GREMLIN Database
SF3b10 - Splicing factor 3B subunit 10 (SF3b10)
PFAM: PF07189 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 78 (78)
Sequences: 546 (331)
Seq/√Len: 37.4
META: 0.559

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_T41_Y3.7421.00
72_Q76_P3.2561.00
30_A33_Q3.1811.00
40_S44_H2.9771.00
58_S61_R2.2840.99
41_Y47_L2.1970.99
38_Y66_L1.9670.98
75_G78_P1.9570.98
48_L63_R1.9480.98
41_Y51_F1.9450.98
57_E65_N1.9020.98
27_F31_T1.8740.98
37_T51_F1.7690.97
55_E65_N1.7640.97
60_G63_R1.7480.97
11_H15_K1.6120.95
49_S59_I1.4780.92
60_G64_F1.4530.91
30_A34_H1.4530.91
38_Y41_Y1.3750.88
17_V32_N1.3630.88
49_S52_A1.3370.87
13_Q32_N1.3110.86
71_L77_P1.2050.81
67_L72_Q1.1960.80
45_P49_S1.1610.78
2_R6_Q1.1560.78
64_F68_E1.1380.77
8_Q12_L1.1180.76
45_P59_I1.0970.74
6_Q9_L1.0820.73
14_A30_A1.0730.72
46_D49_S1.0480.71
2_R5_I1.0460.70
13_Q19_T1.0330.70
19_T29_W1.0250.69
48_L62_V1.0130.68
25_T28_E0.9990.67
66_L69_K0.9940.67
42_I67_L0.9690.65
62_V65_N0.9650.64
52_A62_V0.9590.64
42_I49_S0.9580.64
38_Y69_K0.9390.62
5_I51_F0.9310.61
33_Q47_L0.9230.61
31_T57_E0.9220.61
48_L69_K0.9180.60
74_C78_P0.8860.58
34_H69_K0.8860.58
51_F66_L0.8650.56
3_Y6_Q0.8620.55
50_Y54_A0.8590.55
26_K68_E0.8550.55
13_Q17_V0.8540.55
46_D66_L0.8390.53
8_Q11_H0.8100.51
4_N7_S0.7850.49
48_L76_P0.7730.48
25_T48_L0.7730.48
15_K21_H0.7720.47
9_L13_Q0.7710.47
24_T39_A0.7680.47
68_E72_Q0.7560.46
27_F47_L0.7360.44
65_N69_K0.7280.44
20_G40_S0.7210.43
14_A57_E0.7100.42
27_F76_P0.7050.42
22_A31_T0.7020.41
62_V66_L0.7000.41
1_D4_N0.6950.41
17_V43_G0.6910.40
41_Y66_L0.6840.40
13_Q29_W0.6790.39
15_K18_G0.6730.39
55_E62_V0.6680.38
10_E13_Q0.6570.38
2_R8_Q0.6540.37
72_Q77_P0.6420.36
27_F68_E0.6380.36
16_Y19_T0.6320.35
35_R40_S0.6290.35
7_S41_Y0.6280.35
15_K56_N0.6260.35
27_F46_D0.6260.35
20_G67_L0.6220.35
35_R43_G0.6170.34
11_H14_A0.6100.34
52_A59_I0.6090.34
20_G32_N0.6050.33
27_F56_N0.6030.33
48_L77_P0.6010.33
9_L12_L0.6000.33
31_T47_L0.5980.33
34_H66_L0.5950.33
29_W68_E0.5880.32
60_G67_L0.5700.31
4_N60_G0.5650.30
18_G29_W0.5610.30
57_E72_Q0.5590.30
29_W64_F0.5540.29
51_F62_V0.5520.29
17_V26_K0.5380.28
53_I59_I0.5370.28
7_S11_H0.5290.28
34_H71_L0.5280.28
8_Q16_Y0.5250.27
1_D6_Q0.5230.27
3_Y33_Q0.5220.27
1_D24_T0.5190.27
48_L65_N0.5180.27
3_Y24_T0.5170.27
16_Y24_T0.5170.27
10_E18_G0.5140.27
59_I64_F0.5080.26
26_K30_A0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jqnA 3 0.8846 12.2 0.924 Contact Map
4s0vA 1 0.9103 7.4 0.931 Contact Map
2i06A 1 0.9872 7.4 0.931 Contact Map
4gfjA 1 0.8974 5.8 0.935 Contact Map
2q88A 1 0.4103 5.2 0.936 Contact Map
3t5tA 2 0.8718 3.5 0.941 Contact Map
2p7nA 2 0.9359 3.4 0.941 Contact Map
3froA 3 0.9103 3.4 0.941 Contact Map
4oqrA 1 0.0385 2.8 0.944 Contact Map
4bxhA 3 0.8462 2.8 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0185 seconds.