GREMLIN Database
DUF1405 - Protein of unknown function (DUF1405)
PFAM: PF07187 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 157 (156)
Sequences: 1194 (829)
Seq/√Len: 66.4
META: 0.58

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_T23_V5.1271.00
39_L46_S3.0561.00
122_V128_F2.8811.00
55_V109_L2.7721.00
56_T116_T2.6601.00
6_Y9_G2.5921.00
59_K120_D2.4301.00
145_A148_F2.4151.00
18_W21_P2.2451.00
35_L49_L2.1891.00
107_W111_V2.1431.00
36_A50_E2.0881.00
35_L39_L2.0781.00
9_G13_A2.0401.00
26_S29_A2.0221.00
121_V126_F1.9241.00
11_Q15_T1.8811.00
145_A149_W1.8781.00
48_L107_W1.8181.00
69_L73_A1.7901.00
121_V125_V1.7891.00
113_A155_L1.7741.00
29_A56_T1.7401.00
105_K108_A1.7381.00
16_P128_F1.6860.99
69_L85_I1.6530.99
52_L112_A1.6490.99
36_A40_L1.6080.99
48_L111_V1.5640.99
26_S53_A1.5500.99
147_T151_S1.5490.99
50_E102_Y1.5410.99
55_V116_T1.5320.99
66_V146_F1.5090.99
58_I96_L1.4910.99
50_E101_F1.4880.99
84_L87_S1.4870.99
17_P21_P1.4830.99
129_H140_L1.4650.98
36_A101_F1.4550.98
65_V85_I1.4490.98
29_A53_A1.4360.98
36_A98_Y1.4360.98
114_A118_L1.3970.98
26_S91_M1.3930.98
122_V126_F1.3680.98
54_F95_A1.3670.98
22_F122_V1.3450.97
57_L94_E1.3310.97
19_F122_V1.3120.97
34_T38_L1.3020.97
80_Q83_M1.3010.97
68_L72_A1.2780.96
62_L92_A1.2720.96
22_F118_L1.2440.96
10_P13_A1.2270.95
56_T115_W1.2180.95
141_A148_F1.2140.95
36_A39_L1.1970.95
25_D130_P1.1840.94
38_L42_L1.1830.94
39_L49_L1.1640.94
117_L152_I1.1610.94
54_F96_L1.1570.94
144_G148_F1.1480.93
153_L156_A1.1450.93
83_M87_S1.1380.93
62_L89_L1.1270.93
141_A145_A1.1100.92
58_I62_L1.1080.92
125_V130_P1.1040.92
68_L81_G1.0950.92
114_A117_L1.0860.91
65_V89_L1.0830.91
50_E98_Y1.0800.91
82_W85_I1.0750.91
26_S30_S1.0750.91
30_S34_T1.0590.90
129_H132_L1.0450.90
126_F142_A1.0340.89
63_W124_Y1.0190.88
110_A156_A1.0100.88
17_P20_W0.9880.87
117_L120_D0.9760.86
79_T82_W0.9740.86
90_G93_V0.9730.86
1_T30_S0.9610.85
118_L131_W0.9490.84
9_G20_W0.9420.84
128_F133_Y0.9360.84
64_A68_L0.9220.83
51_A112_A0.9080.82
137_D140_L0.9070.82
123_D130_P0.9040.81
45_N50_E0.9010.81
4_G8_Y0.8960.81
14_E132_L0.8930.81
135_P138_D0.8840.80
16_P20_W0.8650.78
137_D141_A0.8610.78
108_A112_A0.8590.78
33_F37_L0.8590.78
141_A144_G0.8580.78
72_A81_G0.8560.78
53_A57_L0.8510.77
136_L139_Y0.8510.77
79_T86_V0.8460.77
3_Y7_W0.8430.77
64_A67_M0.8410.77
34_T57_L0.8400.76
116_T120_D0.8380.76
74_Q139_Y0.8300.76
5_Y28_T0.8240.75
96_L134_S0.8220.75
144_G150_L0.8080.74
55_V155_L0.8040.73
11_Q23_V0.7990.73
53_A94_E0.7990.73
6_Y10_P0.7910.72
74_Q138_D0.7880.72
58_I92_A0.7860.72
72_A82_W0.7810.71
98_Y101_F0.7780.71
149_W152_I0.7760.71
3_Y84_L0.7720.70
129_H137_D0.7690.70
64_A133_Y0.7680.70
16_P37_L0.7640.69
82_W86_V0.7620.69
71_F76_G0.7590.69
78_L82_W0.7580.69
7_W68_L0.7510.68
78_L81_G0.7470.68
57_L91_M0.7460.68
73_A81_G0.7430.67
118_L145_A0.7410.67
96_L99_A0.7320.66
64_A116_T0.7280.66
3_Y98_Y0.7220.65
94_E156_A0.7180.65
47_P104_F0.7170.64
1_T31_L0.7120.64
21_P118_L0.7080.63
142_A146_F0.7080.63
117_L151_S0.7050.63
12_L60_Y0.6910.62
143_I146_F0.6880.61
29_A119_N0.6870.61
89_L93_V0.6870.61
121_V148_F0.6860.61
72_A95_A0.6840.61
9_G14_E0.6730.60
68_L71_F0.6710.59
76_G80_Q0.6580.58
107_W110_A0.6580.58
47_P50_E0.6530.57
36_A102_Y0.6460.56
86_V90_G0.6450.56
5_Y24_P0.6450.56
42_L96_L0.6420.56
71_F85_I0.6410.56
14_E77_S0.6410.56
140_L143_I0.6390.56
12_L20_W0.6380.56
35_L45_N0.6340.55
32_F87_S0.6310.55
71_F133_Y0.6300.55
152_I156_A0.6290.54
86_V115_W0.6290.54
25_D32_F0.6290.54
13_A16_P0.6270.54
53_A87_S0.6240.54
58_I102_Y0.6220.54
30_S87_S0.6200.53
37_L90_G0.6200.53
17_P106_V0.6190.53
76_G79_T0.6170.53
18_W38_L0.6150.53
24_P84_L0.6130.53
127_G141_A0.6120.52
135_P143_I0.6110.52
151_S155_L0.6090.52
25_D123_D0.6050.52
112_A155_L0.5940.50
2_I6_Y0.5870.50
77_S80_Q0.5850.49
21_P26_S0.5840.49
20_W128_F0.5810.49
72_A78_L0.5760.48
106_V109_L0.5750.48
112_A130_P0.5680.47
118_L121_V0.5680.47
30_S33_F0.5660.47
3_Y6_Y0.5580.46
86_V89_L0.5570.46
141_A156_A0.5560.46
57_L68_L0.5540.46
150_L153_L0.5540.46
135_P140_L0.5520.45
42_L45_N0.5510.45
143_I149_W0.5480.45
27_P84_L0.5480.45
72_A90_G0.5450.45
49_L53_A0.5440.44
60_Y116_T0.5390.44
96_L153_L0.5380.44
7_W30_S0.5370.44
37_L67_M0.5360.44
3_Y11_Q0.5350.43
11_Q84_L0.5350.43
127_G140_L0.5350.43
141_A147_T0.5320.43
118_L149_W0.5320.43
66_V70_L0.5300.43
5_Y64_A0.5300.43
29_A116_T0.5290.43
21_P77_S0.5270.43
58_I154_S0.5220.42
29_A57_L0.5220.42
52_L95_A0.5190.42
60_Y65_V0.5170.41
53_A89_L0.5160.41
89_L116_T0.5140.41
135_P139_Y0.5130.41
75_G79_T0.5130.41
20_W134_S0.5120.41
58_I153_L0.5110.41
113_A117_L0.5100.41
44_R106_V0.5070.40
82_W147_T0.5050.40
151_S154_S0.5050.40
24_P122_V0.5020.40
14_E17_P0.5000.39
55_V94_E0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tw5A 1 0.3312 1.2 0.966 Contact Map
4hkrA 3 0.2548 1 0.968 Contact Map
2mfrA 1 0.3439 1 0.968 Contact Map
2hfrA 1 0.172 1 0.968 Contact Map
2jp3A 1 0.2293 0.9 0.969 Contact Map
4m64A 1 0.3567 0.9 0.969 Contact Map
3wu2T 1 0.1338 0.8 0.97 Contact Map
2l6wA 2 0.1592 0.8 0.97 Contact Map
2jwaA 2 0.1529 0.7 0.971 Contact Map
2k1aA 1 0.242 0.7 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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