GREMLIN Database
DUF1440 - Protein of unknown function (DUF1440)
PFAM: PF07274 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 135 (128)
Sequences: 806 (543)
Seq/√Len: 48.0
META: 0.68

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_L123_L4.6961.00
75_A82_T4.6941.00
87_A127_L3.4201.00
98_H122_E3.1701.00
33_Q107_L2.6031.00
69_A72_G2.3321.00
110_P113_E2.2701.00
118_E122_E2.2161.00
27_P30_L2.2111.00
27_P31_A2.1601.00
118_E121_S1.9310.99
3_S6_V1.8590.99
108_S114_Q1.8290.99
97_T100_G1.8290.99
75_A81_I1.8050.99
4_A8_W1.7520.99
9_G105_L1.7430.99
99_E119_H1.7000.98
5_A8_W1.6490.98
29_V32_E1.6060.97
27_P60_H1.6020.97
98_H114_Q1.5640.97
84_W87_A1.5610.97
91_L127_L1.5450.97
36_I40_L1.5380.97
129_W133_I1.5090.96
63_F121_S1.5020.96
89_F93_V1.4760.96
17_R21_R1.4530.95
94_W99_E1.4270.95
98_H121_S1.4240.95
104_A134_E1.3950.94
106_G109_P1.3940.94
88_A93_V1.3610.93
28_A56_S1.3490.93
18_T21_R1.3120.92
114_Q118_E1.2860.91
93_V129_W1.2640.91
8_W12_V1.2470.90
114_Q121_S1.2260.89
69_A73_A1.1980.88
63_F97_T1.1790.87
111_P119_H1.1700.87
74_L78_F1.1260.85
5_A13_I1.1160.84
6_V14_L1.1090.84
8_W13_I1.1040.83
74_L81_I1.1010.83
119_H123_L1.1000.83
31_A35_G1.0790.82
98_H119_H1.0550.81
73_A77_Y1.0480.80
32_E36_I1.0450.80
68_G133_I1.0430.80
121_S125_G1.0240.79
52_L57_L1.0220.78
114_Q122_E1.0210.78
7_K11_E1.0110.78
46_T49_G1.0050.77
122_E125_G0.9900.76
51_Q113_E0.9880.76
3_S54_W0.9770.75
114_Q117_R0.9750.75
60_H126_H0.9700.75
71_Y76_E0.9700.75
30_L33_Q0.9620.74
30_L34_L0.9600.74
66_A69_A0.9480.73
101_L105_L0.9440.73
31_A102_L0.9430.73
26_P29_V0.9390.72
27_P98_H0.9270.71
92_A96_A0.9260.71
72_G76_E0.9140.70
72_G106_G0.9040.69
21_R25_P0.9020.69
97_T101_L0.8850.68
92_A95_A0.8810.67
17_R27_P0.8810.67
66_A111_P0.8800.67
46_T70_A0.8750.67
95_A99_E0.8720.66
99_E123_L0.8690.66
8_W134_E0.8690.66
119_H122_E0.8640.66
48_S52_L0.8550.65
35_G40_L0.8550.65
109_P114_Q0.8510.65
76_E82_T0.8450.64
49_G96_A0.8430.64
60_H63_F0.8410.64
12_V22_P0.8370.63
124_A128_V0.8360.63
8_W56_S0.8280.62
91_L115_P0.8200.62
30_L107_L0.8150.61
83_L88_A0.7990.60
28_A32_E0.7960.59
29_V56_S0.7890.59
31_A59_V0.7840.58
77_Y82_T0.7780.58
88_A92_A0.7680.57
98_H118_E0.7670.57
74_L109_P0.7580.56
102_L118_E0.7570.56
61_F107_L0.7540.55
3_S12_V0.7540.55
32_E106_G0.7480.55
69_A88_A0.7470.55
41_T44_T0.7470.55
71_Y134_E0.7450.54
119_H129_W0.7440.54
4_A61_F0.7420.54
53_P57_L0.7370.54
95_A100_G0.7350.53
83_L93_V0.7350.53
114_Q119_H0.7340.53
87_A131_W0.7290.53
74_L80_K0.7190.52
4_A10_A0.7180.52
46_T51_Q0.7140.51
59_V98_H0.7110.51
47_Y52_L0.7070.51
11_E16_P0.7060.50
78_F81_I0.7010.50
64_G69_A0.7000.50
46_T50_Q0.6990.50
115_P127_L0.6930.49
72_G89_F0.6880.49
68_G80_K0.6810.48
59_V97_T0.6800.48
116_A120_A0.6780.48
73_A79_P0.6780.48
102_L108_S0.6770.48
64_G68_G0.6750.47
76_E79_P0.6690.47
25_P28_A0.6690.47
85_Q134_E0.6680.47
117_R125_G0.6660.46
115_P123_L0.6640.46
16_P71_Y0.6570.46
79_P91_L0.6560.45
3_S94_W0.6550.45
62_G112_W0.6490.45
58_A67_F0.6480.45
101_L107_L0.6430.44
66_A100_G0.6410.44
67_F93_V0.6390.44
28_A49_G0.6340.43
84_W109_P0.6330.43
45_Y64_G0.6320.43
14_L68_G0.6300.43
36_I58_A0.6280.43
66_A95_A0.6270.43
4_A64_G0.6230.42
19_P22_P0.6220.42
72_G85_Q0.6220.42
26_P122_E0.6210.42
3_S132_T0.6200.42
87_A91_L0.6200.42
30_L114_Q0.6140.41
11_E15_P0.6130.41
70_A89_F0.6100.41
63_F98_H0.6080.41
84_W88_A0.6040.40
85_Q100_G0.6040.40
14_L78_F0.6020.40
16_P20_G0.6000.40
29_V107_L0.5880.39
76_E92_A0.5870.39
5_A14_L0.5870.39
67_F85_Q0.5810.38
56_S61_F0.5750.38
67_F129_W0.5730.37
85_Q88_A0.5660.37
48_S66_A0.5600.36
26_P118_E0.5480.35
73_A76_E0.5470.35
61_F119_H0.5360.34
73_A92_A0.5350.34
93_V97_T0.5310.34
94_W123_L0.5180.32
108_S121_S0.5170.32
22_P25_P0.5170.32
39_D105_L0.5150.32
102_L128_V0.5150.32
25_P129_W0.5120.32
85_Q104_A0.5120.32
130_G133_I0.5110.32
99_E108_S0.5030.31
100_G122_E0.5010.31
99_E122_E0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aw6A 2 0.9778 6.5 0.937 Contact Map
4il3A 1 0.9926 4.9 0.941 Contact Map
3kv9A 2 0.3333 2.7 0.948 Contact Map
1iynA 1 0.1778 1.9 0.952 Contact Map
2ln3A 1 0.2296 1.6 0.954 Contact Map
3vw4A 1 0.3481 1.5 0.955 Contact Map
3kv4A 1 0.3556 1.5 0.955 Contact Map
4myvA 1 0 1.4 0.956 Contact Map
2kegA 1 0.237 1.4 0.956 Contact Map
2gj7F 1 0.1037 1.3 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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