GREMLIN Database
SapC - SapC
PFAM: PF07277 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 221 (220)
Sequences: 6901 (5156)
Seq/√Len: 347.6
META: 0.864

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_E184_D3.3811.00
193_D197_L3.0681.00
28_L36_A3.0561.00
196_L200_H2.9651.00
152_A156_E2.7901.00
33_F55_P2.7751.00
192_D195_A2.7491.00
121_D125_E2.4671.00
157_L195_A2.3311.00
158_D187_K2.2831.00
128_P132_N2.2671.00
186_E190_A2.2531.00
8_D113_E2.1671.00
53_F181_Y2.0961.00
210_A213_A2.0921.00
155_A158_D2.0711.00
193_D201_R2.0331.00
70_D74_R1.9701.00
197_L201_R1.9621.00
125_E131_K1.9091.00
168_T174_P1.8881.00
26_V59_L1.8681.00
2_N5_R1.8421.00
153_A157_L1.8361.00
153_A156_E1.8351.00
52_E148_R1.7831.00
198_E202_S1.7651.00
135_E138_E1.7261.00
44_F211_H1.6821.00
157_L199_L1.6791.00
62_R65_E1.6421.00
118_P122_E1.6091.00
200_H205_L1.6021.00
153_A198_E1.5891.00
135_E139_E1.5881.00
138_E142_A1.5811.00
128_P131_K1.5801.00
153_A204_Y1.5731.00
31_A143_G1.5701.00
12_R115_E1.5541.00
10_R118_P1.5521.00
199_L204_Y1.5511.00
195_A198_E1.5351.00
39_E78_R1.5341.00
38_R217_N1.5241.00
9_L113_E1.4991.00
30_A147_T1.4871.00
22_N64_G1.4791.00
150_F208_I1.4551.00
40_Y68_F1.4361.00
154_L208_I1.4231.00
196_L205_L1.3651.00
193_D196_L1.3551.00
197_L200_H1.3541.00
150_F154_L1.3511.00
36_A79_Y1.3501.00
129_Y133_I1.3471.00
131_K135_E1.3431.00
33_F42_I1.3421.00
3_S125_E1.3401.00
126_P131_K1.3361.00
217_N220_R1.3261.00
5_R106_E1.3051.00
183_V208_I1.3041.00
28_L57_A1.3001.00
211_H215_L1.2901.00
43_V180_F1.2751.00
145_Q148_R1.2691.00
92_A103_C1.2591.00
53_F155_A1.2571.00
126_P134_L1.2511.00
37_A213_A1.2431.00
150_F204_Y1.2431.00
102_L134_L1.2391.00
55_P151_C1.2381.00
13_P117_E1.2271.00
26_V84_V1.2221.00
45_A56_V1.2221.00
82_A136_F1.2171.00
10_R115_E1.2151.00
52_E152_A1.2021.00
166_D174_P1.2001.00
28_L42_I1.1971.00
11_V129_Y1.1921.00
185_E212_L1.1911.00
148_R152_A1.1861.00
85_R136_F1.1741.00
126_P130_L1.1691.00
46_K155_A1.1611.00
132_N135_E1.1581.00
83_Y140_F1.1551.00
185_E206_P1.1481.00
153_A202_S1.1461.00
100_L141_E1.1401.00
44_F160_L1.1361.00
155_A181_Y1.1301.00
166_D176_R1.1261.00
41_P68_F1.1161.00
102_L137_L1.1131.00
149_A152_A1.1081.00
139_E143_G1.1051.00
206_P209_Y1.1051.00
26_V83_Y1.1041.00
185_E189_R1.0891.00
162_P181_Y1.0891.00
60_G67_L1.0881.00
30_A207_L1.0731.00
58_L218_F1.0731.00
29_T147_T1.0681.00
163_F182_T1.0631.00
193_D200_H1.0591.00
161_E182_T1.0521.00
62_R173_E1.0511.00
156_E198_E1.0441.00
141_E145_Q1.0421.00
189_R203_G1.0421.00
157_L198_E1.0421.00
71_E74_R1.0281.00
206_P210_A1.0271.00
164_E176_R1.0271.00
85_R132_N1.0271.00
4_E7_A1.0261.00
102_L130_L1.0241.00
12_R112_S0.9971.00
42_I55_P0.9961.00
39_E220_R0.9941.00
62_R175_L0.9901.00
46_K53_F0.9891.00
131_K134_L0.9851.00
154_L183_V0.9771.00
108_S111_V0.9671.00
153_A199_L0.9671.00
192_D197_L0.9671.00
46_K181_Y0.9631.00
187_K190_A0.9611.00
143_G146_R0.9601.00
10_R116_G0.9571.00
8_D118_P0.9521.00
38_R216_G0.9491.00
86_R136_F0.9471.00
142_A146_R0.9421.00
200_H209_Y0.9331.00
43_V56_V0.9321.00
195_A199_L0.9271.00
189_R200_H0.9191.00
25_A56_V0.9141.00
164_E178_T0.9101.00
82_A85_R0.9101.00
182_T211_H0.9091.00
59_L84_V0.9061.00
160_L211_H0.8991.00
117_E129_Y0.8921.00
184_D187_K0.8921.00
121_D127_S0.8911.00
104_I119_L0.8901.00
9_L104_I0.8881.00
89_F133_I0.8861.00
141_E144_L0.8831.00
134_L138_E0.8801.00
23_V84_V0.8801.00
147_T151_C0.8771.00
10_R114_E0.8771.00
112_S115_E0.8721.00
69_V73_G0.8711.00
70_D76_D0.8681.00
20_A69_V0.8551.00
152_A155_A0.8511.00
91_L102_L0.8421.00
83_Y86_R0.8401.00
129_Y132_N0.8361.00
156_E195_A0.8361.00
139_E142_A0.8351.00
59_L75_W0.8281.00
209_Y212_L0.8271.00
188_L212_L0.8261.00
24_N63_E0.8241.00
163_F180_F0.8231.00
162_P179_G0.8171.00
17_A20_A0.8081.00
18_A21_A0.8041.00
194_E197_L0.8021.00
34_A210_A0.7941.00
35_A38_R0.7881.00
43_V58_L0.7851.00
31_A146_R0.7831.00
36_A57_A0.7781.00
53_F160_L0.7781.00
69_V75_W0.7771.00
155_A160_L0.7731.00
60_G65_E0.7711.00
24_N64_G0.7651.00
86_R140_F0.7641.00
121_D128_P0.7631.00
75_W80_V0.7611.00
40_Y57_A0.7591.00
11_V111_V0.7521.00
34_A185_E0.7441.00
3_S7_A0.7411.00
36_A42_I0.7340.99
198_E201_R0.7320.99
79_Y85_R0.7320.99
150_F207_L0.7320.99
55_P147_T0.7290.99
10_R117_E0.7240.99
46_K51_G0.7210.99
51_G155_A0.7200.99
46_K50_G0.7170.99
151_C155_A0.7160.99
40_Y77_A0.7160.99
154_L158_D0.7120.99
91_L137_L0.7120.99
146_R149_A0.7100.99
186_E189_R0.7100.99
36_A39_E0.7100.99
43_V218_F0.7090.99
39_E77_A0.7080.99
208_I211_H0.7050.99
145_Q149_A0.7050.99
44_F151_C0.7040.99
94_G97_G0.7030.99
35_A216_G0.7010.99
149_A204_Y0.6980.99
188_L208_I0.6920.99
95_E98_D0.6900.99
199_L208_I0.6900.99
44_F55_P0.6900.99
142_A145_Q0.6870.99
188_L209_Y0.6840.99
9_L111_V0.6800.99
196_L209_Y0.6790.99
118_P127_S0.6790.99
93_A97_G0.6760.99
29_T140_F0.6760.99
29_T143_G0.6740.99
27_P83_Y0.6740.99
94_G99_E0.6690.99
204_Y207_L0.6640.99
119_L130_L0.6590.99
149_A202_S0.6580.99
183_V211_H0.6570.99
161_E187_K0.6550.99
26_V57_A0.6550.99
10_R112_S0.6540.99
3_S126_P0.6540.99
183_V188_L0.6530.99
12_R15_D0.6530.99
20_A84_V0.6510.99
111_V119_L0.6500.99
29_T144_L0.6450.99
27_P30_A0.6380.99
87_Y105_D0.6350.99
208_I212_L0.6340.99
60_G66_N0.6340.99
104_I111_V0.6330.99
205_L209_Y0.6320.98
53_F151_C0.6300.98
185_E213_A0.6290.98
78_R220_R0.6280.98
36_A40_Y0.6180.98
30_A150_F0.6170.98
43_V163_F0.6170.98
79_Y82_A0.6150.98
191_L199_L0.6130.98
43_V215_L0.6130.98
41_P218_F0.6120.98
37_A42_I0.6090.98
169_L175_L0.6020.98
90_L103_C0.6020.98
175_L178_T0.6010.98
20_A75_W0.5930.98
192_D198_E0.5920.98
133_I137_L0.5900.98
127_S130_L0.5880.98
16_G19_F0.5860.98
144_L148_R0.5860.98
165_L218_F0.5840.97
189_R206_P0.5810.97
9_L106_E0.5780.97
24_N58_L0.5780.97
71_E76_D0.5780.97
34_A213_A0.5770.97
160_L181_Y0.5750.97
91_L100_L0.5730.97
2_N7_A0.5730.97
153_A195_A0.5730.97
188_L205_L0.5710.97
185_E216_G0.5700.97
10_R119_L0.5690.97
188_L200_H0.5690.97
35_A219_R0.5680.97
93_A98_D0.5640.97
130_L137_L0.5640.97
169_L172_G0.5630.97
133_I136_F0.5620.97
161_E186_E0.5540.97
199_L202_S0.5510.96
3_S124_G0.5500.96
40_Y84_V0.5470.96
86_R90_L0.5430.96
9_L109_P0.5410.96
185_E209_Y0.5400.96
45_A54_V0.5360.96
31_A139_E0.5340.96
34_A38_R0.5340.96
40_Y78_R0.5320.96
202_S207_L0.5290.96
106_E113_E0.5290.96
15_D74_R0.5270.95
16_G74_R0.5260.95
12_R113_E0.5260.95
169_L173_E0.5240.95
41_P57_A0.5240.95
40_Y80_V0.5230.95
183_V212_L0.5210.95
169_L174_P0.5200.95
94_G98_D0.5180.95
61_L167_I0.5170.95
143_G147_T0.5150.95
5_R9_L0.5140.95
39_E68_F0.5130.95
52_E155_A0.5100.95
164_E174_P0.5090.95
189_R196_L0.5080.94
22_N65_E0.5070.94
25_A58_L0.5070.94
121_D131_K0.5060.94
34_A216_G0.5040.94
168_T172_G0.5020.94
85_R133_I0.5020.94
20_A59_L0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a04A 2 0.2443 21.3 0.949 Contact Map
3jxeA 2 0.276 16.4 0.951 Contact Map
3tzeA 2 0.19 12.5 0.954 Contact Map
3hv0A 2 0.1946 12.4 0.954 Contact Map
2nwtA 2 0.3077 9.9 0.956 Contact Map
3khyA 2 0.5158 9.5 0.956 Contact Map
4j76A 2 0.2081 9.4 0.956 Contact Map
3i05A 2 0.2036 7 0.959 Contact Map
3ayhA 1 0.4932 6.6 0.959 Contact Map
2ip1A 1 0.1765 6.3 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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