GREMLIN Database
Glyco_hydro_75 - Fungal chitosanase of glycosyl hydrolase group 75
PFAM: PF07335 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 163 (135)
Sequences: 1282 (872)
Seq/√Len: 75.1
META: 0.739

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_L83_G6.2531.00
97_A101_L5.4921.00
80_A101_L4.0171.00
24_Q28_R3.5441.00
26_S85_T2.9141.00
51_G85_T2.6151.00
110_P115_R2.6121.00
117_G121_G2.5961.00
1_M124_Y2.3061.00
47_I69_Y2.2801.00
112_D115_R2.1401.00
97_A124_Y2.0901.00
118_S121_G1.9811.00
28_R38_D1.9691.00
113_P116_G1.8511.00
3_I102_A1.7821.00
70_A80_A1.7711.00
17_T20_D1.7631.00
49_L82_V1.7581.00
49_L126_V1.7511.00
22_Q25_T1.7061.00
100_A104_A1.6621.00
69_Y126_V1.6471.00
78_Y104_A1.6461.00
8_S40_D1.6131.00
107_G113_P1.5930.99
63_I126_V1.5710.99
71_V101_L1.5050.99
111_P115_R1.4530.99
14_G42_E1.4360.99
16_G19_P1.4300.99
10_G42_E1.4040.99
5_C15_C1.3760.98
18_D21_F1.3680.98
78_Y101_L1.3520.98
82_V126_V1.3470.98
27_F65_G1.3370.98
40_D43_T1.3260.98
63_I82_V1.3230.98
70_A79_Y1.2830.98
64_P67_G1.2230.97
90_P93_K1.2170.97
17_T21_F1.2100.96
129_G133_V1.1850.96
137_D140_A1.1830.96
102_A116_G1.1620.96
35_G38_D1.1440.95
47_I83_G1.1300.95
110_P113_P1.1170.94
110_P116_G1.0890.94
136_P141_W1.0600.93
20_D114_R1.0600.93
4_D46_Y1.0480.92
47_I70_A1.0350.92
9_D12_R1.0310.92
138_L141_W1.0220.91
67_G126_V1.0160.91
22_Q26_S1.0130.91
100_A103_K1.0060.91
71_V127_F0.9830.90
135_P140_A0.9750.89
66_G73_Y0.9660.89
138_L142_N0.9630.89
63_I68_D0.9630.89
57_D60_A0.9600.89
102_A108_I0.9570.88
47_I126_V0.9490.88
54_S57_D0.9490.88
68_D130_S0.9050.85
9_D23_P0.9020.85
32_Q35_G0.8890.84
80_A97_A0.8870.84
108_I116_G0.8850.84
135_P138_L0.8740.83
120_S123_T0.8690.83
47_I80_A0.8680.83
64_P130_S0.8680.83
48_V96_E0.8650.83
137_D141_W0.8640.83
34_W38_D0.8540.82
18_D25_T0.8520.82
65_G68_D0.8490.82
8_S12_R0.8340.80
107_G111_P0.8180.79
4_D28_R0.8180.79
22_Q27_F0.8140.79
64_P68_D0.8130.79
67_G130_S0.8120.79
44_D83_G0.8110.78
38_D41_A0.8110.78
108_I111_P0.8100.78
136_P140_A0.8030.78
46_Y120_S0.8030.78
112_D116_G0.8020.78
70_A77_V0.7950.77
67_G73_Y0.7920.77
59_R63_I0.7880.76
74_N122_V0.7870.76
139_A143_A0.7790.76
9_D40_D0.7790.76
78_Y97_A0.7760.75
62_G67_G0.7700.75
72_V78_Y0.7610.74
9_D17_T0.7600.74
111_P116_G0.7540.73
140_A143_A0.7500.73
135_P141_W0.7470.73
63_I67_G0.7420.72
112_D117_G0.7390.72
67_G128_P0.7380.72
66_G69_Y0.7330.71
16_G54_S0.7310.71
111_P118_S0.7250.70
102_A110_P0.7220.70
2_D93_K0.7150.69
112_D118_S0.7070.68
27_F34_W0.7020.68
129_G136_P0.7000.68
39_L44_D0.6990.68
8_S128_P0.6960.67
12_R40_D0.6950.67
47_I82_V0.6950.67
102_A124_Y0.6900.67
66_G72_V0.6900.67
128_P133_V0.6850.66
27_F32_Q0.6810.65
4_D24_Q0.6810.65
137_D142_N0.6780.65
47_I72_V0.6760.65
24_Q38_D0.6760.65
89_G93_K0.6720.64
56_F61_H0.6720.64
139_A142_N0.6670.64
73_Y121_G0.6600.63
94_I107_G0.6570.63
23_P27_F0.6500.62
136_P142_N0.6480.62
40_D44_D0.6430.61
14_G103_K0.6430.61
18_D22_Q0.6410.61
132_A136_P0.6410.61
51_G55_I0.6400.61
16_G20_D0.6350.60
8_S11_D0.6350.60
60_A130_S0.6290.59
47_I71_V0.6250.59
10_G49_L0.6210.58
71_V90_P0.6170.58
67_G72_V0.6160.58
73_Y77_V0.6090.57
51_G119_D0.6080.57
14_G40_D0.6080.57
4_D7_G0.6050.56
51_G91_S0.6050.56
20_D113_P0.6040.56
99_Y111_P0.5990.56
67_G70_A0.5970.55
26_S51_G0.5840.54
9_D21_F0.5820.54
49_L129_G0.5760.53
56_F94_I0.5720.52
21_F28_R0.5720.52
25_T33_S0.5700.52
4_D20_D0.5680.52
3_I17_T0.5680.52
68_D73_Y0.5660.52
117_G120_S0.5600.51
102_A113_P0.5590.51
52_P57_D0.5580.51
41_A112_D0.5570.50
27_F134_P0.5550.50
13_G54_S0.5540.50
14_G129_G0.5530.50
4_D84_D0.5510.50
71_V77_V0.5480.49
104_A142_N0.5480.49
53_S114_R0.5440.49
128_P131_A0.5430.49
2_D21_F0.5370.48
108_I112_D0.5370.48
5_C20_D0.5360.48
38_D141_W0.5310.47
3_I42_E0.5300.47
48_V95_G0.5300.47
4_D15_C0.5300.47
1_M97_A0.5260.47
36_I39_L0.5260.47
70_A122_V0.5250.46
58_Y134_P0.5250.46
37_R81_I0.5250.46
69_Y119_D0.5230.46
64_P82_V0.5220.46
102_A118_S0.5170.45
76_K133_V0.5140.45
47_I102_A0.5100.45
58_Y61_H0.5100.45
5_C113_P0.5090.44
48_V97_A0.5040.44
117_G122_V0.5030.44
6_D96_E0.5030.44
23_P26_S0.5020.44
67_G82_V0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l58A 1 0.1595 11.3 0.943 Contact Map
2yqkA 1 0.2086 9 0.946 Contact Map
2cqqA 1 0.2025 6.4 0.95 Contact Map
1wudA 3 0.3742 6.1 0.95 Contact Map
3kdqA 5 0.3804 5.9 0.95 Contact Map
3c4zA 2 0.2577 5.7 0.951 Contact Map
2pokA 2 0.2025 5.1 0.952 Contact Map
3tp4A 2 0.2638 4.3 0.953 Contact Map
2kbwB 1 0.1534 4.3 0.953 Contact Map
2rhfA 1 0.3742 4 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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