GREMLIN Database
HC2 - Histone H1-like nucleoprotein HC2
PFAM: PF07382 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 194 (169)
Sequences: 1150 (983)
Seq/√Len: 75.6
META: 0.702

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_K61_A4.1021.00
174_A177_A3.2111.00
167_A173_A2.7561.00
53_A56_A2.7201.00
173_A176_T2.4291.00
84_A94_A2.4281.00
99_A109_A2.4281.00
144_K147_A2.2291.00
109_A112_K2.2181.00
71_A101_A2.1761.00
75_A95_A2.0311.00
175_K179_N1.9431.00
176_T179_N1.9421.00
94_A104_A1.9361.00
151_K156_K1.8991.00
100_A110_A1.8801.00
38_A69_A1.8481.00
69_A99_A1.8161.00
56_A61_A1.7981.00
150_K155_K1.7671.00
79_A89_A1.7621.00
168_A173_A1.6871.00
115_A125_A1.6861.00
79_A109_A1.6621.00
65_A95_A1.6521.00
120_A130_A1.6221.00
71_A86_A1.6021.00
160_K165_A1.5970.99
173_A177_A1.5900.99
32_K47_K1.5840.99
95_A105_A1.5590.99
87_K97_K1.5570.99
79_A99_A1.5240.99
64_A74_A1.5240.99
79_A82_K1.5110.99
94_A109_A1.4980.99
125_A135_A1.4760.99
28_A89_A1.4760.99
89_A109_A1.4580.99
53_A74_A1.4490.99
28_A38_A1.4480.99
80_A100_A1.4430.99
138_K143_K1.4230.99
107_K112_K1.4230.99
26_K46_K1.3980.99
168_A172_P1.3830.99
155_K160_K1.3660.98
43_A84_A1.3370.98
48_A79_A1.3200.98
69_A89_A1.3040.98
91_A101_A1.3040.98
36_K46_K1.3020.98
116_A120_A1.2740.97
64_A94_A1.2710.97
87_K92_K1.2670.97
81_A96_A1.2570.97
96_A106_A1.2550.97
88_K98_K1.2550.97
73_K93_K1.2410.97
58_K63_K1.2410.97
51_K56_A1.2300.97
35_A45_A1.2280.97
71_A91_A1.2240.97
156_K161_K1.1970.96
77_K87_K1.1950.96
13_A23_A1.1900.96
70_A100_A1.1870.96
72_K82_K1.1630.96
77_K97_K1.1590.96
89_A104_A1.1470.95
127_A137_A1.1420.95
20_A23_A1.1370.95
11_K16_K1.1320.95
100_A105_A1.1160.95
24_A34_A1.1080.94
83_K93_K1.0980.94
174_A179_N1.0910.94
37_K47_K1.0870.94
26_K41_K1.0760.93
101_A111_A1.0750.93
123_K133_K1.0610.93
121_A131_A1.0600.93
133_K138_K1.0540.93
85_A116_A1.0450.92
165_A177_A1.0440.92
22_K27_K1.0380.92
86_A101_A1.0240.92
33_A43_A1.0170.91
41_K72_K1.0120.91
74_A94_A0.9990.91
12_K22_K0.9980.90
86_A117_A0.9940.90
70_A90_A0.9900.90
60_A64_A0.9830.90
44_A75_A0.9810.90
43_A53_A0.9750.89
82_K102_K0.9750.89
105_A110_A0.9750.89
84_A104_A0.9600.89
131_A141_A0.9590.89
30_A40_A0.9550.88
92_K102_K0.9550.88
169_A178_L0.9540.88
26_K31_K0.9530.88
63_K66_A0.9520.88
116_A121_A0.9500.88
175_K178_L0.9470.88
89_A99_A0.9390.88
41_K92_K0.9340.87
104_A115_A0.9250.87
168_A176_T0.9250.87
17_K32_K0.9090.86
74_A84_A0.9060.86
26_K36_K0.9030.85
38_A48_A0.9010.85
161_K166_P0.8930.85
73_K88_K0.8890.85
35_A66_A0.8880.85
161_K165_A0.8800.84
156_K159_P0.8770.84
98_K108_K0.8740.84
102_K123_K0.8740.84
94_A115_A0.8710.83
94_A125_A0.8650.83
70_A74_A0.8590.83
82_K92_K0.8510.82
78_K108_K0.8500.82
173_A179_N0.8400.81
147_A150_K0.8370.81
170_A179_N0.8340.81
22_K37_K0.8280.80
43_A64_A0.8280.80
89_A120_A0.8230.80
45_A96_A0.8180.79
43_A74_A0.8080.78
47_K52_K0.8070.78
169_A173_A0.8050.78
77_K92_K0.8030.78
43_A69_A0.8010.78
141_A158_A0.7990.78
37_K78_K0.7980.78
68_K98_K0.7940.77
81_A111_A0.7930.77
92_K107_K0.7930.77
42_K73_K0.7740.75
105_A116_A0.7740.75
45_A55_A0.7700.75
85_A105_A0.7640.75
85_A95_A0.7640.75
97_K107_K0.7630.74
77_K107_K0.7620.74
165_A169_A0.7600.74
63_K83_K0.7580.74
14_A24_A0.7550.74
65_A85_A0.7530.73
128_K138_K0.7460.73
75_A85_A0.7430.72
170_A173_A0.7410.72
31_K67_K0.7410.72
167_A172_P0.7300.71
19_A29_A0.7300.71
71_A81_A0.7280.71
104_A125_A0.7200.70
69_A84_A0.7190.70
31_K41_K0.7110.69
108_K113_K0.7050.68
110_A121_A0.7040.68
82_K97_K0.6960.67
12_K27_K0.6880.67
67_K72_K0.6870.66
134_K137_A0.6850.66
165_A168_A0.6840.66
73_K83_K0.6810.66
172_P177_A0.6780.65
53_A64_A0.6770.65
95_A126_A0.6760.65
46_K97_K0.6740.65
41_K102_K0.6710.65
32_K93_K0.6690.64
168_A174_A0.6680.64
84_A99_A0.6680.64
69_A79_A0.6660.64
76_A96_A0.6660.64
22_K32_K0.6600.63
21_K46_K0.6590.63
81_A101_A0.6570.63
90_A110_A0.6570.63
94_A99_A0.6560.63
48_A51_K0.6560.63
124_K134_K0.6540.63
83_K103_K0.6540.63
22_K83_K0.6540.63
117_A137_A0.6500.62
68_K119_K0.6480.62
47_K78_K0.6440.61
104_A109_A0.6440.61
34_A38_A0.6400.61
75_A105_A0.6390.61
89_A140_A0.6380.61
72_K97_K0.6340.60
52_K57_K0.6280.60
78_K83_K0.6250.59
119_K129_K0.6230.59
22_K129_K0.6160.58
36_K77_K0.6150.58
40_A76_A0.6130.58
155_K159_P0.6110.57
68_K78_K0.6090.57
80_A90_A0.6060.57
124_K129_K0.6040.57
42_K98_K0.6020.56
162_P172_P0.6020.56
63_K68_K0.6010.56
40_A71_A0.5950.55
83_K98_K0.5890.55
41_K51_K0.5850.54
99_A120_A0.5850.54
159_P162_P0.5750.53
128_K133_K0.5700.52
65_A75_A0.5700.52
159_P163_A0.5670.52
54_A65_A0.5590.51
84_A115_A0.5580.51
66_A91_A0.5520.50
43_A104_A0.5510.50
119_K124_K0.5500.50
35_A50_A0.5500.50
45_A86_A0.5490.50
46_K72_K0.5460.49
75_A79_A0.5440.49
16_K21_K0.5440.49
29_A80_A0.5400.49
118_K138_K0.5380.48
74_A104_A0.5350.48
53_A58_K0.5350.48
63_K73_K0.5350.48
131_A135_A0.5320.48
104_A140_A0.5280.47
91_A122_A0.5260.47
90_A94_A0.5240.47
171_A174_A0.5240.47
78_K88_K0.5230.46
46_K51_K0.5200.46
166_P171_A0.5140.45
117_A120_A0.5140.45
14_A29_A0.5130.45
32_K42_K0.5120.45
21_K82_K0.5120.45
141_A153_A0.5110.45
172_P175_K0.5080.45
44_A85_A0.5070.44
72_K102_K0.5040.44
154_A159_P0.5020.44
96_A111_A0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tjlA 2 0.2629 10.1 0.919 Contact Map
1useA 3 0.1031 9.2 0.92 Contact Map
1x4tA 1 0.201 8.4 0.922 Contact Map
4tq1B 1 0.0773 3.4 0.935 Contact Map
2jm6A 1 0.1392 2.6 0.939 Contact Map
4g35B 1 0.0876 2.5 0.939 Contact Map
2dgzA 1 0.2113 1.5 0.947 Contact Map
1ydiB 1 0.0619 1.4 0.947 Contact Map
1wudA 3 0.1186 1.4 0.947 Contact Map
4w20M 1 0.134 1.1 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.007 seconds.