GREMLIN Database
MauE - Methylamine utilisation protein MauE
PFAM: PF07291 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 184 (157)
Sequences: 3121 (2777)
Seq/√Len: 221.6
META: 0.88

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_A65_A3.7641.00
21_F85_L3.3781.00
31_D34_G3.2871.00
64_V81_A3.2131.00
67_A77_A3.0811.00
64_V80_A2.9391.00
25_A62_L2.9121.00
64_V77_A2.8641.00
118_W121_V2.8341.00
95_N100_R2.6551.00
14_R74_R2.5901.00
25_A58_P2.3891.00
35_F39_L2.1401.00
27_H88_F2.0861.00
39_L53_V2.0371.00
17_L131_A2.0341.00
39_L50_A2.0211.00
13_A130_L2.0191.00
89_A128_A2.0061.00
45_L53_V1.9261.00
18_A65_A1.9101.00
93_A121_V1.8691.00
94_I98_R1.8611.00
82_A128_A1.8011.00
25_A65_A1.7251.00
70_L73_T1.7091.00
92_I116_I1.6901.00
142_R148_D1.6821.00
42_Y106_G1.6401.00
37_A41_A1.6121.00
74_R77_A1.6031.00
117_S120_L1.5851.00
92_I120_L1.5821.00
36_R51_R1.5561.00
89_A121_V1.5451.00
88_F108_F1.5441.00
38_A106_G1.5381.00
104_D113_S1.5251.00
11_L14_R1.5191.00
138_P142_R1.4791.00
85_L124_N1.4721.00
96_L99_G1.3941.00
55_V58_P1.3261.00
96_L117_S1.2831.00
32_P55_V1.2821.00
49_L52_P1.2711.00
145_S149_A1.2691.00
144_L148_D1.2541.00
89_A93_A1.2531.00
95_N116_I1.2441.00
152_G156_A1.2191.00
32_P36_R1.2191.00
40_A47_A1.2051.00
50_A54_A1.1821.00
103_I116_I1.1591.00
57_L87_L1.1581.00
32_P58_P1.1531.00
36_R40_A1.1511.00
118_W122_A1.1481.00
88_F92_I1.1451.00
17_L68_L1.1441.00
89_A125_L1.1391.00
21_F81_A1.1001.00
18_A69_L1.0961.00
40_A50_A1.0921.00
29_L62_L1.0901.00
15_L19_L1.0591.00
152_G155_A1.0561.00
68_L81_A1.0471.00
18_A22_A1.0361.00
25_A29_L1.0351.00
96_L101_R1.0331.00
104_D112_A1.0301.00
89_A124_N1.0291.00
157_A163_Y1.0251.00
145_S148_D1.0111.00
92_I95_N1.0111.00
120_L123_R1.0051.00
64_V67_A1.0041.00
77_A80_A0.9891.00
45_L48_A0.9821.00
84_L88_F0.9821.00
53_V87_L0.9801.00
95_N99_G0.9471.00
96_L116_I0.9341.00
92_I124_N0.9271.00
68_L78_A0.9261.00
92_I96_L0.9240.99
138_P143_P0.9110.99
156_A160_A0.9110.99
44_L91_A0.9100.99
24_A27_H0.9050.99
41_A103_I0.9040.99
121_V124_N0.9020.99
17_L81_A0.9010.99
91_A94_I0.8950.99
96_L100_R0.8920.99
95_N98_R0.8890.99
132_L136_A0.8790.99
42_Y91_A0.8760.99
96_L121_V0.8690.99
95_N103_I0.8620.99
82_A132_L0.8530.99
46_P49_L0.8500.99
140_A143_P0.8490.99
35_F54_A0.8450.99
34_G37_A0.8440.99
147_L150_L0.8420.99
124_N128_A0.8410.99
34_G106_G0.8410.99
102_D115_P0.8370.99
148_D151_T0.8350.99
35_F57_L0.8350.99
154_A157_A0.8210.99
148_D152_G0.8210.99
21_F64_V0.8170.99
58_P62_L0.8050.99
142_R146_L0.7990.99
83_A87_L0.7970.99
38_A41_A0.7930.98
121_V125_L0.7920.98
21_F65_A0.7900.98
150_L153_L0.7810.98
125_L129_A0.7700.98
82_A89_A0.7680.98
149_A152_G0.7660.98
29_L58_P0.7640.98
133_A137_L0.7360.97
17_L85_L0.7340.97
112_A116_I0.7300.97
116_I120_L0.7250.97
122_A126_V0.7220.97
96_L103_I0.7210.97
143_P147_L0.7180.97
60_A80_A0.7160.97
34_G38_A0.7160.97
86_L128_A0.7090.97
106_G114_Q0.7030.97
42_Y108_F0.7020.97
106_G120_L0.7010.97
52_P55_V0.6990.97
147_L151_T0.6980.97
154_A158_L0.6950.96
85_L127_L0.6900.96
137_L141_A0.6760.96
138_P141_A0.6750.96
9_V133_A0.6710.96
67_A70_L0.6680.96
21_F124_N0.6660.96
85_L89_A0.6650.95
34_G108_F0.6630.95
10_L14_R0.6630.95
36_R55_V0.6610.95
114_Q120_L0.6590.95
156_A161_L0.6580.95
33_A36_R0.6570.95
23_V27_H0.6460.95
151_T158_L0.6400.94
153_L157_A0.6390.94
150_L154_A0.6380.94
158_L164_L0.6370.94
18_A71_P0.6290.94
158_L163_Y0.6280.94
159_L163_Y0.6260.94
130_L134_V0.6250.94
21_F128_A0.6210.94
139_P143_P0.6170.93
126_V130_L0.6090.93
43_R46_P0.6070.93
42_Y92_I0.6000.92
79_L82_A0.5950.92
97_A118_W0.5940.92
76_A79_L0.5940.92
135_A139_P0.5930.92
32_P59_A0.5930.92
24_A88_F0.5890.92
28_K61_E0.5880.92
35_F58_P0.5870.91
67_A73_T0.5820.91
74_R78_A0.5790.91
142_R151_T0.5770.91
53_V58_P0.5740.91
102_D110_P0.5700.90
20_V88_F0.5690.90
27_H111_G0.5670.90
155_A159_L0.5660.90
41_A112_A0.5650.90
35_F91_A0.5640.90
114_Q117_S0.5640.90
13_A133_A0.5610.90
144_L152_G0.5590.89
43_R98_R0.5590.89
92_I123_R0.5570.89
81_A131_A0.5480.88
18_A72_A0.5480.88
71_P74_R0.5460.88
33_A37_A0.5460.88
139_P142_R0.5450.88
42_Y95_N0.5410.88
149_A156_A0.5400.88
91_A95_N0.5390.88
13_A75_R0.5390.88
78_A134_V0.5380.88
131_A135_A0.5360.87
101_R116_I0.5350.87
159_L164_L0.5330.87
128_A132_L0.5310.87
155_A158_L0.5310.87
56_L59_A0.5300.87
149_A157_A0.5290.87
94_I97_A0.5260.86
44_L94_I0.5240.86
39_L44_L0.5230.86
53_V57_L0.5220.86
89_A92_I0.5210.86
90_A94_I0.5190.86
32_P54_A0.5170.85
40_A100_R0.5160.85
149_A153_L0.5160.85
93_A96_L0.5150.85
57_L61_E0.5110.85
158_L162_L0.5100.85
16_L20_V0.5100.85
149_A154_A0.5100.85
29_L40_A0.5090.85
34_G114_Q0.5090.85
45_L50_A0.5070.84
100_R103_I0.5070.84
12_A155_A0.5060.84
153_L156_A0.5060.84
143_P146_L0.5050.84
75_R139_P0.5050.84
152_G160_A0.5040.84
97_A101_R0.5030.84
101_R118_W0.5020.84
17_L20_V0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a65A 2 0.5598 2.7 0.953 Contact Map
1yk1E 1 0.1087 2.2 0.954 Contact Map
2h3oA 1 0.2391 2 0.956 Contact Map
1yk0E 1 0.1087 1.5 0.959 Contact Map
4k1cA 4 0.9348 1.3 0.961 Contact Map
2l9uA 2 0.212 1.1 0.962 Contact Map
3giaA 1 0.875 1.1 0.962 Contact Map
1sf8A 5 0.2391 1 0.963 Contact Map
1m06J 1 0.0707 1 0.963 Contact Map
2mixA 1 0.1141 0.9 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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