GREMLIN Database
GRP - Glycine rich protein family
PFAM: PF07172 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 95 (92)
Sequences: 559 (505)
Seq/√Len: 52.6
META: 0.274

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_G65_G2.4821.00
6_L11_L2.2091.00
89_G92_G2.2081.00
15_A20_S2.1801.00
31_T36_S2.0611.00
73_G81_G2.0401.00
56_Y91_Y1.9611.00
2_A15_A1.8850.99
41_Q44_K1.8780.99
59_G73_G1.8160.99
84_G87_Y1.8100.99
85_G89_G1.7650.99
57_G70_G1.7440.99
69_Y76_Y1.6620.98
81_G86_G1.6600.98
66_G73_G1.6530.98
67_G89_G1.6410.98
76_Y83_G1.6080.98
84_G92_G1.6050.98
82_G86_G1.5130.97
8_L15_A1.4660.97
81_G87_Y1.4420.96
83_G91_Y1.4330.96
63_G77_G1.3840.95
85_G92_G1.3810.95
3_S7_L1.3370.94
57_G77_G1.3310.94
30_E33_K1.3110.94
64_G71_G1.2970.93
34_S39_T1.2590.92
45_Y48_G1.2390.92
12_L42_D1.2330.91
81_G84_G1.2240.91
65_G72_G1.2130.91
2_A8_L1.2040.90
70_G77_G1.1900.90
70_G84_G1.1790.90
15_A28_L1.1540.89
69_Y78_G1.1480.88
22_E26_R1.1480.88
10_G41_Q1.1260.87
62_G76_Y1.1210.87
71_G78_G1.0980.86
17_L23_V1.0820.85
11_L23_V1.0680.84
56_Y63_G1.0600.84
70_G75_G1.0480.83
5_A11_L1.0380.83
6_L17_L1.0290.82
21_S27_E1.0250.82
6_L10_G1.0200.81
82_G85_G1.0050.80
18_L24_A1.0000.80
23_V26_R0.9950.80
62_G69_Y0.9910.80
6_L15_A0.9820.79
3_S6_L0.9800.79
54_G61_G0.9760.78
72_G79_G0.9700.78
14_A20_S0.9590.77
56_Y76_Y0.9490.77
38_N42_D0.9410.76
34_S37_E0.9400.76
14_A28_L0.9090.73
38_N45_Y0.9080.73
10_G18_L0.9070.73
29_A41_Q0.8800.71
23_V27_E0.8770.71
78_G84_G0.8760.71
65_G83_G0.8650.70
11_L17_L0.8520.68
16_V27_E0.8450.68
12_L24_A0.8390.67
67_G74_G0.8340.67
46_G49_G0.8320.67
75_G91_Y0.8320.67
11_L21_S0.8220.66
39_T42_D0.8100.64
9_L19_I0.8020.64
56_Y64_G0.7980.63
83_G86_G0.7960.63
69_Y83_G0.7850.62
82_G87_Y0.7760.61
22_E25_A0.7710.61
83_G87_Y0.7690.60
63_G70_G0.7640.60
12_L32_E0.7620.60
25_A28_L0.7570.59
71_G77_G0.7480.58
29_A33_K0.7390.57
56_Y59_G0.7330.57
76_Y87_Y0.7270.56
87_Y90_G0.7180.55
4_K37_E0.7130.55
5_A10_G0.7100.54
4_K86_G0.7070.54
61_G69_Y0.7030.54
58_G64_G0.7010.53
30_E44_K0.6980.53
73_G89_G0.6950.53
8_L26_R0.6900.52
9_L22_E0.6890.52
29_A32_E0.6840.52
57_G64_G0.6770.51
31_T34_S0.6740.51
32_E44_K0.6720.50
8_L14_A0.6710.50
37_E43_A0.6690.50
18_L42_D0.6670.50
18_L59_G0.6650.50
16_V22_E0.6530.48
45_Y51_G0.6120.44
69_Y91_Y0.6060.43
32_E39_T0.6020.43
58_G72_G0.5980.43
1_M4_K0.5800.41
82_G89_G0.5800.41
67_G73_G0.5780.41
78_G85_G0.5780.41
19_I37_E0.5710.40
3_S18_L0.5640.39
29_A36_S0.5590.39
79_G86_G0.5590.39
29_A34_S0.5580.39
10_G20_S0.5560.38
60_G78_G0.5540.38
65_G79_G0.5530.38
47_G50_G0.5430.37
11_L26_R0.5420.37
12_L19_I0.5420.37
35_E39_T0.5380.37
52_G58_G0.5370.37
59_G66_G0.5320.36
70_G92_G0.5160.34
41_Q45_Y0.5040.33
86_G89_G0.5030.33
65_G77_G0.5030.33
2_A6_L0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pk2A 3 0.3895 77.8 0.758 Contact Map
4kblA 2 0 59.9 0.787 Contact Map
1zrtD 1 0.3895 36.3 0.815 Contact Map
3cx5D 2 0.4316 31.2 0.821 Contact Map
4d6uD 1 0.4 31.1 0.821 Contact Map
1pp9D 2 0.4 30.4 0.822 Contact Map
2yiuB 1 0.2947 29.4 0.823 Contact Map
3dl8E 1 0.2316 24.4 0.83 Contact Map
2dckA 1 0.6 24 0.83 Contact Map
4p02B 1 0.3158 20.8 0.835 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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