GREMLIN Database
DUF1501 - Protein of unknown function (DUF1501)
PFAM: PF07394 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 392 (387)
Sequences: 48096 (31159)
Seq/√Len: 1583.9
META: 0.932

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_Q45_W4.3661.00
59_D285_K4.1611.00
337_A347_E3.8011.00
56_L282_T3.6051.00
215_A219_D3.4471.00
24_D27_Y3.0931.00
258_T262_L3.0051.00
28_Y31_R2.8901.00
261_N264_G2.8561.00
278_A282_T2.8031.00
243_E287_R2.7221.00
24_D28_Y2.6331.00
52_H275_Q2.6211.00
13_P18_T2.5491.00
2_K292_D2.5201.00
214_P217_T2.4141.00
263_F267_K2.3771.00
206_E212_K2.3441.00
271_P275_Q2.2721.00
220_L282_T2.2671.00
318_R344_N2.2661.00
298_G322_M2.2281.00
55_K282_T2.2061.00
52_H55_K2.1871.00
242_V249_V2.1821.00
3_R242_V2.1791.00
44_I62_L2.1751.00
319_G338_T2.1751.00
9_L297_W2.1421.00
13_P299_G2.1151.00
335_Y348_D2.1021.00
170_A174_R2.0931.00
253_H256_W2.0801.00
220_L286_Q2.0791.00
56_L281_L2.0771.00
253_H272_E2.0681.00
40_G58_D2.0621.00
5_I280_L2.0591.00
61_A333_Q2.0571.00
266_H270_L2.0501.00
209_D212_K2.0231.00
373_R378_P2.0211.00
219_D223_R2.0191.00
97_S136_Y2.0101.00
337_A346_V1.9991.00
35_K48_E1.9511.00
294_L329_V1.9491.00
57_A60_L1.9201.00
215_A218_R1.9151.00
350_V388_I1.8921.00
273_L297_W1.8871.00
285_K290_L1.8441.00
289_L292_D1.8411.00
330_K333_Q1.8341.00
258_T265_N1.8131.00
46_I57_A1.8101.00
39_T54_A1.8021.00
15_H320_F1.7651.00
258_T269_L1.7591.00
158_S161_R1.7491.00
5_I242_V1.7201.00
277_L325_A1.6691.00
69_D274_D1.6691.00
163_R167_D1.6341.00
44_I334_V1.6171.00
203_S206_E1.6041.00
281_L295_V1.5961.00
66_M274_D1.5851.00
56_L59_D1.5771.00
30_G305_P1.5711.00
377_R383_D1.5691.00
216_A286_Q1.5681.00
264_G268_R1.5581.00
97_S109_A1.5571.00
218_R223_R1.5461.00
167_D170_A1.5461.00
68_T72_N1.5381.00
69_D72_N1.5331.00
282_T286_Q1.5321.00
220_L279_A1.5241.00
36_F45_W1.5061.00
281_L290_L1.4951.00
193_E197_R1.4891.00
44_I57_A1.4691.00
3_R293_T1.4651.00
265_N268_R1.4581.00
277_L297_W1.4511.00
281_L325_A1.4411.00
308_N314_D1.4251.00
277_L323_W1.4171.00
188_R192_Y1.4001.00
288_G291_D1.3971.00
231_F235_C1.3951.00
3_R292_D1.3931.00
64_R334_V1.3911.00
21_P36_F1.3851.00
267_K271_P1.3851.00
117_G120_P1.3801.00
67_H349_P1.3781.00
53_L60_L1.3741.00
26_P29_A1.3721.00
41_Q44_I1.3611.00
66_M322_M1.3551.00
269_L272_E1.3501.00
297_W323_W1.3371.00
110_F114_P1.3281.00
258_T266_H1.3121.00
50_L53_L1.3121.00
55_K58_D1.3071.00
186_E190_A1.3031.00
339_D343_Y1.3021.00
219_D224_D1.2941.00
41_Q57_A1.2911.00
129_S137_Q1.2871.00
290_L327_G1.2801.00
61_A331_G1.2801.00
68_T71_I1.2761.00
40_G55_K1.2731.00
290_L293_T1.2681.00
345_A349_P1.2571.00
84_S89_R1.2461.00
236_L239_R1.2461.00
10_S252_Y1.2451.00
226_P229_G1.2401.00
30_G34_P1.2401.00
202_S206_E1.2401.00
296_V359_I1.2401.00
46_I50_L1.2391.00
335_Y350_V1.2381.00
277_L295_V1.2251.00
261_N265_N1.2201.00
224_D229_G1.2181.00
324_L329_V1.2081.00
354_D385_G1.1951.00
295_V325_A1.1941.00
21_P45_W1.1931.00
53_L277_L1.1921.00
275_Q279_A1.1881.00
148_V151_L1.1841.00
42_S45_W1.1831.00
153_P159_L1.1811.00
63_I324_L1.1751.00
216_A219_D1.1731.00
43_G46_I1.1701.00
268_R271_P1.1681.00
329_V362_L1.1671.00
111_V114_P1.1651.00
282_T285_K1.1641.00
386_K389_K1.1611.00
192_Y195_A1.1541.00
188_R191_S1.1531.00
231_F234_Q1.1451.00
149_L153_P1.1411.00
99_G369_R1.1391.00
190_A193_E1.1341.00
366_D369_R1.1271.00
4_V248_F1.1251.00
273_L277_L1.1251.00
189_I193_E1.1241.00
229_G233_Q1.1221.00
70_L75_P1.1211.00
25_L29_A1.1201.00
217_T220_L1.1191.00
239_R242_V1.1181.00
172_L175_L1.1171.00
73_H76_A1.1151.00
307_I310_N1.1131.00
211_S218_R1.1111.00
171_A174_R1.1091.00
294_L328_G1.1081.00
75_P281_L1.1001.00
116_P119_G1.0971.00
361_H389_K1.0951.00
261_N311_G1.0951.00
368_E386_K1.0941.00
108_P114_P1.0871.00
284_L293_T1.0811.00
6_F298_G1.0751.00
166_L169_L1.0711.00
111_V115_S1.0671.00
61_A329_V1.0651.00
193_E196_F1.0621.00
26_P35_K1.0621.00
18_T50_L1.0611.00
189_I192_Y1.0601.00
296_V324_L1.0591.00
13_P297_W1.0501.00
42_S46_I1.0481.00
238_A242_V1.0441.00
76_A325_A1.0421.00
60_L323_W1.0281.00
237_L240_R1.0271.00
49_L53_L1.0271.00
7_L295_V1.0251.00
200_M204_A1.0171.00
216_A220_L1.0111.00
150_N153_P1.0091.00
19_F78_Y1.0041.00
116_P120_P1.0041.00
6_F296_V1.0011.00
319_G345_A0.9931.00
166_L170_A0.9921.00
57_A62_L0.9911.00
92_L359_I0.9881.00
62_L321_S0.9851.00
27_Y31_R0.9831.00
164_R167_D0.9811.00
206_E244_R0.9781.00
186_E193_E0.9761.00
108_P111_V0.9741.00
207_A244_R0.9721.00
281_L284_L0.9711.00
44_I64_R0.9601.00
169_L173_N0.9571.00
374_H379_F0.9571.00
53_L56_L0.9561.00
52_H278_A0.9501.00
66_M355_L0.9491.00
52_H56_L0.9481.00
280_L284_L0.9441.00
266_H269_L0.9411.00
174_R177_L0.9411.00
177_L186_E0.9411.00
39_T46_I0.9401.00
122_G125_R0.9351.00
284_L290_L0.9341.00
324_L355_L0.9291.00
353_H384_H0.9281.00
264_G267_K0.9271.00
160_E163_R0.9251.00
192_Y196_F0.9231.00
221_Y224_D0.9211.00
40_G57_A0.9201.00
265_N269_L0.9181.00
281_L285_K0.9181.00
118_G121_G0.9181.00
191_S194_L0.9161.00
294_L324_L0.9161.00
72_N75_P0.9121.00
176_H179_R0.9101.00
70_L85_P0.9041.00
23_P59_D0.9011.00
171_A175_L0.9011.00
238_A241_L0.8971.00
209_D213_E0.8921.00
231_F277_L0.8881.00
223_R233_Q0.8871.00
39_T42_S0.8871.00
215_A223_R0.8841.00
21_P64_R0.8841.00
191_S195_A0.8831.00
221_Y225_A0.8801.00
63_I350_V0.8791.00
89_R131_F0.8781.00
272_E276_A0.8761.00
129_S134_R0.8701.00
194_L197_R0.8691.00
26_P30_G0.8671.00
307_I311_G0.8641.00
25_L28_Y0.8631.00
35_K39_T0.8611.00
163_R166_L0.8611.00
149_L152_S0.8581.00
77_A81_N0.8501.00
253_H269_L0.8491.00
9_L273_L0.8441.00
218_R233_Q0.8421.00
183_P186_E0.8411.00
144_G147_P0.8391.00
184_E188_R0.8371.00
173_N177_L0.8351.00
133_G137_Q0.8321.00
76_A80_M0.8311.00
13_P266_H0.8291.00
153_P156_G0.8271.00
356_H359_I0.8231.00
204_A208_F0.8231.00
224_D228_T0.8211.00
120_P123_G0.8211.00
48_E51_P0.8191.00
76_A81_N0.8191.00
222_G225_A0.8191.00
235_C251_V0.8181.00
108_P112_V0.8181.00
14_S258_T0.8181.00
47_S50_L0.8141.00
93_G106_N0.8121.00
262_L266_H0.8111.00
290_L295_V0.8101.00
95_W107_L0.8081.00
202_S205_P0.8071.00
92_L356_H0.8061.00
46_I49_L0.8061.00
190_A194_L0.8031.00
162_Q165_R0.8011.00
10_S77_A0.7991.00
28_Y341_L0.7971.00
329_V333_Q0.7931.00
8_F77_A0.7931.00
52_H282_T0.7911.00
109_A112_V0.7891.00
218_R221_Y0.7881.00
240_R244_R0.7881.00
172_L176_H0.7861.00
63_I66_M0.7841.00
56_L60_L0.7811.00
268_R272_E0.7811.00
165_R168_L0.7801.00
67_H351_H0.7801.00
16_L342_G0.7781.00
70_L76_A0.7761.00
15_H18_T0.7751.00
46_I53_L0.7731.00
108_P113_L0.7711.00
253_H273_L0.7701.00
110_F115_S0.7691.00
44_I47_S0.7691.00
159_L163_R0.7681.00
263_F266_H0.7681.00
18_T270_L0.7671.00
110_F113_L0.7661.00
165_R169_L0.7641.00
173_N176_H0.7631.00
80_M320_F0.7631.00
227_K230_S0.7631.00
39_T44_I0.7621.00
175_L178_R0.7601.00
379_F383_D0.7561.00
50_L54_A0.7541.00
161_R165_R0.7531.00
107_L111_V0.7521.00
277_L281_L0.7511.00
214_P221_Y0.7501.00
69_D278_A0.7491.00
69_D275_Q0.7481.00
236_L240_R0.7451.00
223_R229_G0.7431.00
218_R225_A0.7421.00
143_S146_D0.7421.00
153_P161_R0.7411.00
215_A221_Y0.7371.00
225_A275_Q0.7361.00
232_G251_V0.7351.00
236_L241_L0.7341.00
206_E209_D0.7331.00
112_V115_S0.7321.00
291_D327_G0.7291.00
68_T79_V0.7281.00
23_P26_P0.7281.00
19_F62_L0.7241.00
322_M355_L0.7221.00
119_G123_G0.7221.00
107_L110_F0.7211.00
96_V363_L0.7191.00
121_G125_R0.7191.00
106_N203_S0.7171.00
211_S215_A0.7151.00
219_D222_G0.7151.00
74_G77_A0.7141.00
372_Y376_G0.7131.00
109_A113_L0.7121.00
129_S133_G0.7121.00
149_L154_P0.7111.00
66_M320_F0.7101.00
18_T266_H0.7091.00
65_S348_D0.7081.00
93_G110_F0.7081.00
15_H321_S0.7081.00
4_V363_L0.7041.00
210_L218_R0.7031.00
201_Q205_P0.7031.00
65_S267_K0.7021.00
377_R385_G0.7001.00
98_Y102_S0.6991.00
38_Q42_S0.6991.00
207_A210_L0.6981.00
218_R222_G0.6971.00
119_G122_G0.6971.00
152_S155_A0.6971.00
17_D20_D0.6941.00
91_S94_S0.6921.00
50_L270_L0.6901.00
27_Y30_G0.6891.00
182_D186_E0.6881.00
233_Q236_L0.6871.00
54_A57_A0.6861.00
169_L172_L0.6851.00
373_R379_F0.6841.00
232_G236_L0.6831.00
4_V296_V0.6791.00
211_S214_P0.6791.00
37_I54_A0.6731.00
180_P185_L0.6721.00
134_R187_A0.6691.00
201_Q204_A0.6691.00
234_Q238_A0.6691.00
237_L241_L0.6671.00
74_G80_M0.6631.00
67_H345_A0.6631.00
236_L242_V0.6621.00
210_L213_E0.6611.00
213_E221_Y0.6601.00
162_Q166_L0.6581.00
232_G235_C0.6551.00
351_H354_D0.6511.00
153_P158_S0.6511.00
111_V246_V0.6481.00
59_D282_T0.6471.00
167_D171_A0.6451.00
184_E187_A0.6451.00
105_Q109_A0.6441.00
205_P209_D0.6441.00
117_G123_G0.6431.00
21_P47_S0.6431.00
231_F276_A0.6411.00
346_V349_P0.6411.00
65_S271_P0.6401.00
48_E52_H0.6391.00
267_K270_L0.6381.00
92_L96_V0.6381.00
189_I196_F0.6351.00
100_L103_E0.6341.00
316_W344_N0.6341.00
45_W64_R0.6341.00
151_L154_P0.6331.00
46_I62_L0.6331.00
21_P26_P0.6321.00
185_L189_I0.6311.00
355_L359_I0.6281.00
45_W48_E0.6281.00
188_R195_A0.6281.00
102_S105_Q0.6281.00
117_G121_G0.6251.00
306_K343_Y0.6231.00
160_E165_R0.6211.00
344_N349_P0.6201.00
79_V85_P0.6201.00
150_N154_P0.6181.00
47_S51_P0.6171.00
19_F321_S0.6171.00
25_L30_G0.6161.00
48_E267_K0.6151.00
242_V289_L0.6151.00
79_V324_L0.6121.00
301_F317_P0.6121.00
338_T346_V0.6111.00
38_Q41_Q0.6111.00
213_E218_R0.6091.00
121_G124_A0.6071.00
148_V153_P0.6071.00
107_L113_L0.6071.00
208_F214_P0.6071.00
214_P218_R0.6061.00
71_I317_P0.6041.00
260_G310_N0.6041.00
370_L380_R0.6041.00
340_E346_V0.6031.00
96_V100_L0.6031.00
31_R34_P0.6021.00
308_N311_G0.6011.00
9_L253_H0.5991.00
353_H383_D0.5991.00
7_L297_W0.5981.00
157_V161_R0.5971.00
119_G124_A0.5971.00
160_E164_R0.5941.00
78_Y82_T0.5941.00
183_P187_A0.5931.00
123_G126_N0.5911.00
281_L323_W0.5891.00
5_I284_L0.5891.00
243_E289_L0.5871.00
204_A207_A0.5861.00
367_H382_T0.5851.00
176_H180_P0.5851.00
40_G44_I0.5851.00
95_W99_G0.5851.00
149_L155_A0.5841.00
233_Q237_L0.5831.00
368_E380_R0.5811.00
26_P342_G0.5801.00
77_A335_Y0.5801.00
372_Y379_F0.5791.00
97_S101_G0.5781.00
106_N109_A0.5771.00
81_N250_Q0.5761.00
50_L273_L0.5761.00
274_D278_A0.5751.00
166_L196_F0.5741.00
316_W319_G0.5741.00
49_L267_K0.5741.00
356_H360_L0.5731.00
294_L359_I0.5721.00
100_L247_R0.5721.00
256_W273_L0.5681.00
213_E217_T0.5661.00
155_A158_S0.5661.00
177_L180_P0.5651.00
210_L214_P0.5641.00
316_W345_A0.5631.00
168_L172_L0.5611.00
235_C276_A0.5601.00
69_D85_P0.5591.00
181_G184_E0.5581.00
105_Q108_P0.5571.00
80_M334_V0.5561.00
235_C238_A0.5561.00
154_P157_V0.5561.00
47_S52_H0.5561.00
170_A173_N0.5551.00
284_L287_R0.5551.00
72_N278_A0.5531.00
39_T45_W0.5531.00
223_R227_K0.5511.00
180_P183_P0.5501.00
116_P121_G0.5501.00
263_F311_G0.5491.00
123_G127_W0.5491.00
19_F53_L0.5481.00
240_R243_E0.5481.00
284_L289_L0.5451.00
150_N156_G0.5441.00
352_V355_L0.5431.00
74_G78_Y0.5411.00
234_Q251_V0.5401.00
285_K331_G0.5391.00
262_L267_K0.5391.00
199_L204_A0.5381.00
235_C239_R0.5361.00
326_G329_V0.5361.00
290_L325_A0.5361.00
28_Y32_P0.5361.00
203_S207_A0.5351.00
65_S345_A0.5351.00
34_P42_S0.5341.00
3_R289_L0.5321.00
56_L285_K0.5321.00
156_G159_L0.5311.00
185_L188_R0.5281.00
76_A82_T0.5281.00
92_L248_F0.5271.00
56_L278_A0.5271.00
210_L217_T0.5261.00
153_P162_Q0.5251.00
185_L192_Y0.5241.00
81_N252_Y0.5231.00
279_A283_D0.5221.00
109_A114_P0.5221.00
199_L203_S0.5211.00
148_V152_S0.5201.00
89_R379_F0.5191.00
46_I54_A0.5191.00
143_S147_P0.5191.00
294_L362_L0.5181.00
19_F323_W0.5181.00
231_F236_L0.5171.00
182_D185_L0.5171.00
380_R383_D0.5171.00
188_R193_E0.5161.00
221_Y283_D0.5151.00
207_A211_S0.5151.00
187_A190_A0.5151.00
96_V248_F0.5141.00
53_L323_W0.5131.00
164_R168_L0.5131.00
210_L221_Y0.5121.00
77_A80_M0.5091.00
237_L242_V0.5081.00
157_V160_E0.5061.00
49_L52_H0.5051.00
134_R137_Q0.5041.00
260_G265_N0.5041.00
281_L327_G0.5031.00
37_I48_E0.5021.00
283_D287_R0.5021.00
187_A191_S0.5021.00
156_G161_R0.5011.00
161_R164_R0.5011.00
174_R178_R0.5001.00
3_R249_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nkqA 1 0.6556 90.9 0.933 Contact Map
4lr2A 1 0.6862 89.4 0.935 Contact Map
2gsoA 1 0.6837 77.2 0.944 Contact Map
3b5qA 1 0.648 73.2 0.946 Contact Map
1p49A 3 0.6173 64.6 0.949 Contact Map
1aukA 3 0.7398 62.5 0.95 Contact Map
2qzuA 2 0.6327 51.8 0.953 Contact Map
4upkA 3 0.6735 51.4 0.953 Contact Map
1fsuA 1 0.6403 47.2 0.954 Contact Map
4kavA 1 0.6735 41.7 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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