GREMLIN Database
DUF1467 - Protein of unknown function (DUF1467)
PFAM: PF07330 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (81)
Sequences: 8255 (4692)
Seq/√Len: 521.4
META: 0.933

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_V40_T2.6661.00
49_R52_R2.6191.00
70_A74_S2.4091.00
10_Y62_A2.2971.00
6_A65_F2.2821.00
51_G55_L2.2291.00
29_Q40_T2.0061.00
69_Y73_V1.9431.00
14_W58_T1.8281.00
68_I72_I1.7891.00
24_F56_W1.6501.00
5_S8_A1.6341.00
28_T43_G1.5701.00
65_F69_Y1.5671.00
27_R32_A1.5581.00
78_T81_D1.5501.00
21_V24_F1.5381.00
29_Q35_V1.5261.00
15_W18_L1.5201.00
55_L59_V1.4761.00
32_A46_A1.4721.00
13_I68_I1.3921.00
17_V57_T1.3881.00
50_L53_K1.3641.00
29_Q34_E1.3451.00
11_F15_W1.3031.00
59_V63_V1.2871.00
2_S5_S1.2821.00
13_I65_F1.2661.00
13_I64_L1.2561.00
50_L54_L1.2351.00
52_R56_W1.2161.00
21_V57_T1.2041.00
17_V60_V1.1831.00
3_W7_I1.1821.00
8_A11_F1.1701.00
17_V64_L1.1611.00
48_P53_K1.1611.00
58_T62_A1.1501.00
51_G54_L1.1421.00
66_A70_A1.1321.00
67_L71_V1.1211.00
71_V76_W1.1011.00
10_Y58_T1.0791.00
8_A12_L1.0641.00
16_L20_A1.0441.00
56_W59_V1.0211.00
20_A60_V1.0151.00
2_S6_A0.9681.00
21_V56_W0.9601.00
28_T31_E0.9481.00
63_V67_L0.9221.00
4_T7_I0.9191.00
75_G78_T0.9031.00
27_R46_A0.8951.00
29_Q37_V0.8741.00
18_L57_T0.8661.00
62_A65_F0.8521.00
35_V40_T0.8451.00
20_A24_F0.8441.00
49_R53_K0.8411.00
17_V20_A0.8341.00
35_V38_P0.8281.00
3_W6_A0.8181.00
34_E37_V0.8061.00
17_V61_A0.8041.00
28_T41_D0.8001.00
70_A75_G0.7891.00
18_L54_L0.7781.00
30_E35_V0.7711.00
52_R55_L0.7641.00
49_R56_W0.7521.00
13_I17_V0.7511.00
29_Q46_A0.7501.00
13_I16_L0.7471.00
71_V77_I0.7361.00
13_I61_A0.7201.00
70_A73_V0.7051.00
79_L82_L0.7031.00
47_N51_G0.7021.00
5_S9_I0.6901.00
30_E46_A0.6901.00
75_G80_D0.6791.00
30_E42_P0.6731.00
71_V74_S0.6671.00
67_L70_A0.6601.00
4_T8_A0.6561.00
6_A69_Y0.6511.00
60_V63_V0.6331.00
74_S78_T0.6331.00
9_I68_I0.6201.00
26_V43_G0.6161.00
56_W60_V0.6101.00
23_P53_K0.6071.00
6_A9_I0.6001.00
70_A76_W0.5920.99
22_L26_V0.5920.99
12_L16_L0.5830.99
53_K57_T0.5820.99
28_T33_G0.5760.99
48_P51_G0.5720.99
18_L53_K0.5690.99
10_Y61_A0.5670.99
19_F22_L0.5650.99
53_K56_W0.5580.99
72_I75_G0.5540.99
29_Q44_A0.5470.99
21_V60_V0.5450.99
20_A23_P0.5420.99
58_T61_A0.5410.99
59_V62_A0.5350.99
71_V75_G0.5330.99
49_R55_L0.5300.99
41_D44_A0.5290.99
77_I81_D0.5250.99
22_L53_K0.5210.99
74_S77_I0.5200.99
17_V56_W0.5150.99
18_L50_L0.5140.98
67_L76_W0.5110.98
54_L57_T0.5070.98
61_A65_F0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mk7C 2 1 12.2 0.892 Contact Map
2ww9A 1 0.9398 10.1 0.896 Contact Map
2yevB 1 0.8795 6.8 0.904 Contact Map
4httA 1 0.988 6.2 0.905 Contact Map
4w251 1 0.988 6.2 0.905 Contact Map
3j01A 1 0.9759 5.5 0.908 Contact Map
2zjsY 2 1 4.7 0.911 Contact Map
3b55A 1 0.1205 4.6 0.911 Contact Map
3s8fA 1 0.9759 4.6 0.911 Contact Map
2a3mA 1 0.1446 4 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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