GREMLIN Database
DUF1400 - Alpha/beta hydrolase of unknown function (DUF1400)
PFAM: PF07176 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 127 (127)
Sequences: 1882 (1317)
Seq/√Len: 116.8
META: 0.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_E117_R6.3911.00
20_D31_S3.3901.00
38_L46_R3.3661.00
98_A102_L3.0701.00
103_A118_A2.9501.00
23_T27_T2.9051.00
56_P109_G2.8181.00
6_V123_T2.6421.00
106_D118_A2.3211.00
22_E26_E2.1801.00
110_L114_N2.1191.00
106_D114_N2.0601.00
65_S101_I2.0441.00
78_T93_F1.9811.00
24_F50_R1.9531.00
42_T45_Q1.9161.00
8_R13_E1.8671.00
81_G91_N1.7631.00
86_T95_A1.7081.00
17_S20_D1.6581.00
85_H127_D1.6471.00
103_A110_L1.6361.00
25_A54_N1.6211.00
23_T31_S1.6211.00
69_Y101_I1.6131.00
99_A115_F1.5771.00
20_D33_E1.5041.00
43_P46_R1.4601.00
45_Q48_E1.4481.00
30_I38_L1.4311.00
62_V66_Q1.3561.00
97_R101_I1.3381.00
18_V116_L1.3251.00
5_I116_L1.3021.00
23_T29_E1.3011.00
16_I30_I1.2931.00
95_A119_Y1.2690.99
18_V124_I1.2540.99
63_L66_Q1.2430.99
18_V22_E1.2240.99
25_A113_L1.1980.99
4_R123_T1.1680.99
86_T119_Y1.1600.99
19_A22_E1.1250.99
72_I76_L1.1230.99
100_L115_F1.1230.99
81_G90_R1.1050.98
16_I36_F1.0780.98
65_S69_Y1.0770.98
27_T30_I1.0760.98
54_N113_L1.0700.98
65_S72_I1.0690.98
72_I75_V1.0340.98
22_E116_L1.0320.98
5_I8_R1.0310.98
24_F40_L0.9750.97
59_V64_V0.9710.97
102_L105_A0.9690.97
51_K58_E0.9610.96
114_N118_A0.9600.96
109_G114_N0.9520.96
81_G92_G0.9430.96
56_P111_T0.9420.96
69_Y94_Q0.9350.96
34_L46_R0.9350.96
103_A114_N0.9300.96
16_I67_L0.9260.96
24_F46_R0.9180.95
41_L45_Q0.9100.95
45_Q76_L0.9090.95
5_I78_T0.9050.95
98_A101_I0.9040.95
102_L106_D0.8980.95
17_S31_S0.8920.95
84_I124_I0.8900.94
80_L116_L0.8890.94
98_A121_T0.8880.94
72_I91_N0.8860.94
81_G85_H0.8760.94
19_A23_T0.8760.94
25_A50_R0.8600.93
6_V127_D0.8590.93
87_P122_E0.8420.93
77_L96_L0.8330.92
68_L77_L0.8310.92
21_L100_L0.8240.92
24_F30_I0.8210.92
104_A110_L0.8200.92
66_Q101_I0.8180.92
31_S34_L0.8140.91
70_S76_L0.8120.91
55_K111_T0.8110.91
89_G125_R0.8080.91
80_L87_P0.8070.91
25_A28_G0.8070.91
60_D89_G0.7950.90
67_L72_I0.7860.90
27_T31_S0.7860.90
71_P75_V0.7730.89
64_V104_A0.7640.89
7_L36_F0.7540.88
1_A8_R0.7530.88
2_A84_I0.7500.88
1_A13_E0.7480.87
22_E25_A0.7480.87
95_A98_A0.7450.87
108_G123_T0.7260.86
6_V13_E0.7250.86
66_Q125_R0.7150.85
62_V98_A0.7060.84
113_L117_R0.7040.84
56_P106_D0.7030.84
66_Q69_Y0.6950.83
110_L115_F0.6940.83
30_I37_Y0.6910.83
52_L57_V0.6900.83
92_G105_A0.6880.83
76_L90_R0.6880.83
54_N118_A0.6850.82
108_G114_N0.6830.82
13_E125_R0.6800.82
47_E123_T0.6780.82
103_A107_P0.6770.82
48_E122_E0.6760.82
92_G119_Y0.6730.81
64_V67_L0.6690.81
26_E43_P0.6600.80
16_I46_R0.6560.80
32_G35_A0.6560.80
32_G36_F0.6520.79
52_L112_L0.6500.79
20_D37_Y0.6490.79
36_F39_K0.6490.79
26_E109_G0.6420.78
18_V115_F0.6410.78
86_T125_R0.6330.77
75_V78_T0.6200.76
31_S112_L0.6180.76
30_I46_R0.6140.75
38_L49_L0.6110.75
9_Y119_Y0.6090.75
24_F57_V0.6020.74
74_E106_D0.6010.74
40_L119_Y0.6000.73
46_R57_V0.5990.73
101_I104_A0.5990.73
80_L83_I0.5970.73
65_S94_Q0.5960.73
4_R17_S0.5930.73
32_G40_L0.5890.72
7_L14_R0.5850.72
79_R124_I0.5800.71
35_A39_K0.5720.70
65_S97_R0.5710.70
5_I11_P0.5700.70
4_R15_S0.5690.69
33_E37_Y0.5670.69
69_Y97_R0.5630.69
71_P115_F0.5610.68
85_H90_R0.5530.67
54_N57_V0.5520.67
81_G93_F0.5480.67
7_L48_E0.5440.66
103_A109_G0.5430.66
34_L38_L0.5420.66
58_E61_P0.5380.65
61_P64_V0.5360.65
76_L87_P0.5350.65
5_I17_S0.5350.65
113_L116_L0.5340.65
32_G64_V0.5340.65
48_E108_G0.5280.64
44_Q111_T0.5270.64
86_T90_R0.5250.63
94_Q98_A0.5230.63
6_V112_L0.5230.63
115_F119_Y0.5210.63
88_S123_T0.5210.63
34_L49_L0.5140.62
79_R83_I0.5130.62
10_G14_R0.5130.62
48_E83_I0.5100.61
16_I85_H0.5090.61
9_Y112_L0.5080.61
33_E36_F0.5080.61
58_E63_L0.5030.60
19_A76_L0.5020.60
28_G50_R0.5010.60
59_V114_N0.5010.60
49_L91_N0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wlrB 1 0.7402 16.2 0.91 Contact Map
1f20A 1 0.8976 13.7 0.913 Contact Map
1tllA 2 0.8898 11.9 0.915 Contact Map
2lnvA 1 0.2756 11.2 0.916 Contact Map
4e1rA 2 0.3228 9.9 0.918 Contact Map
4e1pA 2 0.3228 7.4 0.922 Contact Map
3qfsA 1 0.8268 6.2 0.925 Contact Map
4uelC 1 0.7323 6.1 0.926 Contact Map
3mf7A 3 0.2362 5.5 0.927 Contact Map
2va8A 1 0.6535 5.2 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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