GREMLIN Database
BCHF - 2-vinyl bacteriochlorophyllide hydratase (BCHF)
PFAM: PF07284 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 139 (138)
Sequences: 1581 (796)
Seq/√Len: 67.8
META: 0.886

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_V59_V4.1831.00
61_Y99_T3.4651.00
12_S73_V3.0121.00
44_E47_A2.8061.00
39_Y116_M2.7071.00
68_A77_Q2.3951.00
48_A51_A2.3411.00
46_Y112_P2.2971.00
7_A11_A2.2581.00
110_L118_L2.2521.00
69_I73_V2.2301.00
47_A51_A2.2231.00
111_S114_G2.1881.00
104_A118_L2.1751.00
89_V93_L2.1011.00
54_V102_L2.0401.00
39_Y46_Y1.9771.00
46_Y50_T1.8841.00
104_A110_L1.8701.00
104_A115_Q1.8221.00
80_F92_M1.8151.00
5_E82_P1.8081.00
113_R117_L1.7951.00
68_A95_L1.7471.00
37_L41_A1.7111.00
58_L62_T1.6951.00
103_V107_T1.6500.99
59_V62_T1.6420.99
16_L20_V1.6410.99
53_I105_L1.6170.99
68_A78_Y1.6130.99
103_V109_A1.5930.99
85_F89_V1.5710.99
110_L114_G1.5460.99
131_A135_L1.5410.99
30_L34_A1.5390.99
50_T115_Q1.5380.99
114_G118_L1.5360.99
100_A118_L1.4700.99
38_R45_G1.4590.98
61_Y102_L1.4160.98
107_T110_L1.3770.98
2_T5_E1.3620.98
28_V55_V1.3510.97
29_F33_L1.3460.97
105_L115_Q1.3350.97
13_V16_L1.3110.97
24_L59_V1.2340.96
90_F93_L1.2330.96
39_Y50_T1.2250.96
29_F127_V1.2230.95
90_F128_I1.2140.95
26_F29_F1.1890.95
110_L115_Q1.1710.94
4_E7_A1.1510.94
50_T105_L1.1430.94
55_V59_V1.1430.94
54_V59_V1.1380.93
73_V77_Q1.1030.92
72_K75_F1.0970.92
36_V116_M1.0900.92
30_L33_L1.0890.92
50_T53_I1.0860.92
53_I101_Y1.0700.91
90_F125_A1.0640.91
38_R44_E1.0600.91
77_Q92_M1.0310.89
127_V131_A1.0280.89
29_F121_A1.0220.89
34_A38_R1.0180.89
16_L19_G1.0000.88
99_T102_L0.9890.87
112_P115_Q0.9430.85
114_G117_L0.9240.84
90_F95_L0.9170.83
92_M95_L0.9080.82
82_P85_F0.9040.82
69_I72_K0.8990.82
13_V73_V0.8780.80
31_V48_A0.8740.80
77_Q83_A0.8720.80
47_A50_T0.8690.80
90_F137_L0.8550.78
93_L125_A0.8440.78
103_V106_F0.8430.77
100_A104_A0.8350.77
13_V69_I0.8340.77
5_E8_R0.8320.77
73_V90_F0.8270.76
115_Q118_L0.8180.75
38_R42_T0.8170.75
131_A134_L0.8160.75
98_H120_L0.8130.75
100_A110_L0.7970.73
90_F131_A0.7960.73
12_S16_L0.7950.73
51_A55_V0.7880.73
117_L121_A0.7870.72
68_A83_A0.7840.72
104_A109_A0.7800.72
104_A114_G0.7790.72
121_A127_V0.7740.71
77_Q82_P0.7740.71
58_L106_F0.7670.71
72_K90_F0.7640.70
5_E76_G0.7630.70
23_P127_V0.7350.67
118_L122_A0.7310.67
95_L102_L0.7240.66
20_V24_L0.7230.66
93_L121_A0.7230.66
6_R10_D0.7180.65
11_A73_V0.7050.64
121_A124_A0.7050.64
129_N132_Q0.7040.64
54_V105_L0.7020.64
55_V58_L0.6940.63
45_G49_A0.6890.62
59_V95_L0.6880.62
46_Y116_M0.6870.62
50_T116_M0.6860.62
48_A55_V0.6830.62
34_A41_A0.6710.60
64_M79_L0.6690.60
13_V20_V0.6690.60
106_F109_A0.6660.60
59_V111_S0.6640.59
100_A103_V0.6630.59
29_F90_F0.6630.59
85_F92_M0.6600.59
50_T106_F0.6600.59
7_A13_V0.6580.59
69_I75_F0.6550.58
57_T91_S0.6510.58
104_A116_M0.6480.58
46_Y115_Q0.6480.58
80_F89_V0.6440.57
18_Q21_L0.6440.57
64_M91_S0.6400.57
39_Y112_P0.6390.56
72_K76_G0.6330.56
108_G111_S0.6330.56
125_A131_A0.6330.56
40_L113_R0.6270.55
38_R41_A0.6260.55
1_Y5_E0.6260.55
65_V68_A0.6200.54
110_L117_L0.6190.54
91_S119_A0.6180.54
69_I78_Y0.6160.54
60_L63_I0.6140.54
16_L23_P0.6100.53
54_V58_L0.6080.53
33_L127_V0.6070.53
33_L59_V0.6060.53
79_L91_S0.6020.52
51_A103_V0.6010.52
92_M96_A0.6000.52
7_A72_K0.6000.52
126_Y129_N0.5960.51
3_P7_A0.5960.51
5_E77_Q0.5960.51
33_L37_L0.5850.50
35_L38_R0.5820.50
13_V17_V0.5710.48
45_G48_A0.5690.48
33_L53_I0.5690.48
68_A90_F0.5650.48
20_V127_V0.5640.48
24_L85_F0.5630.47
65_V95_L0.5600.47
48_A113_R0.5590.47
27_L77_Q0.5590.47
122_A125_A0.5560.47
50_T101_Y0.5560.47
50_T107_T0.5500.46
27_L37_L0.5480.46
7_A106_F0.5460.45
101_Y105_L0.5440.45
20_V122_A0.5430.45
35_L52_S0.5370.44
27_L59_V0.5370.44
54_V119_A0.5360.44
90_F94_V0.5340.44
50_T62_T0.5310.44
4_E58_L0.5290.43
61_Y96_A0.5270.43
6_R11_A0.5260.43
107_T114_G0.5250.43
58_L95_L0.5230.43
111_S125_A0.5220.43
68_A92_M0.5220.43
34_A58_L0.5210.42
78_Y117_L0.5180.42
5_E13_V0.5170.42
34_A59_V0.5160.42
14_W22_A0.5160.42
94_V102_L0.5130.42
91_S130_A0.5100.41
118_L121_A0.5090.41
51_A78_Y0.5070.41
13_V103_V0.5050.41
106_F113_R0.5040.41
107_T111_S0.5020.40
36_V120_L0.5010.40
40_L116_M0.5000.40
64_M94_V0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4v194 1 0 9.8 0.961 Contact Map
4om9A 1 0.2302 6 0.965 Contact Map
1xwjB 1 0.1727 5.3 0.966 Contact Map
1vdaA 1 0.0863 3.8 0.968 Contact Map
3szeA 1 0.2518 2.3 0.971 Contact Map
3j5pB 3 0.9424 2 0.972 Contact Map
2lx0A 1 0.2302 2 0.972 Contact Map
4ne2A 2 0.3381 1.8 0.973 Contact Map
4j2lC 1 0.1583 1.7 0.973 Contact Map
3tqcA 2 0.3453 1.7 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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