GREMLIN Database
DUF1453 - Protein of unknown function (DUF1453)
PFAM: PF07301 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 145 (142)
Sequences: 1880 (1393)
Seq/√Len: 116.9
META: 0.716

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_L129_G4.1441.00
94_L98_G3.6411.00
53_P56_W2.6331.00
33_L37_F2.5371.00
82_G85_Y2.4721.00
119_L122_L2.2801.00
13_L17_L2.2701.00
110_L113_S2.2421.00
70_P73_R2.1881.00
26_V29_K2.1311.00
100_L104_L2.1111.00
54_W57_A1.9711.00
93_L97_L1.9481.00
65_A133_P1.9111.00
8_I12_A1.8901.00
137_E141_R1.8581.00
140_L143_R1.7961.00
88_R92_F1.7561.00
81_D85_Y1.7491.00
33_L36_L1.7371.00
30_L34_P1.7221.00
32_I139_Y1.7161.00
33_L135_R1.6681.00
105_G108_G1.5991.00
41_G45_F1.5861.00
136_L140_L1.5451.00
10_I14_V1.4791.00
25_P28_L1.4771.00
25_P29_K1.4551.00
103_R107_R1.4431.00
68_G72_G1.4381.00
5_L15_L1.4011.00
24_R30_L1.3941.00
140_L144_R1.3931.00
139_Y143_R1.3911.00
106_L110_L1.3881.00
104_L107_R1.3821.00
31_W138_M1.3761.00
11_A15_L1.3661.00
76_R141_R1.3631.00
54_W58_L1.3551.00
20_R23_R1.3521.00
43_L47_V1.3461.00
12_A16_A1.3431.00
30_L35_P1.3131.00
9_V13_L1.3091.00
22_M27_P1.3081.00
101_A104_L1.2951.00
37_F40_T1.2680.99
98_G105_G1.2080.99
17_L21_R1.1980.99
122_L125_L1.1820.99
89_S92_F1.1690.99
52_V125_L1.1500.99
7_A10_I1.1320.99
136_L141_R1.1290.99
56_W60_A1.1220.99
79_V82_G1.1160.99
74_T95_I1.1120.99
7_A11_A1.1110.99
66_A70_P1.1050.98
61_L125_L1.0940.98
80_D85_Y1.0800.98
115_S118_Q1.0690.98
19_M22_M1.0670.98
31_W34_P1.0580.98
13_L16_A1.0580.98
4_T7_A1.0580.98
12_A32_I1.0580.98
47_V50_F1.0560.98
39_A42_A1.0540.98
78_E87_K1.0360.98
18_R21_R1.0300.98
123_F127_A1.0170.97
6_I13_L1.0160.97
77_I138_M1.0110.97
22_M25_P1.0090.97
45_F48_P1.0030.97
81_D84_I1.0020.97
79_V84_I0.9900.97
23_R28_L0.9830.97
57_A125_L0.9810.97
101_A105_G0.9690.97
22_M28_L0.9670.97
84_I88_R0.9590.96
91_A95_I0.9470.96
57_A122_L0.9460.96
43_L46_L0.9410.96
67_L134_W0.9350.96
24_R29_K0.9350.96
128_F135_R0.9200.95
4_T8_I0.9170.95
15_L20_R0.8920.95
118_Q122_L0.8900.94
45_F51_R0.8860.94
132_V136_L0.8800.94
65_A69_W0.8760.94
15_L19_M0.8720.94
118_Q121_D0.8720.94
13_L20_R0.8560.93
133_P137_E0.8450.93
134_W138_M0.8290.92
90_K94_L0.8290.92
18_R22_M0.8270.92
14_V17_L0.8270.92
110_L114_L0.8250.92
91_A103_R0.8250.92
90_K95_I0.8230.92
105_G112_Q0.8200.92
37_F128_F0.8110.91
26_V31_W0.8030.91
59_A122_L0.7970.90
61_L132_V0.7950.90
115_S120_T0.7940.90
39_A128_F0.7900.90
24_R27_P0.7880.90
130_M134_W0.7850.90
24_R28_L0.7830.90
91_A94_L0.7820.90
75_S138_M0.7770.89
10_I13_L0.7740.89
140_L145_L0.7710.89
44_M48_P0.7700.89
90_K93_L0.7690.89
32_I36_L0.7680.89
12_A15_L0.7660.89
28_L139_Y0.7640.89
72_G77_I0.7570.88
133_P138_M0.7510.88
75_S86_L0.7500.88
114_L122_L0.7490.88
137_E142_Y0.7470.87
93_L96_L0.7440.87
23_R27_P0.7410.87
79_V83_H0.7360.87
48_P51_R0.7350.87
105_G109_Y0.7290.86
9_V12_A0.7240.86
104_L116_V0.7210.86
87_K91_A0.7210.86
133_P136_L0.7180.85
10_I21_R0.7160.85
22_M96_L0.7140.85
82_G88_R0.7000.84
31_W35_P0.7000.84
102_V106_L0.7000.84
14_V20_R0.6900.83
45_F125_L0.6870.83
12_A116_V0.6850.82
52_V124_F0.6810.82
75_S131_I0.6800.82
130_M138_M0.6790.82
96_L99_L0.6770.82
36_L141_R0.6690.81
67_L70_P0.6670.81
6_I10_I0.6660.81
69_W73_R0.6630.80
44_M99_L0.6610.80
69_W72_G0.6510.79
16_A20_R0.6400.78
8_I13_L0.6400.78
137_E144_R0.6380.78
86_L89_S0.6280.77
117_G121_D0.6230.76
103_R127_A0.6200.76
21_R24_R0.6190.76
22_M29_K0.6120.75
20_R27_P0.6110.75
35_P39_A0.6040.74
11_A70_P0.6000.73
66_A133_P0.5990.73
111_G115_S0.5910.72
121_D124_F0.5910.72
76_R87_K0.5900.72
124_F132_V0.5850.72
42_A125_L0.5840.71
139_Y142_Y0.5830.71
53_P118_Q0.5800.71
35_P38_M0.5760.70
36_L42_A0.5760.70
21_R26_V0.5660.69
38_M128_F0.5650.69
75_S92_F0.5640.69
73_R87_K0.5590.68
28_L32_I0.5560.68
26_V30_L0.5550.68
44_M47_V0.5480.67
46_L49_P0.5480.67
38_M41_G0.5460.66
35_P41_G0.5430.66
121_D125_L0.5400.65
5_L9_V0.5380.65
108_G113_S0.5340.65
92_F96_L0.5340.65
7_A104_L0.5330.64
129_G135_R0.5330.64
57_A110_L0.5240.63
116_V120_T0.5240.63
19_M28_L0.5230.63
40_T50_F0.5230.63
80_D83_H0.5220.63
11_A100_L0.5200.63
70_P92_F0.5190.62
68_G80_D0.5180.62
56_W118_Q0.5160.62
60_A125_L0.5150.62
70_P109_Y0.5130.62
17_L27_P0.5080.61
86_L92_F0.5070.61
84_I89_S0.5060.61
15_L21_R0.5050.60
90_K101_A0.5020.60
131_I137_E0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o9uB 2 0.9517 23.8 0.895 Contact Map
4o93B 1 0.9448 12.6 0.908 Contact Map
2ks1B 1 0.1724 9.7 0.912 Contact Map
2jwaA 2 0.1862 9.4 0.912 Contact Map
3l1lA 2 0.5586 8.1 0.915 Contact Map
2l2tA 2 0.1793 7.3 0.917 Contact Map
4dx5A 3 0.9793 5.4 0.922 Contact Map
5a2fA 1 0 4.2 0.926 Contact Map
1pw4A 1 0.9586 3.7 0.928 Contact Map
2xq2A 2 0.931 3.2 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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