DUF1444 - PFAM28P - GREMLIN Contacts

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DUF1444 - Protein of unknown function (DUF1444)

PFAM:	PF07285	Sequences: MTSKKMKKKLEERLKKEDRTFSFDREKDTLRIEHKETGKGVTISLPNIYAKYEEKKEKAIDEVVYYVEEALEAMEEEQSLEGDEKRIFPVIRSTSFPTETKEGKPLVYDEHTAETRIYYALDLGKSYRLIDEKMLEKEGWTEEELREIALFNLRSLPTEVKKDEVAGNDFYFLNANDGYDASRILNESFLKEMEAKVEGDMVVAVPHQDVLIIADIRNETGYDVLAQMTMKFFAEGRVPITALSFLYEDGELEPIFILAKNKPK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	264 (262)
Sequences:	566 (422)
Seq/√Len:	26.1
META:	0.468

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
202_V	214_A	5.284	1.00
198_E	217_R	4.546	1.00
109_D	146_R	4.537	1.00
231_K	235_E	4.201	1.00
3_S	28_D	3.819	1.00
202_V	225_L	3.722	1.00
201_M	213_I	3.658	1.00
9_K	12_E	3.626	1.00
8_K	11_E	3.336	1.00
6_M	49_Y	3.235	1.00
204_A	229_T	3.204	1.00
2_T	5_K	3.149	1.00
169_D	217_R	3.035	1.00
4_K	7_K	2.951	1.00
7_K	11_E	2.870	1.00
197_V	201_M	2.732	0.99
177_D	183_R	2.690	0.99
29_T	42_T	2.560	0.99
5_K	12_E	2.532	0.99
164_E	169_D	2.361	0.98
119_Y	146_R	2.359	0.98
107_V	135_L	2.330	0.98
173_L	189_F	2.254	0.98
122_D	179_Y	2.240	0.98
5_K	9_K	2.149	0.97
21_F	30_L	2.122	0.97
162_K	169_D	1.926	0.94
258_L	262_K	1.853	0.93
204_A	259_A	1.824	0.93
151_F	154_R	1.804	0.92
30_L	63_V	1.789	0.92
60_I	64_V	1.775	0.92
98_T	116_R	1.771	0.91
2_T	28_D	1.715	0.90
4_K	8_K	1.703	0.90
23_F	49_Y	1.687	0.89
177_D	180_D	1.668	0.89
28_D	46_P	1.615	0.87
133_K	136_E	1.614	0.87
82_G	138_E	1.599	0.87
189_F	213_I	1.579	0.86
153_L	197_V	1.569	0.85
16_K	19_R	1.560	0.85
244_S	259_A	1.559	0.85
11_E	25_R	1.546	0.85
147_E	151_F	1.511	0.83
202_V	246_L	1.506	0.83
58_K	251_E	1.503	0.83
11_E	15_K	1.486	0.82
4_K	22_S	1.479	0.82
200_D	246_L	1.460	0.81
132_E	136_E	1.457	0.81
49_Y	52_Y	1.446	0.80
31_R	40_G	1.443	0.80
92_R	181_A	1.428	0.80
135_L	145_L	1.426	0.79
241_T	245_F	1.412	0.79
209_D	236_G	1.402	0.78
21_F	29_T	1.382	0.77
178_G	183_R	1.370	0.77
168_N	218_N	1.367	0.76
153_L	262_K	1.360	0.76
246_L	259_A	1.332	0.74
48_I	63_V	1.321	0.74
62_E	66_Y	1.318	0.74
85_K	155_S	1.308	0.73
241_T	247_Y	1.300	0.73
84_E	138_E	1.256	0.70
114_E	245_F	1.252	0.70
153_L	158_T	1.246	0.69
4_K	26_E	1.244	0.69
190_L	201_M	1.235	0.69
9_K	13_R	1.235	0.69
3_S	262_K	1.231	0.68
251_E	258_L	1.228	0.68
2_T	7_K	1.228	0.68
18_D	35_K	1.227	0.68
92_R	129_L	1.225	0.68
61_D	64_V	1.214	0.67
184_I	203_V	1.213	0.67
7_K	19_R	1.212	0.67
3_S	6_M	1.212	0.67
73_A	78_Q	1.208	0.67
220_T	261_N	1.179	0.65
14_L	30_L	1.167	0.64
83_D	138_E	1.163	0.64
96_F	207_H	1.151	0.63
7_K	21_F	1.142	0.62
110_E	135_L	1.141	0.62
6_M	9_K	1.136	0.62
34_H	75_E	1.134	0.62
3_S	46_P	1.122	0.61
164_E	167_G	1.119	0.61
87_I	119_Y	1.106	0.60
197_V	262_K	1.095	0.59
12_E	15_K	1.095	0.59
2_T	19_R	1.092	0.59
80_L	138_E	1.090	0.59
30_L	47_N	1.089	0.59
119_Y	145_L	1.083	0.58
34_H	37_T	1.074	0.58
28_D	49_Y	1.072	0.57
218_N	225_L	1.071	0.57
11_E	21_F	1.070	0.57
22_S	35_K	1.069	0.57
207_H	232_F	1.067	0.57
141_T	144_E	1.061	0.57
121_L	157_P	1.060	0.57
17_E	35_K	1.043	0.55
215_D	222_Y	1.041	0.55
205_V	247_Y	1.041	0.55
197_V	215_D	1.041	0.55
15_K	24_D	1.032	0.55
8_K	20_T	1.032	0.55
108_Y	116_R	1.031	0.54
184_I	205_V	1.029	0.54
140_W	144_E	1.026	0.54
99_E	103_G	1.023	0.54
5_K	200_D	1.021	0.54
80_L	140_W	1.019	0.54
34_H	259_A	1.010	0.53
80_L	83_D	1.002	0.52
92_R	115_T	1.000	0.52
160_V	173_L	0.998	0.52
12_E	20_T	0.977	0.51
52_Y	56_K	0.977	0.51
158_T	173_L	0.976	0.50
90_V	168_N	0.975	0.50
9_K	23_F	0.975	0.50
24_D	27_K	0.973	0.50
181_A	209_D	0.972	0.50
3_S	49_Y	0.967	0.50
259_A	262_K	0.957	0.49
143_E	148_I	0.955	0.49
111_H	210_V	0.955	0.49
246_L	251_E	0.951	0.49
120_A	156_L	0.947	0.48
18_D	25_R	0.943	0.48
3_S	7_K	0.940	0.48
7_K	18_D	0.938	0.48
120_A	129_L	0.933	0.47
2_T	53_E	0.927	0.47
5_K	13_R	0.911	0.46
19_R	24_D	0.909	0.45
147_E	154_R	0.903	0.45
94_T	116_R	0.885	0.44
108_Y	184_I	0.883	0.44
91_I	94_T	0.881	0.43
183_R	211_L	0.875	0.43
120_A	187_E	0.873	0.43
15_K	18_D	0.872	0.43
44_S	47_N	0.872	0.43
47_N	258_L	0.871	0.43
11_E	19_R	0.867	0.42
117_I	185_L	0.865	0.42
21_F	25_R	0.855	0.42
11_E	22_S	0.854	0.41
90_V	207_H	0.853	0.41
111_H	114_E	0.852	0.41
19_R	34_H	0.849	0.41
6_M	47_N	0.848	0.41
82_G	183_R	0.848	0.41
60_I	67_V	0.845	0.41
44_S	52_Y	0.844	0.41
19_R	75_E	0.842	0.41
65_Y	69_E	0.837	0.40
90_V	221_G	0.836	0.40
129_L	208_Q	0.833	0.40
95_S	172_F	0.831	0.40
5_K	8_K	0.830	0.40
9_K	15_K	0.825	0.39
41_V	70_A	0.825	0.39
10_L	64_V	0.823	0.39
33_E	38_G	0.815	0.39
29_T	262_K	0.811	0.38
84_E	155_S	0.811	0.38
106_L	259_A	0.811	0.38
60_I	63_V	0.809	0.38
237_R	258_L	0.807	0.38
200_D	259_A	0.807	0.38
132_E	142_E	0.803	0.38
73_A	126_S	0.803	0.38
36_E	139_G	0.802	0.38
178_G	212_I	0.798	0.38
189_F	193_M	0.797	0.37
17_E	164_E	0.796	0.37
176_N	180_D	0.794	0.37
119_Y	204_A	0.791	0.37
15_K	139_G	0.787	0.37
11_E	30_L	0.786	0.37
64_V	68_E	0.785	0.37
199_G	202_V	0.785	0.37
204_A	214_A	0.785	0.37
193_M	203_V	0.783	0.37
22_S	173_L	0.780	0.36
100_T	175_A	0.778	0.36
8_K	21_F	0.770	0.36
23_F	198_E	0.767	0.35
228_M	232_F	0.765	0.35
92_R	112_T	0.765	0.35
11_E	26_E	0.760	0.35
150_L	153_L	0.759	0.35
95_S	223_D	0.756	0.35
35_K	133_K	0.754	0.35
128_R	261_N	0.752	0.34
64_V	67_V	0.752	0.34
117_I	218_N	0.750	0.34
129_L	238_V	0.750	0.34
48_I	261_N	0.747	0.34
19_R	38_G	0.745	0.34
83_D	88_F	0.743	0.34
2_T	16_K	0.740	0.34
144_E	258_L	0.740	0.34
46_P	49_Y	0.736	0.33
6_M	153_L	0.735	0.33
159_E	196_K	0.732	0.33
87_I	182_S	0.732	0.33
87_I	130_I	0.729	0.33
194_E	246_L	0.728	0.33
2_T	259_A	0.728	0.33
38_G	262_K	0.727	0.33
16_K	35_K	0.722	0.32
156_L	211_L	0.718	0.32
26_E	175_A	0.717	0.32
2_T	37_T	0.715	0.32
181_A	221_G	0.715	0.32
197_V	259_A	0.714	0.32
104_K	133_K	0.712	0.32
16_K	38_G	0.711	0.32
7_K	145_L	0.711	0.32
67_V	77_E	0.708	0.32
226_A	242_A	0.708	0.32
233_F	241_T	0.707	0.31
10_L	19_R	0.706	0.31
194_E	249_D	0.700	0.31
174_N	211_L	0.700	0.31
18_D	262_K	0.698	0.31
226_A	259_A	0.697	0.31
182_S	199_G	0.697	0.31
65_Y	73_A	0.691	0.30
112_T	115_T	0.690	0.30
190_L	226_A	0.689	0.30
66_Y	259_A	0.689	0.30
1_M	6_M	0.689	0.30
17_E	262_K	0.689	0.30
102_E	132_E	0.687	0.30
89_P	177_D	0.687	0.30
119_Y	185_L	0.684	0.30
66_Y	174_N	0.684	0.30
69_E	125_K	0.684	0.30
214_A	219_E	0.683	0.30
92_R	172_F	0.681	0.30
223_D	227_Q	0.678	0.30
93_S	126_S	0.677	0.30
4_K	25_R	0.677	0.30
3_S	47_N	0.675	0.29
20_T	27_K	0.671	0.29
132_E	204_A	0.670	0.29
112_T	177_D	0.670	0.29
246_L	250_G	0.669	0.29
111_H	232_F	0.668	0.29
208_Q	211_L	0.667	0.29
26_E	41_V	0.665	0.29
222_Y	227_Q	0.664	0.29
26_E	30_L	0.664	0.29
13_R	61_D	0.662	0.29
22_S	26_E	0.660	0.29
122_D	171_Y	0.659	0.28
114_E	223_D	0.658	0.28
126_S	154_R	0.652	0.28
92_R	177_D	0.652	0.28
154_R	188_S	0.651	0.28
111_H	115_T	0.651	0.28
9_K	18_D	0.651	0.28
21_F	260_K	0.649	0.28
3_S	36_E	0.647	0.28
11_E	14_L	0.644	0.28
117_I	205_V	0.644	0.28
151_F	188_S	0.641	0.27
6_M	259_A	0.641	0.27
73_A	123_L	0.640	0.27
148_I	153_L	0.639	0.27
12_E	22_S	0.639	0.27
104_K	135_L	0.639	0.27
201_M	220_T	0.639	0.27
7_K	15_K	0.635	0.27
9_K	20_T	0.635	0.27
146_R	258_L	0.635	0.27
146_R	238_V	0.629	0.27
23_F	28_D	0.623	0.26
80_L	255_I	0.621	0.26
10_L	34_H	0.621	0.26
6_M	10_L	0.619	0.26
110_E	116_R	0.618	0.26
131_D	147_E	0.618	0.26
8_K	17_E	0.617	0.26
2_T	63_V	0.613	0.26
53_E	97_P	0.612	0.26
111_H	205_V	0.610	0.26
207_H	210_V	0.609	0.26
113_A	170_F	0.607	0.25
183_R	190_L	0.606	0.25
96_F	127_Y	0.603	0.25
52_Y	140_W	0.603	0.25
5_K	17_E	0.601	0.25
87_I	145_L	0.601	0.25
53_E	258_L	0.601	0.25
4_K	11_E	0.598	0.25
119_Y	150_L	0.593	0.25
189_F	201_M	0.589	0.24
167_G	241_T	0.588	0.24
6_M	16_K	0.586	0.24
168_N	221_G	0.584	0.24
4_K	78_Q	0.583	0.24
164_E	198_E	0.583	0.24
24_D	166_A	0.582	0.24
41_V	125_K	0.578	0.24
7_K	22_S	0.577	0.24
4_K	17_E	0.576	0.24
130_I	212_I	0.575	0.24
112_T	172_F	0.575	0.24
7_K	17_E	0.574	0.24
88_F	120_A	0.574	0.24
235_E	250_G	0.572	0.24
209_D	212_I	0.571	0.23
111_H	179_Y	0.570	0.23
191_K	194_E	0.570	0.23
48_I	130_I	0.569	0.23
8_K	18_D	0.567	0.23
76_E	198_E	0.565	0.23
81_E	196_K	0.565	0.23
37_T	73_A	0.564	0.23
181_A	227_Q	0.564	0.23
38_G	51_K	0.563	0.23
127_Y	178_G	0.563	0.23
9_K	98_T	0.562	0.23
8_K	63_V	0.561	0.23
251_E	260_K	0.560	0.23
144_E	148_I	0.558	0.23
204_A	240_I	0.557	0.23
12_E	77_E	0.556	0.23
21_F	26_E	0.555	0.23
128_R	230_M	0.554	0.23
120_A	179_Y	0.552	0.22
230_M	242_A	0.552	0.22
218_N	223_D	0.551	0.22
92_R	183_R	0.549	0.22
39_K	43_I	0.548	0.22
96_F	129_L	0.546	0.22
7_K	45_L	0.544	0.22
239_P	245_F	0.542	0.22
74_M	103_G	0.541	0.22
60_I	66_Y	0.540	0.22
151_F	155_S	0.539	0.22
91_I	185_L	0.539	0.22
3_S	44_S	0.539	0.22
12_E	153_L	0.538	0.22
11_E	17_E	0.537	0.22
197_V	261_N	0.536	0.22
210_V	232_F	0.536	0.22
22_S	139_G	0.535	0.22
4_K	27_K	0.534	0.22
17_E	162_K	0.533	0.22
230_M	234_A	0.531	0.21
35_K	197_V	0.528	0.21
4_K	21_F	0.528	0.21
9_K	16_K	0.527	0.21
10_L	26_E	0.526	0.21
66_Y	70_A	0.525	0.21
69_E	203_V	0.525	0.21
27_K	46_P	0.524	0.21
146_R	187_E	0.523	0.21
227_Q	242_A	0.523	0.21
88_F	124_G	0.522	0.21
233_F	239_P	0.521	0.21
128_R	134_M	0.521	0.21
95_S	207_H	0.520	0.21
15_K	104_K	0.518	0.21
4_K	258_L	0.517	0.21
16_K	21_F	0.515	0.21
86_R	145_L	0.515	0.21
16_K	22_S	0.513	0.21
2_T	6_M	0.512	0.20
106_L	244_S	0.512	0.20
11_E	213_I	0.510	0.20
117_I	132_E	0.510	0.20
231_K	242_A	0.510	0.20
232_F	239_P	0.509	0.20
4_K	48_I	0.506	0.20
189_F	244_S	0.504	0.20
21_F	259_A	0.502	0.20
93_S	240_I	0.501	0.20
2_T	15_K	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3q4fC	2	0.3485	29.3	0.957	Contact Map
4pfuA	2	0.2197	14.2	0.962	Contact Map
4pfyA	1	0.2159	13.4	0.963	Contact Map
4uqwA	1	0.5492	9.6	0.965	Contact Map
1x4pA	1	0.1288	9.5	0.965	Contact Map
3czqA	3	0.7689	9.3	0.965	Contact Map
3vwbA	1	0.3409	7.7	0.967	Contact Map
3vbhD	3	0.0833	7.7	0.967	Contact Map
3g65A	1	0.8258	7.4	0.967	Contact Map
2x4kA	4	0.2348	6	0.968	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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