GREMLIN Database
DUF1461 - Protein of unknown function (DUF1461)
PFAM: PF07314 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 189 (182)
Sequences: 4389 (3738)
Seq/√Len: 277.1
META: 0.85

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_D44_K3.4621.00
43_S46_E3.3911.00
14_L100_L2.9391.00
84_S170_L2.7641.00
160_L163_E2.7401.00
159_T163_E2.5931.00
31_Y51_A2.5281.00
78_N178_D2.4911.00
30_E33_K2.4781.00
22_P25_P2.3891.00
10_L104_L2.3681.00
35_G38_E2.3671.00
174_D177_T2.3561.00
60_N90_K2.2251.00
79_E84_S2.1761.00
169_D172_L2.1181.00
29_F33_K2.0941.00
179_T182_R2.0651.00
81_R170_L2.0571.00
28_E48_L2.0571.00
159_T171_W1.9951.00
78_N81_R1.9691.00
113_L117_R1.9281.00
167_S170_L1.8211.00
44_K48_L1.7711.00
125_R128_R1.7221.00
170_L173_F1.7011.00
81_R173_F1.6661.00
20_L93_F1.6541.00
156_Q160_L1.6541.00
46_E49_R1.6531.00
34_Y187_G1.6441.00
78_N82_E1.6151.00
76_L179_T1.6121.00
169_D173_F1.6051.00
26_F30_E1.5861.00
161_F165_F1.5661.00
180_L183_L1.5451.00
72_V75_E1.5321.00
13_L96_A1.5201.00
112_L116_R1.4911.00
91_N95_L1.4671.00
98_R102_I1.4521.00
21_N59_N1.4331.00
92_L95_L1.4041.00
67_D70_V1.3931.00
145_V149_L1.3891.00
84_S88_D1.3881.00
30_E34_Y1.3771.00
178_D181_I1.3751.00
173_F180_L1.3721.00
94_Q98_R1.3631.00
87_A91_N1.3581.00
168_N173_F1.3491.00
10_L107_L1.3331.00
10_L103_S1.3231.00
106_L110_L1.3141.00
150_A157_F1.3121.00
39_T182_R1.2871.00
66_L86_M1.2841.00
153_D156_Q1.2761.00
134_A138_L1.2681.00
137_L141_A1.2541.00
48_L52_D1.2101.00
155_D186_E1.2071.00
149_L157_F1.2041.00
134_A137_L1.1931.00
51_A184_F1.1891.00
124_W128_R1.1891.00
174_D178_D1.1881.00
160_L164_L1.1771.00
71_T74_G1.1731.00
110_L114_L1.1621.00
36_V39_T1.1391.00
86_M180_L1.1291.00
124_W127_L1.1261.00
60_N63_R1.1231.00
54_L86_M1.1151.00
66_L70_V1.1031.00
132_L136_G1.0991.00
42_F47_L1.0981.00
49_R53_E1.0961.00
25_P29_F1.0911.00
27_Y55_L1.0831.00
54_L184_F1.0741.00
17_R21_N1.0541.00
163_E168_N1.0481.00
17_R100_L1.0371.00
54_L58_L1.0371.00
84_S87_A1.0331.00
111_L115_L1.0221.00
57_Y90_K1.0201.00
28_E52_D1.0181.00
101_L105_V1.0021.00
25_P28_E1.0011.00
37_P40_T0.9951.00
4_A8_P0.9941.00
81_R178_D0.9931.00
18_L22_P0.9891.00
184_F189_F0.9771.00
16_V96_A0.9741.00
98_R101_L0.9731.00
92_L96_A0.9671.00
21_N97_L0.9641.00
10_L100_L0.9591.00
168_N171_W0.9591.00
94_Q97_L0.9581.00
13_L17_R0.9571.00
50_V76_L0.9541.00
123_L127_L0.9511.00
21_N25_P0.9391.00
59_N97_L0.9291.00
88_D167_S0.9281.00
9_L13_L0.9221.00
123_L126_L0.9091.00
163_E167_S0.9001.00
51_A55_L0.8991.00
66_L72_V0.8871.00
3_F107_L0.8801.00
50_V54_L0.8761.00
37_P47_L0.8751.00
65_D68_V0.8731.00
81_R84_S0.8691.00
149_L156_Q0.8651.00
95_L99_V0.8591.00
114_L119_K0.8571.00
180_L184_F0.8561.00
133_L137_L0.8501.00
57_Y87_A0.8501.00
50_V70_V0.8471.00
115_L118_R0.8421.00
116_R120_K0.8351.00
49_R70_V0.8150.99
37_P44_K0.8120.99
136_G139_T0.8110.99
28_E32_D0.8090.99
6_L110_L0.8070.99
155_D159_T0.8070.99
31_Y36_V0.8060.99
78_N83_L0.8060.99
54_L77_F0.7990.99
69_P72_V0.7920.99
30_E36_V0.7830.99
53_E68_V0.7770.99
131_G135_G0.7750.99
77_F82_E0.7690.99
42_F76_L0.7690.99
19_L22_P0.7680.99
86_M89_V0.7630.99
149_L153_D0.7600.99
157_F160_L0.7600.99
70_V76_L0.7540.99
103_S107_L0.7530.99
81_R169_D0.7420.99
10_L13_L0.7370.99
29_F32_D0.7300.99
6_L103_S0.7270.99
135_G139_T0.7240.99
157_F165_F0.7210.99
165_F173_F0.7210.99
6_L106_L0.7170.99
76_L183_L0.7150.99
31_Y34_Y0.7130.99
8_P11_L0.7120.99
185_P189_F0.7080.98
159_T186_E0.7070.98
3_F8_P0.7060.98
181_I184_F0.7050.98
15_S19_L0.7040.98
53_E63_R0.7000.98
57_Y60_N0.7000.98
112_L115_L0.6990.98
60_N64_E0.6990.98
117_R120_K0.6940.98
71_T75_E0.6920.98
47_L183_L0.6920.98
31_Y47_L0.6900.98
56_D60_N0.6900.98
154_F186_E0.6800.98
78_N177_T0.6770.98
17_R97_L0.6750.98
153_D160_L0.6740.98
156_Q159_T0.6720.98
130_R134_A0.6650.98
53_E56_D0.6610.98
93_F184_F0.6610.98
18_L21_N0.6600.98
100_L103_S0.6530.97
67_D71_T0.6520.97
47_L50_V0.6460.97
153_D157_F0.6450.97
43_S49_R0.6440.97
85_H89_V0.6380.97
152_I160_L0.6370.97
4_A138_L0.6350.97
122_R125_R0.6340.97
116_R119_K0.6310.97
12_L22_P0.6300.97
85_H162_H0.6290.97
70_V73_D0.6260.97
13_L100_L0.6250.97
51_A188_F0.6230.97
122_R126_L0.6220.97
172_L178_D0.6210.97
143_L146_L0.6180.96
31_Y48_L0.6140.96
149_L160_L0.6110.96
140_L144_V0.6100.96
133_L136_G0.6080.96
158_F173_F0.6080.96
51_A86_M0.6050.96
95_L98_R0.6010.96
165_F168_N0.5930.95
161_F164_L0.5860.95
120_K123_L0.5850.95
165_F170_L0.5820.95
49_R52_D0.5810.95
166_F171_W0.5790.95
93_F158_F0.5770.95
97_L101_L0.5770.95
51_A54_L0.5770.95
68_V71_T0.5760.95
167_S173_F0.5730.95
67_D72_V0.5730.95
158_F162_H0.5710.94
132_L139_T0.5700.94
16_V19_L0.5670.94
63_R67_D0.5660.94
22_P29_F0.5630.94
168_N172_L0.5610.94
47_L51_A0.5600.94
31_Y37_P0.5580.94
184_F188_F0.5510.93
97_L100_L0.5500.93
40_T47_L0.5500.93
13_L20_L0.5490.93
176_S179_T0.5480.93
17_R96_A0.5480.93
130_R141_A0.5470.93
60_N65_D0.5460.93
42_F46_E0.5460.93
58_L184_F0.5450.93
82_E179_T0.5450.93
4_A134_A0.5430.93
13_L16_V0.5400.93
173_F184_F0.5390.93
67_D83_L0.5380.93
6_L107_L0.5360.92
142_L146_L0.5320.92
8_P17_R0.5320.92
45_E48_L0.5310.92
42_F179_T0.5300.92
84_S168_N0.5260.92
13_L22_P0.5240.92
115_L120_K0.5220.91
139_T143_L0.5210.91
36_V187_G0.5180.91
58_L90_K0.5170.91
66_L83_L0.5150.91
147_G151_L0.5110.91
88_D92_L0.5100.90
40_T182_R0.5090.90
178_D182_R0.5090.90
5_L111_L0.5080.90
46_E72_V0.5080.90
65_D69_P0.5070.90
167_S171_W0.5050.90
61_G64_E0.5050.90
132_L135_G0.5040.90
56_D61_G0.5030.90
136_G140_L0.5010.90
82_E183_L0.5000.90
21_N55_L0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gsmB 1 0.5979 5.8 0.941 Contact Map
4pd6A 3 0.4233 3 0.949 Contact Map
2kncA 1 0.2116 2.1 0.953 Contact Map
3dctB 1 0.0582 1.8 0.954 Contact Map
2lk9A 1 0.127 1.8 0.955 Contact Map
2mofA 1 0.2222 1.6 0.956 Contact Map
4g6vB 1 0.2434 1.6 0.956 Contact Map
2ks1B 1 0.2328 1.6 0.956 Contact Map
2i53A 1 0.3228 1.5 0.956 Contact Map
4hkrA 3 0.2857 1.4 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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