GREMLIN Database
DUF1456 - Protein of unknown function (DUF1456)
PFAM: PF07308 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (68)
Sequences: 8634 (4793)
Seq/√Len: 581.2
META: 0.875

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_G54_V2.2551.00
31_S34_E2.0581.00
28_F57_N2.0101.00
21_E65_K1.9951.00
16_D32_K1.8411.00
25_L64_I1.7871.00
24_A29_E1.7381.00
30_V38_F1.7231.00
38_F54_V1.7211.00
26_A57_N1.6961.00
18_D65_K1.6961.00
25_L65_K1.6531.00
15_K18_D1.5921.00
28_F54_V1.5531.00
22_I65_K1.5441.00
20_I35_L1.5001.00
26_A64_I1.4781.00
9_R16_D1.4661.00
37_A48_R1.4071.00
12_L62_L1.4061.00
14_L22_I1.3171.00
4_I55_L1.3131.00
16_D36_S1.2901.00
22_I61_G1.2751.00
60_N64_I1.2721.00
32_K36_S1.2601.00
53_Q57_N1.2491.00
60_N63_I1.2421.00
20_I32_K1.2421.00
18_D21_E1.2351.00
37_A46_N1.1741.00
7_K11_A1.1611.00
50_C54_V1.1561.00
23_F54_V1.1471.00
5_L19_M1.1401.00
17_E32_K1.1301.00
19_M35_L1.0991.00
8_L11_A1.0861.00
6_R10_Y1.0661.00
37_A40_R1.0511.00
6_R16_D1.0431.00
26_A61_G1.0251.00
40_R46_N1.0221.00
33_H36_S1.0031.00
21_E24_A0.9911.00
30_V35_L0.9851.00
19_M58_F0.9721.00
8_L59_L0.9671.00
38_F50_C0.9661.00
14_L62_L0.9131.00
21_E25_L0.8911.00
62_L66_K0.8851.00
23_F28_F0.8841.00
22_I58_F0.8651.00
30_V54_V0.8351.00
22_I62_L0.8231.00
33_H37_A0.8191.00
36_S40_R0.8121.00
17_E21_E0.8061.00
54_V57_N0.7801.00
1_N52_D0.7741.00
34_E48_R0.7501.00
28_F53_Q0.7431.00
3_D7_K0.7331.00
63_I68_G0.7291.00
42_E47_Y0.7161.00
56_R60_N0.7031.00
35_L39_L0.7031.00
19_M23_F0.6951.00
39_L50_C0.6901.00
59_L63_I0.6901.00
14_L19_M0.6861.00
31_S36_S0.6861.00
7_K10_Y0.6861.00
41_K44_H0.6601.00
9_R13_D0.6411.00
63_I66_K0.6231.00
5_L38_F0.6221.00
23_F35_L0.6101.00
5_L50_C0.6091.00
23_F30_V0.6081.00
14_L18_D0.6031.00
26_A60_N0.6011.00
3_D6_R0.6011.00
40_R44_H0.5761.00
3_D9_R0.5701.00
11_A14_L0.5540.99
6_R9_R0.5520.99
20_I29_E0.5440.99
19_M39_L0.5390.99
20_I24_A0.5380.99
2_N47_Y0.5360.99
23_F58_F0.5330.99
3_D63_I0.5270.99
20_I30_V0.5220.99
47_Y50_C0.5120.99
20_I36_S0.5090.99
34_E37_A0.5070.99
52_D56_R0.5060.99
10_Y41_K0.5060.99
27_G64_I0.5010.99
34_E38_F0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bl0C 1 0.8824 28.5 0.857 Contact Map
2dsjA 2 0.9559 28.1 0.857 Contact Map
4hkmA 2 0.9559 27.8 0.857 Contact Map
1tizA 1 0.8529 26.4 0.859 Contact Map
2m1uA 1 0.9412 25.6 0.859 Contact Map
2pmyA 4 0.8971 25.6 0.859 Contact Map
2kn2A 1 1 25.1 0.86 Contact Map
1yx7A 1 0.9853 24.8 0.861 Contact Map
2becA 1 1 24.5 0.861 Contact Map
1brwA 2 0.9559 23.9 0.862 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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