GREMLIN Database
DUF1403 - Protein of unknown function (DUF1403)
PFAM: PF07183 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 311 (304)
Sequences: 650 (440)
Seq/√Len: 25.2
META: 0.635

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_A19_A5.6291.00
15_A20_E4.8861.00
15_A18_R4.8561.00
16_R19_A4.3881.00
15_A21_E4.3291.00
85_R88_D3.9071.00
42_V52_W3.7331.00
159_V164_P3.6901.00
89_D95_R3.3141.00
16_R20_E3.2611.00
17_A20_E3.0941.00
149_P153_A3.0231.00
275_T278_P2.9661.00
277_L280_S2.7310.99
16_R21_E2.7190.99
287_L297_V2.6850.99
18_R21_E2.6730.99
17_A21_E2.6160.99
39_D43_R2.5790.99
279_L287_L2.1850.97
81_V84_T2.1600.97
62_A74_E2.1400.97
65_V68_A2.0960.96
299_E302_G2.0600.96
153_A164_P2.0430.96
182_L240_R1.9650.95
264_L288_F1.9630.94
161_A164_P1.9510.94
246_L260_A1.8870.93
307_R310_G1.8720.93
15_A23_T1.8520.93
59_R230_E1.8400.92
11_L15_A1.8340.92
157_A161_A1.8330.92
234_L238_L1.8280.92
301_T308_L1.8040.92
195_L200_L1.7930.91
299_E303_R1.7790.91
73_D76_A1.7590.90
135_A138_L1.7520.90
160_A164_P1.7520.90
89_D280_S1.7470.90
146_R149_P1.7310.90
262_E266_S1.7190.89
134_L138_L1.7040.89
145_A151_A1.6190.86
188_V231_A1.6100.86
225_A229_A1.6060.86
303_R307_R1.5900.85
130_A140_A1.5860.85
147_P151_A1.5740.85
276_G279_L1.5720.85
282_R285_R1.5410.83
225_A228_A1.5400.83
303_R306_F1.5390.83
132_A138_L1.5090.82
282_R292_V1.5070.82
274_A277_L1.5030.82
275_T280_S1.5030.82
269_A300_L1.4430.79
145_A149_P1.4380.79
159_V162_L1.4300.78
7_T27_A1.4260.78
65_V96_L1.4130.78
72_E93_A1.3900.76
132_A135_A1.3820.76
151_A157_A1.3780.76
167_E235_A1.3700.75
20_E23_T1.3700.75
171_L216_L1.3690.75
303_R310_G1.3680.75
281_D289_D1.3630.75
300_L303_R1.3550.74
192_A195_L1.3540.74
274_A280_S1.3510.74
65_V77_L1.3380.74
42_V270_V1.3370.73
82_H308_L1.3340.73
41_V45_E1.3330.73
305_T309_Y1.3270.73
155_A158_A1.3220.73
153_A158_A1.3170.72
303_R309_Y1.3160.72
185_P246_L1.3160.72
37_H40_L1.3110.72
52_W149_P1.3060.72
73_D198_A1.3050.72
15_A25_E1.2900.71
139_D143_L1.2830.70
272_P276_G1.2790.70
285_R294_L1.2740.70
133_D138_L1.2700.70
158_A161_A1.2680.69
179_A241_R1.2660.69
29_F35_L1.2470.68
52_W231_A1.2200.66
237_D241_R1.2120.66
147_P152_A1.1950.65
158_A164_P1.1910.64
286_R290_R1.1900.64
36_A40_L1.1690.63
244_R280_S1.1690.63
81_V98_L1.1650.63
250_P254_A1.1590.62
306_F310_G1.1550.62
274_A283_A1.1540.62
291_L299_E1.1470.61
33_A36_A1.1310.60
154_A191_L1.1290.60
19_A23_T1.1270.60
282_R295_G1.1260.60
213_G217_R1.1180.59
167_E170_A1.1130.59
272_P282_R1.1090.59
283_A289_D1.1060.59
53_R223_A1.1030.58
86_P101_R1.1020.58
39_D49_A1.0950.58
57_A61_A1.0830.57
275_T279_L1.0800.57
179_A249_A1.0790.57
13_A63_A1.0780.57
144_S149_P1.0690.56
193_A227_A1.0690.56
138_L144_S1.0680.56
230_E233_R1.0600.55
224_L233_R1.0560.55
27_A174_A1.0490.54
8_L16_R1.0480.54
59_R74_E1.0470.54
68_A96_L1.0430.54
278_P287_L1.0420.54
123_G127_D1.0410.54
42_V48_P1.0380.54
78_R268_D1.0350.53
149_P152_A1.0310.53
48_P260_A1.0240.53
8_L11_L1.0200.52
139_D142_A1.0170.52
97_L229_A1.0130.52
153_A159_V1.0130.52
97_L177_V1.0100.52
148_A153_A1.0100.52
49_A248_V1.0080.52
246_L262_E1.0050.51
48_P264_L1.0040.51
297_V301_T1.0030.51
137_E147_P0.9950.51
291_L303_R0.9930.50
197_R270_V0.9910.50
10_R27_A0.9860.50
274_A279_L0.9820.50
77_L106_R0.9780.49
277_L287_L0.9770.49
18_R23_T0.9710.49
119_A127_D0.9700.49
119_A126_W0.9660.48
252_L257_A0.9660.48
37_H42_V0.9650.48
299_E307_R0.9640.48
80_A94_G0.9610.48
248_V252_L0.9610.48
84_T194_G0.9580.48
84_T97_L0.9560.48
67_L96_L0.9550.48
42_V197_R0.9470.47
81_V97_L0.9370.46
77_L97_L0.9350.46
304_D309_Y0.9350.46
48_P51_L0.9310.46
77_L274_A0.9290.46
13_A23_T0.9170.45
254_A283_A0.9160.45
84_T89_D0.9150.45
103_L172_W0.9100.44
299_E306_F0.9020.44
136_D139_D0.9020.44
251_K255_K0.9000.44
65_V76_A0.9000.44
306_F309_Y0.8980.44
298_R303_R0.8930.43
175_D245_L0.8910.43
138_L151_A0.8850.43
148_A154_A0.8810.42
94_G256_G0.8810.42
105_E115_L0.8700.42
116_A119_A0.8700.42
143_L151_A0.8670.41
292_V301_T0.8670.41
178_L244_R0.8670.41
290_R299_E0.8630.41
302_G307_R0.8620.41
200_L209_P0.8570.41
17_A23_T0.8570.41
256_G279_L0.8550.40
33_A285_R0.8520.40
83_L166_A0.8460.40
26_D98_L0.8460.40
279_L301_T0.8380.39
262_E275_T0.8370.39
106_R296_A0.8360.39
233_R270_V0.8360.39
216_L221_H0.8340.39
140_A155_A0.8340.39
16_R25_E0.8310.39
71_R167_E0.8270.39
86_P258_G0.8250.38
302_G306_F0.8250.38
144_S147_P0.8210.38
48_P288_F0.8180.38
97_L198_A0.8180.38
200_L220_C0.8160.38
132_A140_A0.8140.38
263_L272_P0.8140.38
227_A289_D0.8100.37
77_L107_P0.8080.37
55_R268_D0.8050.37
235_A256_G0.8050.37
155_A162_L0.8030.37
133_D137_E0.8030.37
144_S153_A0.8020.37
254_A260_A0.7970.36
33_A40_L0.7960.36
273_S279_L0.7950.36
16_R224_L0.7870.36
176_A217_R0.7870.36
13_A242_A0.7850.36
93_A191_L0.7820.35
299_E310_G0.7800.35
270_V274_A0.7800.35
213_G267_E0.7790.35
131_L134_L0.7790.35
233_R283_A0.7780.35
52_W278_P0.7770.35
19_A24_E0.7760.35
154_A190_L0.7750.35
274_A278_P0.7750.35
11_L44_R0.7740.35
271_A283_A0.7740.35
158_A162_L0.7730.35
273_S278_P0.7720.35
116_A239_A0.7680.35
108_V180_Q0.7670.34
299_E309_Y0.7640.34
115_L118_L0.7640.34
53_R77_L0.7630.34
183_G229_A0.7600.34
244_R258_G0.7590.34
293_E301_T0.7590.34
208_R213_G0.7570.34
75_A259_A0.7520.34
116_A243_A0.7510.33
41_V232_L0.7510.33
83_L279_L0.7430.33
39_D45_E0.7430.33
63_A192_A0.7410.33
82_H258_G0.7400.33
205_G247_A0.7390.33
118_L134_L0.7340.32
85_R89_D0.7330.32
290_R303_R0.7330.32
289_D295_G0.7280.32
97_L239_A0.7280.32
286_R307_R0.7240.32
132_A248_V0.7240.32
219_A284_A0.7220.32
171_L243_A0.7210.32
136_D169_L0.7160.31
110_V113_K0.7160.31
223_A236_A0.7150.31
195_L256_G0.7130.31
286_R291_L0.7100.31
66_R280_S0.7080.31
80_A167_E0.7070.31
175_D225_A0.7060.31
47_V239_A0.7040.30
16_R27_A0.7020.30
71_R98_L0.7000.30
37_H99_A0.6980.30
38_L91_G0.6970.30
216_L224_L0.6950.30
172_W287_L0.6950.30
54_Q267_E0.6940.30
145_A153_A0.6920.30
54_Q178_L0.6920.30
231_A245_L0.6910.30
116_A131_L0.6900.30
56_L234_L0.6900.30
6_D13_A0.6870.29
11_L26_D0.6860.29
68_A110_V0.6810.29
302_G309_Y0.6790.29
145_A150_P0.6770.29
19_A25_E0.6750.29
170_A284_A0.6740.29
280_S311_L0.6720.29
175_D239_A0.6710.28
302_G310_G0.6700.28
276_G297_V0.6700.28
215_D311_L0.6700.28
80_A256_G0.6700.28
30_L44_R0.6670.28
291_L302_G0.6650.28
171_L220_C0.6640.28
215_D255_K0.6600.28
88_D239_A0.6600.28
216_L282_R0.6590.28
229_A233_R0.6590.28
235_A283_A0.6590.28
97_L193_A0.6580.28
27_A80_A0.6570.28
66_R177_V0.6560.28
151_A177_V0.6540.27
63_A201_R0.6540.27
252_L255_K0.6510.27
250_P253_R0.6450.27
100_W176_A0.6440.27
107_P115_L0.6430.27
250_P288_F0.6430.27
291_L295_G0.6430.27
145_A160_A0.6420.27
40_L116_A0.6370.27
231_A287_L0.6370.27
65_V93_A0.6340.26
32_G35_L0.6330.26
182_L187_P0.6320.26
114_R173_L0.6300.26
65_V101_R0.6250.26
231_A248_V0.6250.26
54_Q82_H0.6240.26
178_L237_D0.6230.26
15_A191_L0.6220.26
145_A271_A0.6220.26
91_G103_L0.6210.26
99_A233_R0.6200.26
228_A243_A0.6190.26
101_R267_E0.6180.25
65_V256_G0.6180.25
51_L100_W0.6150.25
201_R217_R0.6120.25
121_L124_L0.6120.25
248_V269_A0.6120.25
7_T10_R0.6110.25
30_L247_A0.6110.25
17_A25_E0.6100.25
106_R180_Q0.6100.25
273_S297_V0.6090.25
303_R308_L0.6080.25
106_R176_A0.6070.25
80_A283_A0.6040.25
98_L176_A0.6020.25
233_R259_A0.5990.24
281_D292_V0.5950.24
27_A93_A0.5950.24
149_P161_A0.5930.24
113_K188_V0.5930.24
153_A160_A0.5920.24
181_A185_P0.5880.24
260_A270_V0.5880.24
16_R24_E0.5870.24
76_A297_V0.5870.24
146_R215_D0.5870.24
120_E124_L0.5850.24
34_A42_V0.5850.24
131_L135_A0.5820.24
88_D164_P0.5810.23
66_R279_L0.5810.23
290_R294_L0.5800.23
46_P279_L0.5800.23
272_P275_T0.5790.23
83_L98_L0.5780.23
60_A68_A0.5770.23
147_P150_P0.5750.23
36_A64_C0.5740.23
290_R310_G0.5730.23
285_R293_E0.5720.23
271_A305_T0.5720.23
237_D240_R0.5710.23
136_D142_A0.5700.23
282_R286_R0.5690.23
109_S176_A0.5690.23
307_R311_L0.5680.23
224_L257_A0.5670.23
294_L309_Y0.5660.23
248_V262_E0.5660.23
76_A283_A0.5650.23
8_L13_A0.5590.22
117_A135_A0.5580.22
144_S151_A0.5580.22
96_L270_V0.5560.22
34_A70_R0.5550.22
256_G260_A0.5540.22
6_D10_R0.5540.22
153_A161_A0.5520.22
152_A156_A0.5510.22
136_D143_L0.5510.22
8_L23_T0.5510.22
190_L238_L0.5510.22
184_W228_A0.5500.22
47_V68_A0.5490.22
121_L126_W0.5490.22
10_R41_V0.5490.22
295_G303_R0.5480.22
137_E141_A0.5480.22
78_R310_G0.5470.22
130_A248_V0.5470.22
101_R193_A0.5430.22
126_W129_D0.5420.21
60_A171_L0.5400.21
181_A188_V0.5390.21
226_R234_L0.5390.21
76_A248_V0.5360.21
124_L130_A0.5360.21
100_W304_D0.5350.21
100_W160_A0.5350.21
273_S293_E0.5340.21
51_L308_L0.5330.21
71_R259_A0.5330.21
34_A38_L0.5300.21
148_A152_A0.5290.21
45_E59_R0.5290.21
166_A248_V0.5290.21
73_D213_G0.5290.21
8_L21_E0.5290.21
54_Q67_L0.5280.21
121_L125_A0.5280.21
131_L232_L0.5280.21
81_V193_A0.5270.21
144_S155_A0.5220.21
183_G186_H0.5220.21
42_V114_R0.5210.20
60_A192_A0.5210.20
182_L226_R0.5200.20
281_D285_R0.5190.20
142_A145_A0.5190.20
117_A187_P0.5170.20
170_A195_L0.5160.20
215_D257_A0.5150.20
270_V276_G0.5150.20
29_F32_G0.5150.20
71_R82_H0.5130.20
252_L292_V0.5130.20
100_W308_L0.5130.20
177_V192_A0.5130.20
67_L167_E0.5110.20
157_A301_T0.5110.20
37_H62_A0.5110.20
75_A145_A0.5090.20
13_A26_D0.5090.20
55_R58_L0.5080.20
172_W264_L0.5070.20
260_A288_F0.5060.20
52_W59_R0.5050.20
98_L106_R0.5040.20
146_R151_A0.5030.20
48_P256_G0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eqxA 2 0.9486 87.1 0.953 Contact Map
4rayA 4 0.2251 35.9 0.967 Contact Map
2o03A 2 0.1929 34.8 0.968 Contact Map
2fu4A 2 0.209 31.2 0.968 Contact Map
3mwmA 2 0.1768 29.8 0.969 Contact Map
2w57A 2 0.209 21.1 0.971 Contact Map
3eyyA 2 0.2154 19.8 0.971 Contact Map
2htjA 1 0.1801 15.1 0.973 Contact Map
4mtdA 2 0.2412 14.7 0.973 Contact Map
1z6rA 3 0.1704 14.5 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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