GREMLIN Database
TctB - Tripartite tricarboxylate transporter TctB family
PFAM: PF07331 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 135 (132)
Sequences: 47168 (37106)
Seq/√Len: 3229.7
META: 0.893

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_Y93_T3.4901.00
18_G21_R3.3681.00
107_R110_R3.0171.00
124_L128_K2.9861.00
17_W20_L2.9651.00
8_L40_A2.3081.00
128_K131_G2.2931.00
37_V41_L2.2761.00
111_A115_A2.1231.00
94_A119_T2.0761.00
29_G33_F2.0701.00
109_L113_L2.0511.00
115_A119_T2.0021.00
123_Y127_V1.9471.00
98_F115_A1.8061.00
91_L94_A1.7911.00
63_W67_L1.7731.00
73_V100_L1.6991.00
64_R68_R1.6511.00
83_L92_A1.6321.00
83_L86_P1.5981.00
110_R113_L1.5931.00
110_R114_V1.5611.00
98_F111_A1.5401.00
123_Y128_K1.5271.00
63_W66_L1.5161.00
4_G47_L1.5051.00
105_R111_A1.4801.00
125_L129_L1.4791.00
113_L117_V1.4651.00
33_F37_V1.4431.00
15_F36_G1.4351.00
16_A33_F1.4291.00
31_F35_L1.4231.00
97_L101_L1.4151.00
96_F100_L1.3241.00
76_A99_A1.3191.00
62_V66_L1.2951.00
65_G69_R1.2871.00
8_L43_G1.2831.00
26_P30_F1.2801.00
30_F34_L1.2721.00
16_A36_G1.2631.00
106_R110_R1.2591.00
17_W21_R1.2571.00
79_A83_L1.2111.00
94_A116_V1.2111.00
108_W111_A1.2091.00
117_V121_V1.2081.00
7_L43_G1.2061.00
12_G40_A1.1641.00
44_L48_V1.1601.00
107_R111_A1.1441.00
26_P29_G1.1301.00
20_L33_F1.1211.00
89_F93_T1.1211.00
34_L37_V1.1191.00
14_A18_G1.1131.00
33_F36_G1.1051.00
65_G68_R1.0661.00
82_L86_P1.0571.00
41_L45_L1.0571.00
68_R72_A1.0531.00
124_L129_L1.0511.00
101_L111_A1.0461.00
69_R72_A1.0421.00
90_L119_T1.0311.00
38_L42_L1.0291.00
87_L92_A1.0241.00
101_L114_V1.0211.00
116_V119_T1.0151.00
105_R110_R1.0141.00
67_L71_L1.0121.00
94_A98_F1.0111.00
90_L123_Y1.0001.00
121_V125_L0.9921.00
83_L87_L0.9901.00
55_G58_P0.9731.00
80_Y92_A0.9571.00
49_R52_R0.9571.00
4_G43_G0.9451.00
43_G47_L0.9261.00
3_A7_L0.9161.00
60_P63_W0.9101.00
52_R55_G0.9031.00
93_T119_T0.9001.00
19_A33_F0.9001.00
94_A115_A0.8841.00
109_L112_L0.8611.00
13_L17_W0.8611.00
129_L133_P0.8541.00
89_F122_I0.8521.00
117_V120_V0.8521.00
58_P61_F0.8511.00
62_V67_L0.8501.00
36_G40_A0.8451.00
24_A27_G0.8431.00
66_L69_R0.8391.00
34_L38_L0.8381.00
62_V65_G0.8221.00
15_F19_A0.8161.00
96_F99_A0.8131.00
16_A19_A0.8061.00
40_A44_L0.8011.00
51_A54_G0.8011.00
121_V124_L0.8001.00
97_L100_L0.7971.00
90_L127_V0.7931.00
55_G60_P0.7901.00
43_G46_L0.7831.00
61_F65_G0.7671.00
3_A6_L0.7641.00
51_A55_G0.7551.00
97_L118_L0.7481.00
61_F66_L0.7471.00
125_L130_L0.7451.00
42_L46_L0.7451.00
15_F20_L0.7421.00
106_R111_A0.7401.00
82_L85_E0.7381.00
102_G105_R0.7371.00
120_V124_L0.7341.00
16_A20_L0.7331.00
59_E62_V0.7291.00
8_L47_L0.7261.00
114_V117_V0.7161.00
98_F108_W0.7151.00
80_Y84_L0.7151.00
87_L91_L0.7141.00
64_R67_L0.7121.00
76_A96_F0.7051.00
112_L115_A0.6961.00
106_R109_L0.6951.00
98_F101_L0.6881.00
45_L48_V0.6871.00
68_R71_L0.6761.00
108_W112_L0.6711.00
98_F112_L0.6641.00
54_G60_P0.6571.00
31_F36_G0.6491.00
127_V131_G0.6491.00
102_G106_R0.6411.00
25_G30_F0.6401.00
105_R108_W0.6301.00
24_A30_F0.6291.00
16_A40_A0.6291.00
71_L75_A0.6281.00
15_F18_G0.6251.00
114_V118_L0.6251.00
5_L9_A0.6221.00
37_V40_A0.6181.00
96_F101_L0.6101.00
86_P92_A0.6001.00
112_L116_V0.5971.00
60_P65_G0.5961.00
39_L43_G0.5961.00
54_G57_P0.5951.00
72_A75_A0.5921.00
84_L89_F0.5911.00
71_L74_L0.5861.00
119_T123_Y0.5831.00
4_G7_L0.5811.00
50_A53_A0.5761.00
78_V81_A0.5751.00
57_P60_P0.5751.00
61_F64_R0.5751.00
77_L96_F0.5691.00
79_A82_L0.5681.00
127_V133_P0.5681.00
95_L99_A0.5641.00
84_L92_A0.5581.00
60_P64_R0.5571.00
81_A84_L0.5561.00
76_A100_L0.5521.00
49_R53_A0.5501.00
88_G92_A0.5471.00
76_A130_L0.5461.00
70_V74_L0.5421.00
53_A57_P0.5381.00
31_F130_L0.5361.00
69_R73_V0.5351.00
70_V73_V0.5291.00
64_R69_R0.5281.00
16_A37_V0.5271.00
75_A79_A0.5271.00
97_L115_A0.5241.00
36_G39_L0.5231.00
51_A56_E0.5231.00
50_A54_G0.5221.00
25_G29_G0.5211.00
95_L98_F0.5181.00
90_L94_A0.5151.00
118_L122_I0.5121.00
78_V82_L0.5091.00
35_L39_L0.5071.00
53_A56_E0.5051.00
51_A57_P0.5011.00
76_A79_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4djkA 2 0.8667 4.6 0.899 Contact Map
2a65A 2 0.4444 4.4 0.899 Contact Map
2xq2A 2 0.3481 3.8 0.903 Contact Map
3giaA 1 0.4148 3.7 0.903 Contact Map
4o6yA 2 0.3778 3 0.908 Contact Map
3l1lA 2 0.8519 2.8 0.909 Contact Map
3bo0B 1 0.4815 2.1 0.915 Contact Map
3dinD 1 0.4148 2.1 0.915 Contact Map
3j01B 1 0.7185 2 0.916 Contact Map
4qi1A 3 0.9926 1.9 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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