GREMLIN Database
TrbH - Conjugal transfer protein TrbH
PFAM: PF07283 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 119 (107)
Sequences: 606 (438)
Seq/√Len: 42.3
META: 0.703

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_D102_Y5.6001.00
10_M91_L4.1181.00
79_D88_R3.7901.00
10_M35_F2.9741.00
20_P48_Y2.8971.00
48_Y56_T2.4861.00
36_G76_Y2.4061.00
11_V48_Y2.2361.00
10_M89_L2.1380.99
86_L112_A2.0050.99
36_G77_V1.6850.97
21_A52_E1.6570.97
18_Y79_D1.5650.96
23_T72_L1.4890.94
50_V78_V1.4330.93
33_D36_G1.4310.93
24_T49_A1.4230.93
26_N73_P1.4180.93
23_T33_D1.3870.92
105_T114_P1.3830.92
34_A38_A1.3770.91
14_L74_L1.3760.91
7_A13_R1.3680.91
32_S114_P1.2960.89
5_A92_Y1.2890.88
20_P23_T1.2650.87
36_G111_P1.1960.84
30_D116_S1.1950.84
7_A38_A1.1910.84
14_L48_Y1.1860.84
96_Q115_W1.1750.83
43_L91_L1.1710.83
78_V89_L1.1600.82
20_P112_A1.1520.82
114_P117_R1.1430.81
7_A83_G1.1360.81
29_Q77_V1.1240.80
43_L47_G1.1060.79
13_R16_E1.0810.78
100_R111_P1.0680.77
10_M115_W1.0680.77
36_G94_G1.0600.76
58_K61_K1.0600.76
58_K89_L1.0590.76
26_N49_A1.0510.76
19_P76_Y1.0440.75
39_L78_V1.0320.74
109_A118_K1.0270.74
25_F74_L1.0270.74
54_Q57_D1.0250.74
74_L112_A1.0220.74
72_L80_Q1.0160.73
15_A46_W1.0160.73
33_D115_W1.0120.73
17_L87_Y1.0110.73
36_G39_L1.0070.72
105_T108_G1.0060.72
6_I91_L1.0040.72
6_I89_L1.0010.72
48_Y103_T1.0000.72
29_Q33_D0.9970.72
40_E52_E0.9790.70
87_Y99_S0.9700.70
18_Y98_L0.9670.69
18_Y23_T0.9510.68
14_L95_S0.9460.68
6_I10_M0.9330.67
44_R52_E0.9300.66
52_E115_W0.9270.66
14_L93_V0.9130.65
84_Q97_S0.9030.64
94_G102_Y0.9030.64
5_A8_G0.9000.64
113_G117_R0.8760.62
21_A96_Q0.8650.61
25_F93_V0.8570.60
10_M13_R0.8430.59
55_K58_K0.8360.58
33_D40_E0.8290.57
85_V94_G0.8250.57
26_N71_G0.8240.57
28_K98_L0.8230.57
73_P94_G0.8210.57
7_A11_V0.8200.57
51_V116_S0.8000.55
24_T105_T0.7940.54
8_G15_A0.7750.52
40_E86_L0.7680.52
94_G97_S0.7680.52
18_Y93_V0.7660.51
95_S102_Y0.7660.51
7_A61_K0.7610.51
4_S114_P0.7570.51
30_D54_Q0.7570.51
73_P83_G0.7530.50
13_R91_L0.7460.50
33_D97_S0.7440.49
50_V101_A0.7330.48
6_I9_D0.7300.48
35_F99_S0.7300.48
23_T107_G0.7290.48
11_V20_P0.7260.48
10_M113_G0.7240.48
18_Y96_Q0.7240.48
41_A101_A0.7220.47
10_M79_D0.7160.47
11_V36_G0.7130.46
13_R86_L0.7090.46
29_Q39_L0.7040.46
56_T61_K0.6940.45
37_T84_Q0.6930.45
48_Y98_L0.6810.43
52_E99_S0.6630.42
7_A81_F0.6590.41
27_L104_V0.6590.41
49_A75_A0.6570.41
19_P33_D0.6410.40
81_F99_S0.6400.40
76_Y107_G0.6380.40
41_A46_W0.6370.39
9_D48_Y0.6360.39
86_L92_Y0.6340.39
8_G42_A0.6320.39
6_I78_V0.6300.39
21_A24_T0.6240.38
14_L25_F0.6240.38
42_A82_D0.6020.36
25_F30_D0.6010.36
13_R87_Y0.6010.36
37_T102_Y0.6000.36
45_G70_P0.5880.35
39_L47_G0.5860.35
58_K94_G0.5830.35
7_A35_F0.5820.35
25_F87_Y0.5770.34
17_L98_L0.5720.34
44_R79_D0.5700.34
4_S8_G0.5700.34
101_A106_N0.5700.34
22_K32_S0.5680.33
44_R100_R0.5600.33
81_F104_V0.5570.33
14_L24_T0.5560.32
56_T59_A0.5560.32
49_A74_L0.5520.32
17_L93_V0.5440.31
6_I35_F0.5440.31
32_S54_Q0.5350.31
11_V42_A0.5340.31
78_V87_Y0.5330.31
55_K112_A0.5290.30
27_L51_V0.5240.30
40_E93_V0.5210.30
16_E50_V0.5210.30
21_A25_F0.5180.29
11_V43_L0.5120.29
75_A101_A0.5080.29
72_L103_T0.5070.29
58_K79_D0.5040.28
12_S48_Y0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3p73A 1 0.4286 31.9 0.898 Contact Map
3it8D 1 0.4034 31 0.899 Contact Map
4l4vA 1 0.4202 30.2 0.899 Contact Map
4g59A 1 0.3193 29.8 0.899 Contact Map
1t7vA 1 0.4202 29.3 0.9 Contact Map
4lzpB 2 0.7563 26.1 0.902 Contact Map
4g43A 1 0.4118 24.9 0.904 Contact Map
3fruA 1 0.4286 20.5 0.907 Contact Map
2wy3A 1 0.4202 19.7 0.908 Contact Map
3d2uA 2 0.4034 18.2 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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