_L71_L0.6100.35
75_G93_F0.6060.35
76_L100_A0.6040.35
28_K72_W0.6020.34
30_A84_K0.6000.34
28_K32_I0.5990.34
99_I103_L0.5980.34
44_I83_R0.5970.34
13_I79_M0.5940.34
16_F42_L0.5920.34
44_I70_G0.5890.33
80_I95_I0.5750.32
68_L106_Y0.5700.32
79_M82_V0.5670.32
5_I44_I0.5650.31
40_F43_L0.5630.31
52_L56_F0.5620.31
80_I90_T0.5560.31
55_Y59_F0.5500.30
62_L65_L0.5440.30
49_I61_M0.5360.29
20_F98_I0.5310.29
97_F102_I0.5270.28
11_A70_G0.5250.28
22_Y84_K0.5240.28
32_I85_K0.5170.28
79_M83_R0.5150.28
69_L100_A0.5140.28
39_L69_L0.5130.27
27_A30_A0.5110.27
37_L81_L0.5080.27
76_L103_L0.5060.27
66_K108_G0.5050.27
17_V33_V0.5050.27
27_A71_L0.5030.27
15_F40_F0.5020.27
43_L70_G0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.8889 3.4 0.925 Contact Map
4hfiA 3 0.5278 2.9 0.927 Contact Map
1skhA 1 0.2685 2.6 0.929 Contact Map
4o6yA 2 1 2.1 0.932 Contact Map
4xp4A 1 0.7222 2 0.933 Contact Map
3pjzA 2 0.713 2 0.933 Contact Map
2l2tA 2 0.3704 1.4 0.938 Contact Map
4u2pA 4 0.1944 1.4 0.938 Contact Map
2jwaA 2 0.3981 1.4 0.939 Contact Map
4fbzA 3 0.5185 1.4 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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