GREMLIN Database
DUF1413 - Domain of unknown function (DUF1413)
PFAM: PF07205 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 69 (67)
Sequences: 725 (569)
Seq/√Len: 69.5
META: 0.806

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_K68_K4.2221.00
32_R36_L4.0601.00
59_K63_N3.5241.00
56_A65_Q2.8561.00
4_I7_I2.1751.00
5_K8_E2.1241.00
14_E29_R2.0681.00
15_E58_E2.0341.00
18_V38_L1.8901.00
43_L47_K1.7891.00
23_K26_E1.6100.99
60_T66_R1.5750.99
33_G39_G1.5700.99
33_G40_R1.3810.98
59_K65_Q1.2790.97
17_L64_Q1.2660.97
6_E23_K1.2610.96
8_E47_K1.2310.96
36_L62_S1.2180.96
6_E25_Y1.2060.95
6_E10_L1.1760.95
15_E68_K1.1730.95
3_A18_V1.1610.94
46_V56_A1.1300.94
19_K28_N1.1270.93
39_G67_Y1.0920.92
35_R64_Q1.0800.92
46_V49_G1.0720.92
16_F42_F1.0390.90
4_I53_G1.0190.89
11_P14_E1.0170.89
22_F26_E0.9970.88
30_I34_D0.9690.87
20_D23_K0.9660.87
46_V53_G0.9250.84
14_E17_L0.9190.84
12_S69_K0.9190.84
37_L41_L0.9140.84
28_N35_R0.9080.83
16_F21_L0.9030.83
19_K36_L0.9010.83
43_L65_Q0.8830.81
22_F42_F0.8750.81
9_N61_S0.8590.80
35_R65_Q0.8520.79
15_E66_R0.8430.78
19_K24_G0.8390.78
37_L40_R0.8350.78
46_V50_K0.7990.75
6_E26_E0.7580.71
18_V42_F0.7580.71
50_K55_K0.7400.69
58_E66_R0.7280.67
6_E9_N0.7220.67
49_G53_G0.7200.67
30_I35_R0.7190.67
7_I10_L0.6990.64
26_E63_N0.6950.64
42_F69_K0.6850.63
53_G68_K0.6850.63
30_I37_L0.6720.61
4_I45_Y0.6700.61
60_T64_Q0.6690.61
19_K44_N0.6650.60
26_E33_G0.6640.60
42_F54_I0.6430.58
5_K47_K0.6320.57
4_I47_K0.6310.57
49_G52_P0.6310.57
40_R44_N0.6280.56
38_L64_Q0.6250.56
15_E29_R0.6190.55
4_I8_E0.6190.55
24_G29_R0.6170.55
6_E69_K0.6140.54
11_P55_K0.6070.54
19_K66_R0.6040.53
30_I41_L0.6000.53
32_R43_L0.5940.52
5_K11_P0.5940.52
30_I38_L0.5900.52
11_P52_P0.5890.51
45_Y48_K0.5880.51
13_G55_K0.5870.51
25_Y29_R0.5860.51
20_D64_Q0.5820.51
21_L24_G0.5740.50
10_L21_L0.5720.49
33_G58_E0.5630.48
12_S50_K0.5420.46
57_I68_K0.5410.46
8_E53_G0.5400.46
5_K52_P0.5250.44
15_E57_I0.5230.44
17_L34_D0.5190.43
31_S58_E0.5150.43
16_F22_F0.5110.42
10_L29_R0.5080.42
3_A7_I0.5040.41
19_K33_G0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rxxA 1 0.4493 5.5 0.872 Contact Map
4rh7A 1 0.9565 5.2 0.874 Contact Map
1vykA 1 0.942 4.7 0.877 Contact Map
3zq4A 3 0.8551 4.7 0.877 Contact Map
1vm6A 4 0.3478 4.2 0.879 Contact Map
2irfG 1 0.5072 4 0.881 Contact Map
3v9fA 1 0.5797 3.7 0.883 Contact Map
1jg7A 1 0.6957 3.3 0.885 Contact Map
3up8A 1 0.4058 3.2 0.887 Contact Map
2dllA 1 0.5797 3.1 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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