DUF1512 - PFAM28P - GREMLIN Contacts

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DUF1512 - Protein of unknown function (DUF1512)

PFAM:	PF07431	Sequences: IILQLIWILFFILFFYGFGQRIQLYIMLREIEKSLRKLKKMRDEARKEAIKYIKKIGKKDPTKRVDRFLEYFTIEPVDLDPAGIVKKLEHILDVREDRFKDEVKRLAPNADEVEVSNLENLLEAAMALNQIYKIVRHYYLLGKKTKNLYLIMQLQMILPLIMEEAEAYAKALKAFKKGQPIGDGIGPLVAAKLMLGKEKKVREIAKDTVVAEVEIEGRKLYVLKAEGPGGTVGKPGEAVEKLIEENGGKIARIIMIDAALKLEGEKTGEVAEGVGAAIGGPGVEKFKIEEVATKYKIPLYAIVIKMSIEEAITPMRKEIADAVDKVIERVKRIIRERTKEGDTVIVAGVGNTIGVG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	356 (352)
Sequences:	857 (559)
Seq/√Len:	29.8
META:	0.93

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
190_A	222_V	5.989	1.00
216_E	335_R	5.317	1.00
203_E	226_E	4.982	1.00
184_G	355_V	4.086	1.00
338_T	342_D	3.954	1.00
215_I	220_L	3.933	1.00
46_R	66_D	3.831	1.00
317_K	321_D	3.608	1.00
212_E	219_K	3.588	1.00
111_D	114_E	3.584	1.00
253_I	292_A	3.555	1.00
39_K	43_D	3.430	1.00
280_G	283_V	3.382	1.00
185_I	322_A	3.340	1.00
239_V	347_A	3.136	1.00
252_R	300_Y	3.131	1.00
120_N	230_G	2.997	1.00
316_R	319_I	2.921	1.00
255_M	276_A	2.876	1.00
93_D	234_K	2.806	1.00
193_L	346_V	2.690	1.00
256_I	346_V	2.614	1.00
208_T	223_L	2.524	0.99
104_K	115_V	2.515	0.99
79_L	85_V	2.399	0.99
221_Y	343_T	2.393	0.99
185_I	304_I	2.388	0.99
215_I	335_R	2.305	0.99
339_K	342_D	2.289	0.99
194_M	211_A	2.192	0.98
192_K	324_D	2.173	0.98
239_V	345_I	2.089	0.98
302_I	326_V	2.084	0.98
77_V	85_V	2.068	0.98
89_E	93_D	2.062	0.98
136_R	264_G	2.002	0.97
332_R	336_E	1.989	0.97
188_L	355_V	1.968	0.97
267_T	310_E	1.965	0.97
92_L	281_P	1.941	0.96
267_T	316_R	1.916	0.96
68_F	122_L	1.898	0.96
322_A	326_V	1.897	0.96
255_M	288_I	1.892	0.96
207_D	231_T	1.870	0.96
220_L	346_V	1.863	0.95
276_A	288_I	1.859	0.95
129_N	133_K	1.859	0.95
95_R	123_E	1.836	0.95
80_D	83_G	1.816	0.95
87_K	280_G	1.777	0.94
65_V	122_L	1.774	0.94
75_E	78_D	1.743	0.93
157_I	161_I	1.712	0.93
302_I	330_V	1.712	0.93
260_L	311_A	1.707	0.93
20_Q	23_Q	1.701	0.93
243_I	253_I	1.670	0.92
85_V	280_G	1.638	0.91
216_E	331_K	1.634	0.91
219_K	343_T	1.630	0.91
185_I	326_V	1.620	0.91
70_E	129_N	1.610	0.90
194_M	222_V	1.601	0.90
85_V	286_F	1.595	0.90
205_A	237_E	1.553	0.89
266_K	318_E	1.541	0.88
213_V	222_V	1.541	0.88
259_A	271_A	1.539	0.88
79_L	84_I	1.538	0.88
38_L	165_A	1.534	0.88
100_K	206_K	1.531	0.88
210_V	221_Y	1.518	0.87
79_L	88_L	1.507	0.87
39_K	136_R	1.490	0.86
326_V	330_V	1.479	0.86
72_F	303_V	1.479	0.86
328_E	331_K	1.475	0.86
270_V	323_V	1.475	0.86
304_I	326_V	1.468	0.86
112_E	226_E	1.458	0.85
221_Y	246_N	1.447	0.85
4_Q	11_F	1.436	0.84
69_L	125_A	1.430	0.84
330_V	346_V	1.389	0.82
217_G	340_E	1.386	0.82
232_V	235_P	1.377	0.82
77_V	236_G	1.374	0.82
104_K	112_E	1.356	0.81
77_V	286_F	1.353	0.81
32_E	143_K	1.352	0.81
73_T	91_I	1.344	0.80
223_L	242_L	1.340	0.80
175_F	181_I	1.334	0.80
35_L	132_Y	1.329	0.79
87_K	283_V	1.324	0.79
193_L	215_I	1.321	0.79
184_G	353_I	1.320	0.79
89_E	287_K	1.318	0.79
237_E	287_K	1.285	0.77
214_E	219_K	1.281	0.77
117_N	229_G	1.267	0.76
185_I	323_V	1.267	0.76
256_I	302_I	1.265	0.76
325_K	328_E	1.262	0.76
49_A	125_A	1.259	0.75
80_D	290_E	1.253	0.75
85_V	91_I	1.252	0.75
97_D	206_K	1.246	0.75
286_F	290_E	1.241	0.74
85_V	236_G	1.232	0.74
127_A	168_Y	1.227	0.74
302_I	333_I	1.220	0.73
5_L	9_L	1.210	0.72
185_I	319_I	1.196	0.72
292_A	299_L	1.192	0.71
88_L	281_P	1.189	0.71
15_F	19_G	1.178	0.70
107_A	118_L	1.176	0.70
77_V	285_K	1.173	0.70
270_V	302_I	1.171	0.70
256_I	330_V	1.167	0.70
37_K	166_E	1.167	0.70
47_K	51_K	1.164	0.69
193_L	222_V	1.160	0.69
142_G	356_G	1.159	0.69
210_V	242_L	1.158	0.69
103_V	178_G	1.154	0.69
239_V	349_V	1.148	0.68
174_A	314_P	1.143	0.68
2_I	7_W	1.136	0.68
205_A	210_V	1.133	0.67
120_N	231_T	1.126	0.67
74_I	277_A	1.118	0.66
151_I	355_V	1.117	0.66
185_I	189_V	1.116	0.66
245_E	248_G	1.107	0.66
149_Y	153_Q	1.099	0.65
50_I	62_T	1.094	0.65
121_L	176_K	1.094	0.65
116_S	231_T	1.086	0.64
243_I	297_I	1.085	0.64
149_Y	156_M	1.069	0.63
315_M	319_I	1.068	0.63
8_I	11_F	1.064	0.62
217_G	220_L	1.061	0.62
83_G	290_E	1.056	0.62
276_A	283_V	1.051	0.61
142_G	153_Q	1.045	0.61
131_I	165_A	1.035	0.60
168_Y	281_P	1.024	0.59
148_L	152_M	1.019	0.59
130_Q	134_I	1.014	0.59
141_L	163_E	1.012	0.58
255_M	308_I	1.007	0.58
84_I	87_K	1.005	0.58
163_E	309_E	1.001	0.58
243_I	250_I	0.999	0.57
136_R	140_L	0.996	0.57
83_G	286_F	0.992	0.57
71_Y	300_Y	0.990	0.57
89_E	237_E	0.985	0.56
113_V	231_T	0.984	0.56
92_L	97_D	0.979	0.56
77_V	292_A	0.978	0.56
57_G	61_P	0.978	0.56
52_Y	118_L	0.974	0.56
164_E	255_M	0.967	0.55
100_K	116_S	0.967	0.55
158_L	162_M	0.963	0.55
270_V	325_K	0.954	0.54
332_R	335_R	0.952	0.54
212_E	246_N	0.952	0.54
85_V	283_V	0.951	0.54
7_W	14_F	0.943	0.53
208_T	260_L	0.939	0.53
63_K	66_D	0.939	0.53
306_M	310_E	0.936	0.53
249_K	291_V	0.931	0.52
173_K	256_I	0.923	0.52
214_E	217_G	0.923	0.52
184_G	188_L	0.915	0.51
290_E	294_K	0.914	0.51
123_E	235_P	0.909	0.50
223_L	239_V	0.908	0.50
271_A	305_K	0.905	0.50
131_I	175_F	0.903	0.50
251_A	345_I	0.898	0.50
134_I	141_L	0.896	0.49
236_G	281_P	0.894	0.49
117_N	178_G	0.893	0.49
6_I	13_L	0.890	0.49
198_E	340_E	0.887	0.49
133_K	271_A	0.886	0.49
87_K	290_E	0.884	0.48
350_G	354_G	0.879	0.48
348_G	354_G	0.879	0.48
142_G	267_T	0.878	0.48
42_R	139_Y	0.877	0.48
117_N	353_I	0.876	0.48
330_V	355_V	0.874	0.48
338_T	344_V	0.873	0.48
134_I	138_Y	0.872	0.47
85_V	89_E	0.866	0.47
35_L	139_Y	0.864	0.47
278_I	285_K	0.862	0.47
343_T	346_V	0.854	0.46
88_L	242_L	0.851	0.46
133_K	224_K	0.845	0.45
41_M	146_K	0.843	0.45
204_I	242_L	0.839	0.45
138_Y	262_L	0.836	0.45
80_D	286_F	0.834	0.45
79_L	87_K	0.834	0.45
321_D	325_K	0.833	0.44
87_K	281_P	0.821	0.43
187_P	304_I	0.821	0.43
348_G	351_N	0.818	0.43
133_K	305_K	0.817	0.43
124_A	266_K	0.816	0.43
351_N	354_G	0.816	0.43
223_L	347_A	0.816	0.43
204_I	238_A	0.815	0.43
45_A	172_L	0.814	0.43
278_I	349_V	0.814	0.43
284_E	352_T	0.810	0.43
334_I	344_V	0.802	0.42
98_R	125_A	0.802	0.42
252_R	333_I	0.802	0.42
281_P	307_S	0.798	0.42
11_F	21_R	0.797	0.42
218_R	338_T	0.795	0.41
235_P	349_V	0.794	0.41
325_K	329_R	0.794	0.41
327_I	331_K	0.788	0.41
187_P	278_I	0.788	0.41
122_L	302_I	0.786	0.41
250_I	343_T	0.786	0.41
100_K	251_A	0.784	0.41
259_A	305_K	0.783	0.41
120_N	171_A	0.783	0.41
103_V	170_K	0.775	0.40
125_A	230_G	0.771	0.40
310_E	316_R	0.769	0.39
299_L	335_R	0.769	0.39
109_N	133_K	0.768	0.39
172_L	312_I	0.768	0.39
20_Q	132_Y	0.762	0.39
15_F	256_I	0.761	0.39
236_G	286_F	0.759	0.39
21_R	25_Y	0.758	0.39
71_Y	252_R	0.757	0.39
14_F	143_K	0.754	0.38
220_L	334_I	0.750	0.38
132_Y	140_L	0.749	0.38
135_V	154_L	0.745	0.38
120_N	280_G	0.743	0.38
251_A	342_D	0.743	0.38
133_K	355_V	0.743	0.38
236_G	284_E	0.742	0.37
126_M	276_A	0.740	0.37
89_E	236_G	0.738	0.37
80_D	143_K	0.737	0.37
163_E	307_S	0.729	0.37
120_N	286_F	0.727	0.36
223_L	345_I	0.727	0.36
55_K	61_P	0.727	0.36
240_E	256_I	0.726	0.36
240_E	244_E	0.726	0.36
27_M	148_L	0.724	0.36
147_N	352_T	0.723	0.36
96_E	99_F	0.723	0.36
11_F	133_K	0.722	0.36
244_E	294_K	0.721	0.36
86_K	256_I	0.721	0.36
68_F	141_L	0.720	0.36
140_L	264_G	0.717	0.36
2_I	14_F	0.717	0.36
346_V	355_V	0.717	0.36
256_I	331_K	0.716	0.36
123_E	232_V	0.715	0.35
139_Y	179_Q	0.714	0.35
190_A	193_L	0.713	0.35
87_K	285_K	0.712	0.35
101_D	104_K	0.712	0.35
5_L	15_F	0.711	0.35
88_L	285_K	0.711	0.35
226_E	356_G	0.710	0.35
194_M	224_K	0.709	0.35
331_K	355_V	0.709	0.35
131_I	240_E	0.709	0.35
143_K	205_A	0.707	0.35
112_E	324_D	0.707	0.35
31_I	142_G	0.707	0.35
69_L	90_H	0.706	0.35
307_S	310_E	0.701	0.34
224_K	318_E	0.699	0.34
70_E	133_K	0.698	0.34
189_V	256_I	0.698	0.34
193_L	334_I	0.697	0.34
35_L	135_V	0.692	0.34
217_G	270_V	0.692	0.34
5_L	8_I	0.690	0.34
133_K	265_E	0.690	0.34
329_R	332_R	0.686	0.33
35_L	153_Q	0.685	0.33
26_I	151_I	0.684	0.33
5_L	14_F	0.683	0.33
212_E	221_Y	0.683	0.33
44_E	244_E	0.681	0.33
53_I	62_T	0.680	0.33
71_Y	274_V	0.679	0.33
123_E	175_F	0.677	0.33
66_D	339_K	0.676	0.33
29_R	166_E	0.675	0.33
178_G	294_K	0.674	0.33
111_D	335_R	0.673	0.33
9_L	39_K	0.672	0.32
30_E	155_Q	0.671	0.32
132_Y	153_Q	0.670	0.32
124_A	172_L	0.670	0.32
292_A	297_I	0.668	0.32
136_R	262_L	0.667	0.32
95_R	276_A	0.666	0.32
87_K	120_N	0.666	0.32
185_I	306_M	0.665	0.32
252_R	274_V	0.665	0.32
20_Q	149_Y	0.664	0.32
135_V	157_I	0.664	0.32
259_A	303_V	0.664	0.32
44_E	47_K	0.661	0.32
149_Y	152_M	0.660	0.32
121_L	175_F	0.660	0.32
64_R	67_R	0.660	0.32
248_G	295_Y	0.657	0.31
89_E	136_R	0.654	0.31
99_F	234_K	0.652	0.31
187_P	190_A	0.650	0.31
71_Y	164_E	0.650	0.31
27_M	144_K	0.646	0.31
60_D	63_K	0.640	0.30
200_K	212_E	0.638	0.30
20_Q	140_L	0.637	0.30
297_I	326_V	0.636	0.30
28_L	139_Y	0.635	0.30
254_I	302_I	0.635	0.30
181_I	211_A	0.635	0.30
34_S	49_A	0.635	0.30
154_L	321_D	0.634	0.30
175_F	353_I	0.634	0.30
261_K	264_G	0.632	0.30
259_A	270_V	0.630	0.30
68_F	300_Y	0.627	0.29
127_A	130_Q	0.627	0.29
7_W	24_L	0.626	0.29
204_I	346_V	0.625	0.29
9_L	13_L	0.618	0.29
12_I	15_F	0.618	0.29
79_L	286_F	0.618	0.29
5_L	239_V	0.617	0.29
216_E	328_E	0.617	0.29
14_F	22_I	0.616	0.29
143_K	264_G	0.615	0.29
161_I	278_I	0.615	0.29
4_Q	8_I	0.614	0.29
48_E	176_K	0.613	0.28
209_V	217_G	0.613	0.28
173_K	179_Q	0.612	0.28
146_K	160_L	0.611	0.28
143_K	148_L	0.611	0.28
10_F	14_F	0.611	0.28
125_A	346_V	0.608	0.28
27_M	31_I	0.607	0.28
205_A	238_A	0.607	0.28
187_P	355_V	0.607	0.28
109_N	115_V	0.605	0.28
84_I	282_G	0.603	0.28
277_A	301_A	0.602	0.28
10_F	13_L	0.601	0.28
35_L	39_K	0.600	0.28
117_N	158_L	0.600	0.28
112_E	209_V	0.599	0.28
321_D	332_R	0.598	0.28
9_L	22_I	0.597	0.27
241_K	323_V	0.595	0.27
39_K	154_L	0.595	0.27
124_A	127_A	0.594	0.27
140_L	223_L	0.593	0.27
173_K	251_A	0.593	0.27
213_V	331_K	0.592	0.27
173_K	177_K	0.591	0.27
135_V	284_E	0.591	0.27
152_M	322_A	0.590	0.27
3_L	11_F	0.590	0.27
155_Q	280_G	0.590	0.27
50_I	61_P	0.590	0.27
77_V	225_A	0.590	0.27
192_K	323_V	0.588	0.27
107_A	110_A	0.587	0.27
102_E	139_Y	0.586	0.27
93_D	99_F	0.585	0.27
205_A	208_T	0.585	0.27
12_I	21_R	0.585	0.27
215_I	327_I	0.585	0.27
267_T	307_S	0.584	0.27
139_Y	164_E	0.582	0.27
230_G	353_I	0.582	0.27
103_V	206_K	0.582	0.27
267_T	312_I	0.582	0.27
27_M	149_Y	0.581	0.26
118_L	356_G	0.581	0.26
71_Y	139_Y	0.581	0.26
327_I	330_V	0.580	0.26
322_A	343_T	0.580	0.26
163_E	187_P	0.580	0.26
294_K	352_T	0.579	0.26
50_I	65_V	0.579	0.26
19_G	139_Y	0.578	0.26
11_F	299_L	0.578	0.26
159_P	265_E	0.578	0.26
337_R	342_D	0.577	0.26
234_K	287_K	0.576	0.26
87_K	286_F	0.576	0.26
8_I	12_I	0.573	0.26
68_F	99_F	0.572	0.26
26_I	30_E	0.571	0.26
86_K	163_E	0.571	0.26
114_E	310_E	0.571	0.26
117_N	230_G	0.570	0.26
300_Y	309_E	0.570	0.26
330_V	334_I	0.570	0.26
181_I	353_I	0.570	0.26
139_Y	153_Q	0.569	0.26
161_I	188_L	0.569	0.26
98_R	145_T	0.569	0.26
13_L	154_L	0.568	0.26
74_I	276_A	0.568	0.26
302_I	322_A	0.567	0.26
168_Y	234_K	0.565	0.25
166_E	200_K	0.565	0.25
291_V	295_Y	0.565	0.25
77_V	87_K	0.565	0.25
21_R	262_L	0.564	0.25
292_A	325_K	0.564	0.25
224_K	305_K	0.561	0.25
74_I	285_K	0.561	0.25
175_F	259_A	0.560	0.25
260_L	307_S	0.559	0.25
178_G	344_V	0.558	0.25
89_E	145_T	0.556	0.25
45_A	174_A	0.555	0.25
57_G	108_P	0.555	0.25
96_E	119_E	0.555	0.25
95_R	124_A	0.555	0.25
314_P	356_G	0.554	0.25
95_R	175_F	0.554	0.25
270_V	322_A	0.554	0.25
220_L	330_V	0.552	0.25
331_K	335_R	0.551	0.25
254_I	330_V	0.551	0.25
197_K	211_A	0.549	0.25
65_V	109_N	0.548	0.24
188_L	195_L	0.548	0.24
239_V	288_I	0.547	0.24
142_G	151_I	0.547	0.24
12_I	58_K	0.546	0.24
149_Y	232_V	0.546	0.24
127_A	232_V	0.546	0.24
333_I	336_E	0.546	0.24
95_R	119_E	0.544	0.24
133_K	221_Y	0.543	0.24
96_E	239_V	0.542	0.24
39_K	42_R	0.542	0.24
187_P	216_E	0.541	0.24
204_I	356_G	0.541	0.24
307_S	311_A	0.540	0.24
119_E	276_A	0.540	0.24
199_K	256_I	0.540	0.24
308_I	318_E	0.539	0.24
89_E	303_V	0.539	0.24
253_I	259_A	0.537	0.24
65_V	97_D	0.537	0.24
122_L	126_M	0.536	0.24
41_M	266_K	0.535	0.24
187_P	224_K	0.535	0.24
300_Y	337_R	0.534	0.24
90_H	150_L	0.534	0.24
139_Y	300_Y	0.533	0.24
320_A	326_V	0.531	0.24
89_E	276_A	0.531	0.24
44_E	108_P	0.530	0.23
322_A	325_K	0.525	0.23
53_I	61_P	0.524	0.23
147_N	156_M	0.523	0.23
144_K	316_R	0.523	0.23
242_L	262_L	0.523	0.23
84_I	301_A	0.523	0.23
190_A	269_E	0.523	0.23
83_G	143_K	0.522	0.23
16_Y	19_G	0.522	0.23
87_K	282_G	0.519	0.23
348_G	352_T	0.519	0.23
280_G	288_I	0.518	0.23
334_I	338_T	0.518	0.23
107_A	341_G	0.517	0.23
80_D	280_G	0.516	0.23
14_F	191_A	0.515	0.23
190_A	256_I	0.515	0.23
133_K	319_I	0.513	0.23
341_G	346_V	0.513	0.23
35_L	136_R	0.512	0.22
166_E	250_I	0.512	0.22
212_E	245_E	0.512	0.22
108_P	230_G	0.511	0.22
5_L	320_A	0.510	0.22
181_I	236_G	0.510	0.22
32_E	70_E	0.509	0.22
95_R	145_T	0.509	0.22
276_A	349_V	0.508	0.22
74_I	109_N	0.508	0.22
13_L	92_L	0.507	0.22
54_K	92_L	0.507	0.22
17_G	20_Q	0.504	0.22
223_L	285_K	0.502	0.22
271_A	312_I	0.501	0.22
23_Q	123_E	0.501	0.22
187_P	294_K	0.501	0.22
37_K	255_M	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4s12A	2	0.2022	37	0.976	Contact Map
1x92A	4	0.1629	30.3	0.977	Contact Map
3w0lB	1	0.2022	28.3	0.978	Contact Map
2e85A	2	0.382	27.5	0.978	Contact Map
3trjA	4	0.1545	26.6	0.978	Contact Map
2cxcA	1	0.3287	24.8	0.978	Contact Map
4bb9A	1	0.236	20.5	0.979	Contact Map
3pu6A	1	0.3343	19.9	0.979	Contact Map
2i2wA	4	0.1517	19.3	0.979	Contact Map
1c8bA	3	0.6236	15.5	0.98	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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