GREMLIN Database
SseB - SseB protein N-terminal domain
PFAM: PF07179 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 118 (114)
Sequences: 7669 (5692)
Seq/√Len: 533.1
META: 0.772

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_R83_A2.8671.00
54_G58_R2.7921.00
53_E59_R2.6671.00
13_D16_A2.5991.00
60_A98_G2.3771.00
85_P88_A2.3151.00
24_L29_L2.1641.00
29_L63_V2.1321.00
63_V99_L1.9491.00
66_S102_N1.9431.00
66_S69_R1.8681.00
2_E102_N1.7631.00
3_A7_A1.7461.00
58_R97_A1.7391.00
34_V48_A1.7301.00
41_V44_G1.6971.00
19_A22_R1.6621.00
4_A23_A1.6271.00
2_E66_S1.6131.00
109_F115_E1.6081.00
69_R106_P1.5911.00
23_A26_D1.5841.00
100_V103_P1.5341.00
114_E117_A1.5111.00
16_A19_A1.4941.00
88_A91_A1.4891.00
2_E69_R1.4601.00
51_T59_R1.4361.00
6_A10_A1.4181.00
70_L81_P1.4071.00
7_A16_A1.3871.00
68_E71_A1.3661.00
6_A107_V1.3521.00
86_G89_L1.3181.00
63_V89_L1.3131.00
3_A6_A1.2981.00
24_L111_L1.2901.00
20_F109_F1.2561.00
58_R98_G1.2481.00
62_P103_P1.2431.00
112_P115_E1.2321.00
18_P22_R1.2301.00
41_V45_S1.2291.00
64_F73_W1.2261.00
67_E81_P1.2251.00
2_E6_A1.1861.00
94_E117_A1.1831.00
5_L9_A1.1681.00
28_R85_P1.1631.00
29_L101_L1.1551.00
14_P17_R1.1511.00
87_A91_A1.1441.00
19_A23_A1.1191.00
113_P117_A1.0961.00
23_A27_A1.0851.00
42_D45_S1.0831.00
105_G108_G1.0381.00
63_V101_L1.0341.00
54_G110_V1.0281.00
5_L8_A1.0211.00
84_L88_A1.0201.00
50_V53_E1.0101.00
89_L93_L1.0081.00
26_D87_A0.9911.00
69_R105_G0.9871.00
8_A12_P0.9711.00
17_R115_E0.9561.00
15_E18_P0.9551.00
29_L86_G0.9481.00
86_G93_L0.9401.00
22_R26_D0.9331.00
31_V49_L0.9311.00
14_P18_P0.9311.00
8_A20_F0.9311.00
101_L111_L0.9301.00
32_P70_L0.9221.00
88_A92_L0.9121.00
96_A113_P0.9091.00
34_V50_V0.9081.00
2_E5_L0.9061.00
54_G60_A0.8971.00
52_L62_P0.8951.00
109_F112_P0.8911.00
47_L50_V0.8881.00
93_L99_L0.8821.00
2_E8_A0.8711.00
83_A86_G0.8661.00
33_V80_V0.8591.00
7_A19_A0.8461.00
76_G79_P0.8381.00
67_E83_A0.8311.00
61_L96_A0.8241.00
67_E70_L0.8141.00
30_L81_P0.8051.00
30_L67_E0.8001.00
5_L20_F0.7961.00
8_A17_R0.7881.00
111_L115_E0.7671.00
12_P17_R0.7651.00
82_V85_P0.7611.00
7_A10_A0.7581.00
100_V108_G0.7481.00
60_A100_V0.7481.00
75_A79_P0.7461.00
33_V82_V0.7461.00
52_L103_P0.7451.00
17_R20_F0.7451.00
67_E71_A0.7321.00
107_V110_V0.7291.00
104_G108_G0.7211.00
72_A76_G0.7211.00
102_N107_V0.7201.00
86_G90_A0.7171.00
71_A74_D0.7071.00
89_L92_L0.7051.00
24_L86_G0.7041.00
64_F74_D0.7021.00
44_G47_L0.6971.00
75_A78_R0.6961.00
63_V111_L0.6881.00
20_F101_L0.6791.00
67_E72_A0.6701.00
33_V70_L0.6631.00
37_A43_K0.6561.00
69_R104_G0.6531.00
21_L25_L0.6521.00
12_P16_A0.6511.00
81_P84_L0.6491.00
65_T101_L0.6391.00
22_R25_L0.6371.00
101_L109_F0.6301.00
25_L90_A0.6241.00
30_L80_V0.6201.00
53_E57_G0.6161.00
4_A19_A0.6151.00
98_G113_P0.6101.00
69_R73_W0.6041.00
14_P19_A0.6031.00
71_A75_A0.5810.99
6_A9_A0.5780.99
95_G117_A0.5740.99
74_D77_A0.5730.99
9_A14_P0.5730.99
28_R32_P0.5680.99
10_A14_P0.5680.99
24_L90_A0.5550.99
98_G117_A0.5540.99
17_R21_L0.5530.99
91_A94_E0.5480.99
59_R97_A0.5420.99
90_A99_L0.5390.99
37_A42_D0.5380.99
21_L109_F0.5360.99
69_R102_N0.5310.99
48_A51_T0.5310.99
37_A45_S0.5290.99
9_A12_P0.5290.99
103_P108_G0.5290.99
3_A8_A0.5260.99
72_A75_A0.5210.99
73_W76_G0.5200.99
40_E43_K0.5200.99
13_D17_R0.5200.99
29_L89_L0.5150.99
98_G109_F0.5140.99
4_A7_A0.5120.99
21_L115_E0.5120.99
51_T96_A0.5120.99
50_V79_P0.5100.99
80_V83_A0.5100.99
31_V84_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev1A 2 0.9492 24.7 0.863 Contact Map
3ihjA 2 0.9068 5.8 0.898 Contact Map
1pq4A 1 0.3475 5.6 0.898 Contact Map
4cl2A 1 0.339 5.1 0.9 Contact Map
1fg7A 2 0.8305 4.9 0.901 Contact Map
3zk9A 1 0.339 4.4 0.903 Contact Map
4mozA 5 0.8051 4.4 0.903 Contact Map
4oxrA 2 0.339 4.3 0.903 Contact Map
2jttC 1 0.2373 4 0.904 Contact Map
4lzpB 2 0.7881 3.9 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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