GREMLIN Database
DUF1489 - Protein of unknown function (DUF1489)
PFAM: PF07370 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 139 (137)
Sequences: 4862 (2723)
Seq/√Len: 232.6
META: 0.893

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_R85_D3.2661.00
8_C13_D3.0821.00
5_C8_C3.0441.00
8_C17_W2.7721.00
61_A88_L2.7541.00
68_L82_I2.7391.00
41_R44_E2.6361.00
65_I82_I2.6361.00
13_D17_W2.3591.00
5_C51_L2.3471.00
34_V81_A2.3391.00
1_L45_L2.3371.00
2_I59_I2.3261.00
45_L65_I2.3021.00
67_G83_V2.1621.00
73_D79_R2.1061.00
32_R81_A2.1001.00
15_A90_P2.0881.00
91_V94_R2.0871.00
92_E112_P2.0101.00
54_V99_F1.9761.00
58_Q93_P1.9131.00
106_E109_D1.8831.00
38_T70_E1.8651.00
15_A88_L1.7511.00
71_V81_A1.7271.00
105_L110_A1.6191.00
9_D13_D1.6161.00
69_E83_V1.5971.00
11_V61_A1.5541.00
30_E69_E1.5231.00
132_E135_E1.5171.00
70_E78_G1.4851.00
18_Q31_L1.4831.00
71_V79_R1.4661.00
11_V90_P1.4591.00
41_R106_E1.3861.00
38_T42_A1.3171.00
4_L99_F1.2791.00
12_E16_A1.2691.00
10_S13_D1.2661.00
21_E25_R1.2611.00
127_P131_R1.2561.00
42_A67_G1.2491.00
60_L93_P1.2111.00
96_R109_D1.1901.00
30_E83_V1.1581.00
12_E15_A1.1561.00
4_L54_V1.1521.00
22_A27_E1.1521.00
115_G118_A1.1091.00
125_L129_L1.1081.00
9_D56_K1.0971.00
107_P110_A1.0971.00
45_L68_L1.0951.00
5_C17_W1.0931.00
72_T78_G1.0931.00
73_D77_I1.0821.00
5_C13_D1.0801.00
42_A68_L1.0701.00
59_I94_R1.0571.00
42_A46_L1.0391.00
69_E81_A1.0191.00
15_A18_Q1.0001.00
73_D78_G0.9911.00
8_C14_L0.9861.00
125_L130_R0.9761.00
11_V55_I0.9591.00
1_L82_I0.9431.00
132_E138_L0.9271.00
132_E136_L0.9261.00
38_T78_G0.9201.00
130_R134_A0.9081.00
10_S55_I0.9081.00
20_A24_R0.8890.99
62_R113_D0.8880.99
5_C14_L0.8860.99
34_V71_V0.8840.99
66_L85_D0.8820.99
38_T68_L0.8810.99
22_A29_G0.8760.99
33_H82_I0.8750.99
33_H84_L0.8700.99
64_R87_E0.8650.99
8_C55_I0.8500.99
128_E131_R0.8490.99
30_E67_G0.8480.99
55_I60_L0.8470.99
75_D79_R0.8230.99
22_A28_P0.8100.99
38_T80_C0.8040.99
46_L67_G0.7990.99
117_G120_G0.7980.99
63_Q88_L0.7950.99
127_P130_R0.7910.99
95_P98_A0.7890.99
2_I96_R0.7860.99
5_C10_S0.7860.99
26_G29_G0.7750.98
34_V79_R0.7700.98
32_R83_V0.7690.98
63_Q84_L0.7680.98
118_A121_G0.7680.98
3_K33_H0.7680.98
59_I91_V0.7630.98
50_S62_R0.7620.98
45_L49_G0.7570.98
25_R29_G0.7550.98
33_H83_V0.7500.98
128_E132_E0.7500.98
37_M99_F0.7480.98
130_R139_L0.7280.98
63_Q86_P0.7250.98
119_A123_A0.7220.98
129_L132_E0.7220.98
128_E135_E0.7210.98
23_R27_E0.7100.97
45_L107_P0.7050.97
40_K106_E0.7020.97
5_C55_I0.7000.97
32_R71_V0.6980.97
23_R29_G0.6970.97
20_A23_R0.6960.97
43_D47_D0.6900.97
60_L94_R0.6890.97
131_R135_E0.6880.97
68_L80_C0.6840.97
134_A138_L0.6820.97
13_D16_A0.6800.97
31_L86_P0.6780.96
2_I99_F0.6760.96
33_H53_W0.6750.96
4_L9_D0.6740.96
21_E29_G0.6710.96
55_I61_A0.6710.96
22_A26_G0.6690.96
20_A27_E0.6680.96
50_S113_D0.6660.96
21_E24_R0.6580.96
92_E118_A0.6580.96
18_Q86_P0.6580.96
70_E81_A0.6570.96
34_V77_I0.6530.96
37_M40_K0.6490.95
32_R69_E0.6490.95
2_I91_V0.6480.95
46_L68_L0.6470.95
8_C51_L0.6450.95
31_L84_L0.6400.95
10_S16_A0.6390.95
37_M68_L0.6390.95
120_G123_A0.6340.95
5_C53_W0.6340.95
36_R65_I0.6280.95
31_L85_D0.6240.94
21_E27_E0.6210.94
132_E137_G0.6140.94
22_A25_R0.6110.94
37_M73_D0.6100.94
33_H51_L0.6090.94
4_L37_M0.6070.94
129_L138_L0.6060.94
58_Q131_R0.6060.94
93_P114_L0.6040.93
66_L84_L0.6020.93
59_I96_R0.6010.93
4_L7_G0.5970.93
59_I105_L0.5970.93
46_L65_I0.5920.93
45_L48_G0.5890.93
24_R29_G0.5890.93
58_Q127_P0.5870.92
116_A120_G0.5790.92
116_A119_A0.5780.92
68_L71_V0.5760.92
56_K98_A0.5750.92
50_S63_Q0.5730.92
1_L65_I0.5690.91
53_W61_A0.5660.91
73_D81_A0.5640.91
18_Q84_L0.5590.91
57_G99_F0.5550.90
27_E30_E0.5540.90
51_L82_I0.5540.90
11_V14_L0.5510.90
37_M79_R0.5460.89
119_A127_P0.5460.89
85_D89_V0.5450.89
128_E137_G0.5440.89
37_M42_A0.5420.89
30_E66_L0.5360.89
64_R89_V0.5340.88
14_L55_I0.5320.88
37_M78_G0.5280.88
96_R105_L0.5270.88
18_Q63_Q0.5150.87
6_V55_I0.5150.87
94_R112_P0.5150.87
5_C61_A0.5150.87
71_V77_I0.5130.86
130_R135_E0.5090.86
33_H86_P0.5050.86
121_G124_A0.5040.85
115_G119_A0.5030.85
65_I68_L0.5020.85
133_L136_L0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mk9A 2 0.2302 10.6 0.954 Contact Map
2jd3A 2 0.2878 9.8 0.954 Contact Map
2rodB 1 0.1223 9.4 0.955 Contact Map
5af7A 4 0.3453 9.3 0.955 Contact Map
4xvxA 4 0.3237 8.4 0.956 Contact Map
1ivhA 4 0.3885 8.2 0.956 Contact Map
1vr3A 1 0.2662 7.7 0.957 Contact Map
1ukwA 4 0.3669 7.3 0.957 Contact Map
3m9vA 4 0.3885 7.1 0.957 Contact Map
4x28D 2 0.3813 6.8 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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