GREMLIN Database
HemY_N - HemY protein N-terminus
PFAM: PF07219 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 107 (106)
Sequences: 12349 (7907)
Seq/√Len: 767.9
META: 0.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_F31_Y2.9391.00
3_V19_A2.7841.00
79_E106_Q2.1761.00
14_T18_V2.1071.00
65_R81_L2.0061.00
53_R57_R1.9611.00
6_V11_R1.9031.00
74_D77_R1.8901.00
69_A74_D1.8901.00
31_Y34_L1.8671.00
31_Y35_R1.8631.00
61_A65_R1.8001.00
79_E83_A1.7761.00
77_R81_L1.7641.00
35_R39_A1.7481.00
4_L13_E1.7371.00
4_L11_R1.7111.00
69_A81_L1.7081.00
37_L41_L1.6831.00
5_I19_A1.5831.00
39_A46_R1.5411.00
70_L98_L1.5211.00
59_G85_A1.5141.00
2_Y13_E1.5041.00
18_V22_A1.4781.00
38_R42_R1.4571.00
15_S18_V1.4111.00
68_I72_E1.4051.00
27_F30_L1.3811.00
35_R38_R1.3761.00
82_A98_L1.3401.00
63_L95_A1.3121.00
2_Y6_V1.3081.00
81_L84_R1.3051.00
75_W102_A1.3051.00
47_V51_R1.2671.00
7_W16_L1.2521.00
41_L44_P1.2341.00
23_L27_F1.2271.00
64_T68_I1.2191.00
53_R56_R1.2141.00
56_R60_R1.2101.00
50_W53_R1.2051.00
84_R88_L1.1801.00
22_A26_L1.1731.00
66_G82_A1.1701.00
49_R53_R1.1671.00
42_R46_R1.1671.00
39_A43_L1.1641.00
99_A102_A1.1641.00
28_V32_L1.1511.00
14_T19_A1.1511.00
26_L30_L1.1401.00
86_A99_A1.1181.00
83_A86_A1.1111.00
101_Q105_L1.0971.00
59_G89_L1.0711.00
27_F34_L1.0461.00
82_A102_A1.0191.00
85_A95_A1.0181.00
62_A85_A1.0161.00
44_P47_V1.0101.00
66_G78_A1.0041.00
45_R49_R0.9991.00
83_A87_R0.9971.00
55_R88_L0.9851.00
48_R52_R0.9691.00
40_L44_P0.9431.00
34_L38_R0.9421.00
57_R61_A0.9411.00
76_A79_E0.9381.00
51_R55_R0.9351.00
46_R49_R0.9221.00
50_W54_R0.9181.00
69_A77_R0.9181.00
19_A23_L0.9141.00
46_R50_W0.9041.00
62_A84_R0.8911.00
52_R56_R0.8911.00
71_A101_Q0.8821.00
60_R90_E0.8811.00
86_A90_E0.8771.00
70_L105_L0.8601.00
62_A81_L0.8571.00
60_R64_T0.8471.00
25_L28_V0.8431.00
58_R61_A0.8321.00
101_Q104_Q0.8261.00
75_W79_E0.7961.00
68_I71_A0.7901.00
6_V9_G0.7761.00
70_L78_A0.7581.00
47_V50_W0.7541.00
66_G70_L0.7501.00
91_A94_L0.7411.00
4_L8_G0.7401.00
14_T22_A0.7351.00
93_P96_L0.7291.00
7_W17_N0.7161.00
31_Y38_R0.7141.00
89_L92_P0.7071.00
10_Y14_T0.7051.00
54_R58_R0.6981.00
39_A42_R0.6881.00
91_A95_A0.6871.00
36_L40_L0.6871.00
93_P104_Q0.6831.00
92_P95_A0.6811.00
32_L36_L0.6751.00
13_E17_N0.6721.00
70_L102_A0.6671.00
63_L67_L0.6631.00
43_L47_V0.6621.00
18_V21_L0.6561.00
45_R48_R0.6551.00
8_G11_R0.6551.00
33_L37_L0.6551.00
5_I12_I0.6541.00
17_N20_V0.6531.00
59_G95_A0.6501.00
43_L46_R0.6391.00
34_L37_L0.6371.00
96_L99_A0.6301.00
8_G12_I0.6221.00
8_G16_L0.6171.00
51_R54_R0.6161.00
81_L85_A0.6031.00
4_L15_S0.6011.00
10_Y22_A0.5981.00
22_A25_L0.5961.00
67_L94_L0.5941.00
86_A96_L0.5941.00
3_V16_L0.5911.00
58_R88_L0.5851.00
8_G14_T0.5791.00
40_L43_L0.5741.00
59_G62_A0.5611.00
30_L34_L0.5531.00
28_V31_Y0.5501.00
49_R52_R0.5501.00
14_T17_N0.5461.00
64_T91_A0.5441.00
5_I16_L0.5431.00
5_I8_G0.5401.00
7_W12_I0.5381.00
17_N21_L0.5321.00
98_L105_L0.5301.00
24_L28_V0.5251.00
59_G88_L0.5231.00
34_L42_R0.5201.00
47_V54_R0.5191.00
9_G14_T0.5141.00
32_L35_R0.5111.00
79_E103_A0.5101.00
63_L70_L0.5091.00
66_G98_L0.5071.00
99_A103_A0.5071.00
86_A89_L0.5061.00
42_R45_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cgwA 1 0.5981 80.7 0.792 Contact Map
4bujB 1 0.5047 78.7 0.796 Contact Map
2xevA 1 0.4579 76.8 0.8 Contact Map
1w3bA 2 0.4393 75.8 0.802 Contact Map
2c2lA 1 0.486 75 0.803 Contact Map
2gw1A 2 0.4953 75 0.803 Contact Map
3urzA 1 0.4766 74.9 0.803 Contact Map
2kc7A 1 0.4486 74.9 0.803 Contact Map
4u04A 2 0.4673 73.6 0.805 Contact Map
4i2zA 1 0.486 73.4 0.805 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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