GREMLIN Database
DUF1415 - Protein of unknown function (DUF1415)
PFAM: PF07209 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 171 (169)
Sequences: 4758 (3377)
Seq/√Len: 259.7
META: 0.864

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_L64_I2.8061.00
37_S48_D2.6451.00
34_Y70_I2.5741.00
93_E98_E2.5691.00
65_E139_S2.5231.00
57_A101_L2.4941.00
24_K28_V2.4461.00
15_I27_H2.3441.00
45_L71_H2.2851.00
144_V150_P2.2111.00
11_E27_H2.2061.00
115_T121_E2.0491.00
6_T131_M2.0341.00
88_A103_I2.0211.00
99_G137_E1.9341.00
33_R52_E1.9291.00
85_L105_S1.8701.00
121_E158_I1.8121.00
33_R64_I1.8011.00
166_L170_Q1.7141.00
33_R55_L1.7101.00
27_H32_I1.6921.00
19_L161_L1.6561.00
52_E55_L1.6541.00
55_L59_A1.6431.00
27_H34_Y1.6191.00
8_R12_R1.6091.00
160_T164_L1.5881.00
10_L27_H1.5811.00
159_E163_R1.5111.00
50_L95_L1.4751.00
50_L91_L1.4491.00
52_E67_T1.4441.00
115_T122_N1.4431.00
121_E162_R1.4401.00
140_I144_V1.4361.00
152_A155_E1.4341.00
59_A63_E1.4211.00
71_H74_V1.4031.00
41_D44_A1.4001.00
135_L140_I1.3981.00
111_Q115_T1.3831.00
5_A129_Y1.3651.00
141_E145_A1.3631.00
120_I166_L1.3631.00
81_Y131_M1.3591.00
120_I123_Y1.3571.00
105_S110_Y1.3421.00
7_R30_G1.3361.00
40_T73_N1.3271.00
13_A169_W1.3251.00
156_R160_T1.3241.00
10_L68_L1.3171.00
119_D162_R1.3141.00
155_E159_E1.3021.00
75_L84_F1.2991.00
150_P153_I1.2811.00
160_T163_R1.2711.00
124_T161_L1.2451.00
115_T119_D1.2261.00
165_G168_G1.2241.00
54_E57_A1.1891.00
111_Q117_P1.1851.00
31_Q65_E1.1841.00
144_V147_F1.1791.00
123_Y166_L1.1711.00
26_V65_E1.1711.00
81_Y105_S1.1581.00
48_D51_A1.1581.00
97_L101_L1.1431.00
10_L15_I1.1261.00
7_R34_Y1.1191.00
79_L83_D1.1141.00
147_F154_P1.1121.00
35_V52_E1.1121.00
47_E51_A1.1111.00
147_F152_A1.1051.00
57_A97_L1.1031.00
92_L103_I1.1001.00
101_L134_L1.0931.00
45_L75_L1.0911.00
13_A19_L1.0891.00
81_Y110_Y1.0871.00
38_E73_N1.0851.00
54_E58_A1.0821.00
68_L131_M1.0811.00
164_L168_G1.0701.00
111_Q122_N1.0661.00
147_F156_R1.0661.00
2_V36_V1.0611.00
46_L91_L1.0601.00
156_R159_E1.0591.00
149_D152_A1.0551.00
26_V29_K1.0541.00
46_L87_L1.0411.00
26_V31_Q1.0271.00
3_I7_R1.0181.00
71_H132_L1.0091.00
51_A54_E0.9961.00
4_A8_R0.9861.00
7_R11_E0.9831.00
17_L160_T0.9801.00
152_A156_R0.9781.00
3_I34_Y0.9761.00
123_Y126_R0.9741.00
54_E95_L0.9721.00
6_T127_S0.9701.00
147_F150_P0.9641.00
39_A48_D0.9611.00
59_A64_I0.9441.00
24_K29_K0.9421.00
27_H30_G0.9291.00
120_I169_W0.9261.00
57_A100_V0.9231.00
154_P158_I0.9221.00
127_S131_M0.9171.00
45_L74_V0.9171.00
79_L82_N0.9041.00
53_L97_L0.9001.00
3_I36_V0.8981.00
161_L169_W0.8951.00
10_L34_Y0.8931.00
43_E47_E0.8891.00
39_A44_A0.8881.00
167_E170_Q0.8871.00
50_L94_E0.8841.00
82_N89_D0.8811.00
53_L101_L0.8781.00
14_V19_L0.8761.00
86_D89_D0.8721.00
116_E122_N0.8621.00
3_I70_I0.8591.00
25_A29_K0.8551.00
90_A94_E0.8440.99
35_V51_A0.8430.99
61_P142_R0.8420.99
46_L84_F0.8420.99
150_P154_P0.8400.99
81_Y104_A0.8390.99
50_L54_E0.8380.99
161_L164_L0.8270.99
33_R67_T0.8230.99
74_V84_F0.8180.99
5_A8_R0.8140.99
116_E121_E0.8130.99
123_Y165_G0.8130.99
36_V70_I0.8110.99
25_A28_V0.8050.99
90_A93_E0.7880.99
83_D86_D0.7850.99
79_L111_Q0.7820.99
48_D69_L0.7810.99
49_L134_L0.7800.99
49_L69_L0.7760.99
70_I131_M0.7760.99
18_N24_K0.7740.99
15_I24_K0.7710.99
50_L53_L0.7670.99
120_I165_G0.7610.99
77_D80_D0.7440.99
142_R146_A0.7400.99
151_E154_P0.7370.99
104_A110_Y0.7350.99
26_V66_T0.7310.98
164_L169_W0.7300.98
91_L95_L0.7230.98
84_F132_L0.7090.98
103_I132_L0.7070.98
109_D117_P0.7050.98
89_D103_I0.7040.98
151_E155_E0.7000.98
49_L132_L0.6920.98
158_I162_R0.6910.98
47_E50_L0.6890.98
60_D63_E0.6880.98
100_V138_A0.6880.98
106_F161_L0.6870.98
7_R27_H0.6850.98
42_P87_L0.6740.97
85_L132_L0.6740.97
166_L169_W0.6720.97
46_L50_L0.6690.97
49_L88_A0.6650.97
86_D90_A0.6590.97
17_L164_L0.6550.97
44_A47_E0.6540.97
12_R16_G0.6480.97
53_L57_A0.6460.97
10_L135_L0.6370.96
64_I136_R0.6360.96
110_Y125_N0.6360.96
160_T168_G0.6330.96
87_L94_E0.6300.96
36_V129_Y0.6280.96
71_H84_F0.6260.96
121_E161_L0.6260.96
102_Q112_F0.6230.96
82_N86_D0.6160.96
161_L168_G0.6140.96
71_H76_Q0.6140.96
110_Y124_T0.6120.95
143_A146_A0.6100.95
26_V32_I0.6040.95
11_E16_G0.6030.95
56_L134_L0.5970.95
42_P83_D0.5930.95
146_A150_P0.5900.94
138_A141_E0.5900.94
32_I66_T0.5850.94
93_E96_G0.5850.94
26_V30_G0.5820.94
6_T70_I0.5810.94
141_E144_V0.5800.94
13_A16_G0.5770.94
82_N85_L0.5740.94
55_L58_A0.5690.93
97_L165_G0.5670.93
42_P84_F0.5660.93
37_S45_L0.5640.93
8_R11_E0.5640.93
36_V72_P0.5600.93
43_E87_L0.5590.93
66_T139_S0.5580.93
49_L103_I0.5570.93
13_A161_L0.5560.93
35_V55_L0.5560.93
85_L110_Y0.5530.92
45_L84_F0.5520.92
56_L67_T0.5510.92
66_T135_L0.5500.92
35_V69_L0.5490.92
51_A55_L0.5490.92
49_L53_L0.5490.92
120_I162_R0.5450.92
50_L87_L0.5370.91
56_L101_L0.5330.91
11_E28_V0.5310.91
76_Q109_D0.5280.91
58_A63_E0.5280.91
143_A147_F0.5270.90
81_Y85_L0.5260.90
120_I168_G0.5200.90
90_A96_G0.5200.90
61_P65_E0.5200.90
4_A7_R0.5180.90
7_R32_I0.5170.90
42_P74_V0.5150.89
120_I124_T0.5140.89
26_V135_L0.5120.89
43_E90_A0.5120.89
19_L124_T0.5100.89
88_A91_L0.5070.89
31_Q142_R0.5020.88
25_A140_I0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1go9A 1 0.2281 7.2 0.951 Contact Map
2rm9A 1 0.1754 7.1 0.951 Contact Map
3iclA 1 0.5848 6.7 0.952 Contact Map
3hvaA 1 0.5673 6.5 0.952 Contact Map
4n9gC 1 0.0877 6.3 0.953 Contact Map
1k3kA 1 0.2398 5.3 0.954 Contact Map
3mtkA 2 0.5848 4.4 0.956 Contact Map
3kt7A 2 0.4211 3.7 0.958 Contact Map
4i4tA 1 0.924 3.5 0.958 Contact Map
3optA 1 0.5556 3.4 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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