GREMLIN Database
CHRD - CHRD domain
PFAM: PF07452 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 101 (100)
Sequences: 38414 (28298)
Seq/√Len: 2829.8
META: 0.965

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_S9_Q3.0181.00
48_I83_L2.5821.00
47_H88_H2.4701.00
11_V56_N2.4151.00
10_E86_N2.2121.00
50_G77_A2.1591.00
78_L83_L1.8931.00
45_A62_P1.8451.00
50_G60_V1.8371.00
23_A38_L1.8371.00
3_A99_G1.8211.00
32_G75_V1.6861.00
23_A85_V1.6691.00
49_H88_H1.6651.00
77_A82_N1.6581.00
77_A83_L1.6491.00
60_V74_Q1.6361.00
76_A80_A1.5221.00
40_F87_V1.4901.00
4_T22_T1.4881.00
48_I101_L1.4741.00
11_V54_G1.4071.00
61_V74_Q1.4061.00
9_Q53_A1.3761.00
27_L75_V1.3651.00
60_V83_L1.3561.00
15_V92_F1.3541.00
72_A76_A1.3381.00
75_V79_L1.3221.00
52_A55_V1.2991.00
28_D31_G1.2971.00
66_P69_G1.2971.00
20_T41_S1.2871.00
50_G83_L1.2841.00
24_T37_T1.2321.00
63_L85_V1.1981.00
74_Q77_A1.1751.00
73_A77_A1.1671.00
25_V85_V1.1661.00
28_D33_T1.1611.00
92_F96_E1.1601.00
74_Q83_L1.1561.00
68_G71_G1.1561.00
46_A87_V1.1251.00
44_T90_A1.1231.00
40_F43_L1.1211.00
25_V36_Y1.1151.00
67_G71_G1.1131.00
32_G72_A1.1081.00
52_A82_N1.1061.00
47_H59_V1.1041.00
7_G15_V1.0701.00
36_Y48_I1.0621.00
31_G79_L1.0471.00
67_G70_G1.0411.00
89_T96_E1.0271.00
11_V14_A1.0161.00
59_V62_P1.0131.00
25_V34_L1.0021.00
15_V18_T1.0021.00
5_L85_V0.9911.00
3_A25_V0.9831.00
50_G82_N0.9821.00
90_A93_P0.9721.00
50_G57_G0.9511.00
48_I63_L0.9401.00
27_L34_L0.9361.00
51_G57_G0.9291.00
5_L21_G0.9281.00
64_T67_G0.9281.00
22_T39_T0.9271.00
26_T35_T0.8841.00
49_H86_N0.8821.00
65_G70_G0.8791.00
7_G17_S0.8611.00
62_P65_G0.8581.00
19_A43_L0.8561.00
28_D32_G0.8561.00
73_A76_A0.8551.00
2_T22_T0.8451.00
74_Q78_L0.8241.00
76_A79_L0.8221.00
49_H58_P0.8211.00
17_S96_E0.8201.00
9_Q54_G0.8181.00
49_H59_V0.7991.00
66_P70_G0.7841.00
51_G82_N0.7801.00
84_Y98_R0.7731.00
45_A59_V0.7691.00
44_T89_T0.7691.00
19_A97_I0.7601.00
2_T24_T0.7531.00
89_T92_F0.7511.00
72_A75_V0.7451.00
3_A23_A0.7421.00
36_Y85_V0.7231.00
77_A80_A0.7191.00
47_H86_N0.7181.00
51_G100_Q0.7171.00
24_T39_T0.7151.00
13_P16_D0.7111.00
50_G74_Q0.6931.00
27_L31_G0.6831.00
5_L87_V0.6831.00
65_G69_G0.6791.00
57_G60_V0.6791.00
4_T20_T0.6781.00
64_T71_G0.6781.00
62_P67_G0.6741.00
89_T95_G0.6731.00
51_G77_A0.6721.00
40_F64_T0.6601.00
46_A63_L0.6531.00
53_A100_Q0.6511.00
36_Y64_T0.6471.00
47_H62_P0.6461.00
44_T93_P0.6441.00
48_I61_V0.6431.00
66_P71_G0.6411.00
12_P56_N0.6401.00
35_T83_L0.6221.00
27_L32_G0.6071.00
27_L79_L0.6041.00
38_L85_V0.5961.00
26_T37_T0.5941.00
5_L97_I0.5931.00
45_A88_H0.5901.00
36_Y61_V0.5861.00
27_L78_L0.5841.00
21_G87_V0.5821.00
13_P18_T0.5811.00
10_E15_V0.5751.00
20_T42_G0.5671.00
59_V88_H0.5631.00
25_V48_I0.5601.00
8_A16_D0.5591.00
16_D92_F0.5581.00
22_T37_T0.5461.00
28_D35_T0.5411.00
84_Y88_H0.5241.00
14_A18_T0.5181.00
86_N98_R0.5161.00
65_G68_G0.5151.00
26_T29_T0.5131.00
23_A26_T0.5091.00
38_L87_V0.5071.00
52_A57_G0.5071.00
23_A36_Y0.5061.00
29_T32_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u9yA 3 0.3861 7.4 0.896 Contact Map
4twbA 2 0.3861 6.7 0.898 Contact Map
3lrtA 2 0.3861 6 0.9 Contact Map
1wscA 1 0.7129 6 0.9 Contact Map
3s5jB 2 0.396 5.4 0.902 Contact Map
2j6pA 4 0.3663 4.4 0.906 Contact Map
2vvfA 3 0.9307 4.2 0.907 Contact Map
3dahA 5 0.4059 3.7 0.91 Contact Map
4bczA 1 0.7822 3.4 0.911 Contact Map
1d0nA 5 0.5644 2.9 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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