GREMLIN Database
DUF1499 - Protein of unknown function (DUF1499)
PFAM: PF07386 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 114 (113)
Sequences: 15031 (11036)
Seq/√Len: 1038.2
META: 0.917

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_T72_V3.3771.00
89_V107_I2.5311.00
41_L45_R2.4771.00
74_D94_R2.4631.00
41_L55_P2.3131.00
59_Y76_E2.2041.00
64_A75_V1.9281.00
32_P35_E1.9281.00
5_D11_C1.9211.00
79_V85_S1.9201.00
31_G36_A1.8171.00
43_A47_M1.8081.00
47_M113_A1.8041.00
65_T72_V1.7741.00
37_F79_V1.7591.00
37_F41_L1.7501.00
80_D88_D1.7321.00
27_L111_R1.7231.00
102_V105_K1.6811.00
15_Q18_A1.6721.00
44_A49_W1.6471.00
26_P86_R1.5321.00
13_S16_A1.5131.00
31_G35_E1.5021.00
19_A22_P1.4461.00
44_A62_A1.4361.00
31_G39_R1.3981.00
66_T102_V1.3901.00
80_D83_G1.3771.00
23_D108_E1.3661.00
15_Q78_R1.3531.00
8_S97_R1.3441.00
54_D57_D1.3431.00
47_M109_A1.3351.00
28_R86_R1.3211.00
73_D106_R1.2981.00
40_A110_F1.2791.00
29_L36_A1.2691.00
61_E76_E1.2621.00
66_T69_F1.2461.00
40_A77_I1.2311.00
14_S18_A1.2111.00
62_A75_V1.1791.00
35_E39_R1.1761.00
46_A113_A1.1691.00
24_I107_I1.1641.00
36_A87_I1.1641.00
78_R88_D1.1511.00
47_M64_A1.1491.00
89_V111_R1.1451.00
77_I89_V1.1361.00
33_P81_P1.1181.00
38_A55_P1.1121.00
73_D102_V1.1091.00
104_A108_E1.0781.00
28_R82_D1.0781.00
109_A113_A1.0771.00
65_T70_G1.0751.00
20_A23_D1.0741.00
38_A42_A1.0521.00
75_V110_F1.0441.00
36_A79_V1.0431.00
41_L60_I1.0321.00
37_F58_G1.0081.00
33_P37_F1.0021.00
64_A106_R0.9941.00
33_P79_V0.9941.00
38_A41_L0.9881.00
101_G105_K0.9781.00
8_S80_D0.9581.00
29_L114_L0.9521.00
91_S106_R0.9491.00
37_F60_I0.9451.00
15_Q88_D0.9341.00
24_I89_V0.9331.00
8_S11_C0.9301.00
91_S103_N0.9061.00
49_W110_F0.9021.00
35_E38_A0.8951.00
13_S17_A0.8861.00
80_D86_R0.8851.00
3_T10_N0.8801.00
3_T6_P0.8751.00
14_S17_A0.8701.00
44_A110_F0.8611.00
39_R43_A0.8571.00
92_A97_R0.8451.00
42_A45_R0.8391.00
40_A79_V0.8381.00
82_D86_R0.8371.00
42_A46_A0.8331.00
60_I77_I0.8301.00
102_V106_R0.8181.00
49_W75_V0.8141.00
51_I62_A0.7991.00
43_A110_F0.7761.00
76_E90_R0.7701.00
36_A85_S0.7681.00
47_M110_F0.7591.00
58_G78_R0.7571.00
43_A113_A0.7551.00
72_V95_V0.7511.00
24_I108_E0.7501.00
44_A51_I0.7411.00
33_P36_A0.7371.00
12_V15_Q0.7331.00
66_T71_F0.7201.00
36_A114_L0.7181.00
108_E111_R0.7181.00
50_E63_T0.7111.00
25_A28_R0.7031.00
58_G81_P0.7011.00
54_D61_E0.6961.00
32_P36_A0.6951.00
11_C14_S0.6911.00
61_E74_D0.6891.00
95_V98_S0.6801.00
44_A77_I0.6781.00
10_N92_A0.6671.00
83_G86_R0.6671.00
98_S101_G0.6651.00
34_A38_A0.6631.00
24_I104_A0.6621.00
98_S105_K0.6581.00
6_P10_N0.6571.00
29_L79_V0.6561.00
50_E65_T0.6521.00
33_P58_G0.6431.00
66_T73_D0.6431.00
81_P84_G0.6421.00
6_P11_C0.6421.00
9_P97_R0.6411.00
4_T16_A0.6381.00
50_E72_V0.6341.00
40_A44_A0.6221.00
37_F55_P0.6211.00
75_V93_S0.6111.00
93_S103_N0.6101.00
21_Y104_A0.6031.00
80_D84_G0.6001.00
39_R42_A0.5911.00
77_I87_I0.5891.00
41_L53_V0.5881.00
12_V16_A0.5831.00
2_L15_Q0.5821.00
26_P88_D0.5781.00
73_D103_N0.5761.00
44_A64_A0.5711.00
33_P85_S0.5691.00
44_A60_I0.5621.00
66_T70_G0.5581.00
13_S57_D0.5491.00
75_V107_I0.5491.00
105_K109_A0.5491.00
37_F53_V0.5481.00
71_F96_G0.5441.00
49_W64_A0.5431.00
30_A36_A0.5351.00
64_A102_V0.5331.00
40_A43_A0.5301.00
37_F57_D0.5261.00
66_T96_G0.5251.00
9_P12_V0.5241.00
11_C16_A0.5201.00
59_Y78_R0.5131.00
93_S102_V0.5121.00
17_A20_A0.5121.00
73_D91_S0.5071.00
89_V110_F0.5021.00
83_G88_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ywtA 1 0.7982 22.1 0.894 Contact Map
3odnA 1 0.7193 20.7 0.896 Contact Map
1eswA 1 0.3333 19.3 0.898 Contact Map
2yh5A 1 0.9035 18.6 0.898 Contact Map
3tgoC 2 0 13.4 0.904 Contact Map
2inbA 2 0.5526 8.6 0.912 Contact Map
1tz7A 4 0.3333 7.6 0.914 Contact Map
2zq5A 1 0.3246 6.2 0.918 Contact Map
3aqtA 2 0.7719 5.7 0.919 Contact Map
1x1nA 2 0.5088 4.3 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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